David Cameron to resign as Prime Minister
The UK has voted to leave the European Union after 43 years in a historic referendum
Leave has won by 52% to 48%
East of England votes to Leave by nearly 57% to 43%
Value of the pound falls to its lowest level since 1985
This wasn't the morning Labour MEP Richard Howitt was hoping to wake up to.
Quote MessageWe have to accept that we live in a democracy and respect the rules of the game. I don't believe, however pro-European I may be, that could ever trump the decision of the people in an elected vote."
Richard Howitt, Labour MEP for the East of England
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This was what Vote Leave's East regional director had to say as the scale of his campaign's victory became apparent.
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Chat show host James Corden, who was brought up in High Wycombe, has tweeted:
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Sam Read
BBC Radio Northampton politics reporter
Sam Read, BBC Radio Northampton political reporter has tweeted:
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Northampton is still to declare.
Andrew Sinclair, BBC East political correspondent has tweeted:
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BBC Politics
It's official - the UK has voted to leave the European Union.
London and Scotland voted strongly to stay in the EU but the remain vote has been undermined by poor results in the north of England.
Voters in Wales and the English shires have backed Brexit in large numbers.
The pound fell to its lowest level against the dollar since 1985 as the markets reacted to the results.
Tom Barton
BBC Look East political reporter
We have long known that the east of England is one of the most Euro-skeptic parts of Great Britain.
In the past few hours, that fact has shown itself to be overwhelmingly true.
Across Essex and right up the east coast, people voted for Brexit. The same is also true further west in places like Northamptonshire, Bedfordshire and Hertfordshire, with a few notable exceptions such Norwich and Cambridge.
As the sun rises over Lowestoft this region - just like the rest of Britain - is changed forever.
Katy Lewis
BBC Local Live
Welcome to the live page for Beds, Herts, Bucks and Northants, where, as a BBC forecast suggests the UK has voted by 52% to 48% to leave the European Union after 43 years in an historic referendum, this is the picture locally.
In Beds, Herts and Bucks, only North Hertfordshire, St Albans, Wycombe and Chiltern voted to remain in the European Union.
Aylesbury Vale, Bedford, Broxbourne, Central Bedfordshire, Dacorum, Hertsmere, Luton, Milton Keynes, South Bucks, Stevenage, Three Rivers, Watford and Welwyn Hatfield voted to leave.
In Northamptonshire, with Northampton still to declare, the rest of the county - Corby, Daventry, East Northants, Kettering, South Northants and Wellingborough - voted to leave.