Three of the Premier League clubs playing today are guaranteed not to be in the fifth-round draw. And one of them will be either Crystal Palace or Stoke.

The two top-flight clubs meet at Selhurst Park today, but Palace are unable to call on the services of new striker Emmanuel Adebayor. He's not fit despite having plenty of kickabouts on the streets with his mates...

The Watford players will be cowering in their seats on the team bus...

It was only a matter of time. As sure as day turns into night, Tottenham take the lead at Colchester. Nacer Chadli whips in the opener.

Can Colchester fight back? Hmmm. Find out by following in our dedicated coverage.

Image source, Getty Images

Should Aston Villa have been on our list as potential upsets?

Yes, they might both be the Premier League teams but the gulf between Aston Villa and Manchester City is wider than the Amazon River.

A massive 31 points separate rock-bottom Villa and title-chasing City. But home boss Remi Garde is taking comfort from his side's five-match unbeaten run (including two attempts to get past League Two side Wycombe in the last round.)

"We are in a good moment," said the Frenchman. "We lack a bit of confidence in front of goal, but I'm pleased we're not conceding too many goals. That's important."  

Where are we looking for 'Cupsets' this weekend? (Tick that one off your FA Cup cliches bingo card.)  

MK Dons, according to you lot. Our vote has revealed that 27% think the Championship battlers can cause a scene by beating Chelsea at Stadium:mk tomorrow.

Only 5% - wisely judging by the opening 20 minutes - reckon Colchester can nab a result against Spurs.

• Arsenal v Burnley (11%)
• Carlisle v Everton (12%)
• Colchester v Tottenham (5%)
• Nottingham Forest v Watford (17%)
• MK Dons v Chelsea (27%)
• Portsmouth v Bournemouth (18%)
• West Brom v Peterborough (10%)

Chris Sutton
Former Chelsea & Norwich striker on BBC Radio 5 live

"This is a good start for Tottenham, they're opening Colchester up at will. An early goal makes life easy for them - and they'll not want to leave anything to chance."

Image source, Reuters

Colchester might want to take an injunction out against Tottenham - the travelling team have set up camp on their patch. And they're refusing to clear off.

Nacer Chadli had already hit the home post by the time that Harry Kane almost flicked in at the near post. The home team are hanging on.

Follow all the action here.

Martin Keown
Former Arsenal & Aston Villa defender on Football Focus

"Arsenal will have too much for Burnley. They are starting to move through the gears and the manager has won it what, six times? He has shown the competition a great deal of respect and he won't be taking it lightly I am sure."

Martin Keown
Former Arsenal & Aston Villa defender on Football Focus

"Michael Appleton was Blackburn manager for just 67 days, how can you be a manager under that sort of pressure? He's done an outstanding job at Oxford, they're going from strength to strength. They beat Swansea so convincingly, it was a great story. They are still the underdogs, but I wouldn't want to be playing them today."

Worrying moments as the match is stopped just moments after the restart. Colchester centre-half Alex Wynter clashes heads with team-mate Tom Eastman and is taken off on a stretcher after receiving almost five minutes of treatment.

Image source, Reuters

Here we go then - Saturday's FA Cup action is go, go, go!!

Head over here for the minute-by-minute action from Colchester v Tottenham. 

Louis van Gaal will be kicking back on his sofa, glass of red wine in hand (too early?), safe in the knowledge that his team are already in the fifth-round hat.

And winning the FA Cup could buy time for the Dutchman to succeed at Manchester United, says former England striker Alan Shearer.

Van Gaal, 64, has faced criticism as United have struggled in the Premier League and failed to reach the Champions League knockout stage.

"When Arsenal won the FA Cup it kept them going and gave Arsene Wenger a bit of time," said Shearer.

Image source, Getty Images

Greg Archer, Hook, Hampshire, via text: "Just brought my newborn son (Harry) home from the hospital in time for his first Spurs match - perfect timing for his namesake to score first in a Spurs win!"