Really, really bad news for Callum Wilson and Bournemouth. How's your luck? That's three serious knee injuries before the end of September. 

Bournemouth boss Eddie Howe: (On the Wilson injury) "It doesn't look good. He's in a brace, he's on crutches and he's in a lot of pain. It looks like it could be another serious knee injury. He took a whack to the knee, thought he was OK to carry on but then collapsed. It's a huge blow.

"I was disappointed with the first half, we didn't react well to Callum's departure but thought we were dominant with the ball in the second half, and at 1-1 there was only going to be one winner, so it's disappointing to have lost from there. We could have defended that situation better."

Image source, Getty Images

Adam in Edinburgh on text: How poor must the league be if this Manchester United team is top? The European competitions will remind us how far the Premier League has fallen since the 2005-10 period.

Christian in Tunbridge Wells: The bottom three clubs have been fighting relegation for years now. It's time for those three clubs to see what the Championship has to offer them.

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Almost game time in Newcastle - you can follow blow-by-blow updates on that one in this page here, while we bring you the best bits accompanied by manager and player reaction from the rest of the day's games in this page.

Liverpool midfielder Lucas Leiva, speaking to Match of the Day about under-fire Reds boss Brendan Rodgers: "We wanted to win for the manager. We know what has been said about him and think we showed we are a group of players behind him and trying to make everything right. We know the pressure is on him but we wanted to play the way he wants us to play and I think we did that."

In League Two, Leyton Orient earned a point at Northampton thanks to a Dean Cox goal in the seventh minute of injury-time, but it failed to prevent them losing top spot to Portsmouth, who won 2-1 at Bristol Rovers. Wycombe moved second, with a 2-0 victory at Exeter. Newport earned their first league win of the season, 1-0 at Carlisle, who were brought back down to earth after taking Liverpool to penalties in the Capital One Cup in midweek.

The perennially unhappy-looking Jose Mourinho has a wonder down to the end of the tunnel at St James' Park ahead of the day's late game.

He looks seriously cheesed off.

Manchester United manager Louis van Gaal: "It's a nice feeling to be top of the table, it's the first time in my period so I'm happy. It's always difficult when you play against a team who is only defending and counting on the counter-attack. You have to be aware and I have to admit my defence was very good today.

"I was very happy with the goal in extra-time because they punished themselves. They were always wasting time and the referee was not reacting to that.

"A goal is the biggest influence in a game and I changed my approach at half-time because of that. It became another game but they didn't come at us very much."

Image source, Getty Images

Matthew on Twitter: LvG knows what he is doing? For £250m+ he should be top of the league!! 3-0 over this awful Sunderland side is a poor result.

Robert Espie: So much saltiness towards United. More points than any other team right now. Just fact.

So were United good today?

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Leicester boss Claudio Ranieri: "It was difficult at the beginning and difficult at the end. We touched the post twice and that was our best moment.

"Arsenal are dangerous on the counter attack. In the first half was good and open but at 3-1 it was difficult.

"We shoot at goal at lot of times but Petr Cech is Petr Cech. I hope if we could hold at 2-1 we could force it until late in the game but Alexis Sanchez scored early. The second half was then finished. We must begin again now and repeat this start to the season.

"We must show character in the next match."

Image source, Getty Images

Peter Collins on Twitter: The only surprise from Sunderland is that they've actually made it to two points! Can they reclaim their record from Derby?

Dave Mangan: When will Tim Sherwood accept we need to go at teams to compete? Two games defence cost us, and attacking won one and was close again today.

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Sunderland manager Dick Advocaat: "The first half we did well, organisation wise, but the problem was they scored one minute before half-time and one minute after half-time. United were the better side but they didn't create a lot of chances. It's a shame we gave that goal away in the first half because it made things different in the second half."  

La Liga has been rocked with news of an injury to Lionel Messi this afternoon but rivals Real Madrid are now in action and looking to go top of the table.

Can they do it? Find out here.

Image source, Getty Images

Rezaa: Arsenal need a striker, they said. Scoring five goals away from home against the only unbeaten side? Think again....

James Graham: Manchester United were fantastic. Patient and composed, Smalling was brilliant. It may be a different style, but it's the future.

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Aston Villa boss Tim Sherwood: "We can't score two away from home and lose - it happened against Leicester as well. You score twice at Anfield and you expect to leave with something. I've told the boys their goals were avoidable and we have to tighten up - Liverpool did not have to work too hard to get them, and we have to put that right."

On Villa's poor start that has seen them drop into the bottom three: "Our performances have merited better than one win in seven games but I said from the start it would be an uphill struggle. We need to stay in the division and, if we do, we will be stronger next year."

Image source, Getty Images

What a job Jimmy Floyd Hasselbaink is doing...

Burton stretched their lead at the top of League One to three points thanks to a 94th-minute winner from Jerome Binnom-Williams, as they came from behind to win 2-1 at Chesterfield. Walsall were held 1-1 at home to Crewe, and Gillingham went down 2-0 at Barnsley. Sheffield United climbed into the top six with a 3-1 derby victory at home to Doncaster, who had defender Gary Mackenzie sent off. Shrewsbury were the only winners in the bottom 10, beating Blackpool, who stay bottom, 2-0.

Tom in Rugby: There's a funny smell coming from Sunderland. Smells like...capitulation...again.

Matt from Monmouth: It seems to me that any team that needs a pick me up, Villa are there to provide the medicine.

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Even a win would not be enough to lift Newcastle out of the bottom three this evening, while Chelsea can jump from 16th to eighth win three points.