Fresh from taking over the reigns from Aitor Karanka, Middlesbrough caretaker boss Steve Agnew makes four changes from their recent FA Cup defeat by Manchester City.

Victor Valdes returns in goal in place of Brad Guzan while the other changes are all in attack with Gaston Ramirez, Stewart Downing and Alvaro Negredo coming in for Adama Traore, Rudy Gestede and Cristhian Stuani.

Middlesbrough XI: Valdes, Barragan, Bernardo, Gibson, Da Silva, de Roon, Clayton, Leadbitter, Downing, Negredo, Ramirez. 

Subs: Guzan, Stuani, Fry, Guedioura, Gestede, Forshaw, Traore.   

Jose Mourinho has made seven changes to his Manchester United team that beat FC Rostov in midweek.

David de Gea, Phil Jones, Ashley Young, Michael Carrick, Marouane Fellaini, Jesse Lingard and Marcus Rashford all return. Henrikh Mkhitaryan is on the bench alongside Luke Shaw.

Man Utd XI:  De Gea, Jones, Smalling, Bailly, Valencia, Fellaini, Carrick, Young, Mata, Lingard, Rashford. 

Subs: Rojo, Martial, Romero, Mkhitaryan, Shaw, Fosu-Mensah, Darmian.

Today's game at the Riverside probably has more importance for the bottom of the table than the top. Boro desperately need a win to start trying to claw their way out of trouble.

Manchester United dropped out of the place they have made their own this season - sixth - yesterday. They can, however, overtake Arsenal and move up to fifth with a win today.

Image source, Reuters

Andy Dunn
Football writer on BBC Radio 5 live's Friday Football Social

Wayne Rooney hasn’t played much and there is a doubt over his fitness, but I think his message, Gareth Southgate, is that he is going to make tough decisions.

If Wayne Rooney isn’t playing for Manchester United then he can’t be playing for England.

Southgate sees Rooney as a 10 and obviously thinks England have enough talent going forward.

Southgate’s idea that he picks the side, then the captain, is a complete change of policy.

He won't take him to the World Cup if he's not playing, I'm convinced of that.

Image source, Getty Images

Happy to play on Sunday, Jose? Not at midday...

The Manchester United boss says the Premier League has no interest in helping English clubs in Europe.

United's game at Middlesbrough today comes 62 hours after the end of their Europa League last-16 victory over FC Rostov.

Mourinho says United will "probably lose" and it would be "common sense" for the game to start at 17:00.

"They simply don't care," added the Portuguese of the Premier League, who offered no comment on the situation.

Marcus Rashford starts for Manchester United , Henrikh Mkhitaryan doesn't. Anthony Martial is on the bench along with Luke Shaw. No sign of Wayne Rooney.

Stewart Downing is back in the Boro side. He fell out with Aitor Karanka, shortly before the Spaniard was sacked. 

Image source, PA

Jay: If he is ready to clear out deadwood and buy world class (even if overpriced) players, Wenger should stay.

Shaun Beasley: Can't blame Wenger for gutless players and no appetite to turn up when they are supposedly world class players, players lack respect.

Idle Creep: Arsene's off. If he's staying there's no reason not to say, he's keeping it quiet to minimise the already high media attention.

Image source, PA

BBC Radio 5 live

BBC Radio 5 live is the place to be today to keep up with all of this afternoon's football.

Jonathan Overend is on air from 12:00 GMT with build-up and updates from Middlesbrough v Manchester United before two live commentaries.

First, from 14:15, Ali Bruce-Ball and Martin Keown will take you through Tottenham against Southampton before attention turns to the Etihad Stadium for Liverpool's trip to Manchester City at 16:30 GMT.

That one will be brought to you by Alan Green and Robbie Savage. You can listen to all of that at the top of this page.

Team news for the day's first fixture will be with us in about 15 minutes time. Here is what we know so far...

Middlesbrough's caretaker boss Steve Agnew may have Bernardo Espinosa and Rudy Gestede available after injuries.

Adlene Guedioura returns after being cup-tied, but Daniel Ayala, Calum Chambers and George Friend are out.

Paul Pogba misses out for Manchester United because of a hamstring strain, while Daley Blind received a blow to the head against Rostov and is a doubt.

Zlatan Ibrahimovic and Ander Herrera are suspended, but Wayne Rooney, Luke Shaw and Anthony Martial could be fit.

Image source, EPA

Here are Sunday's Premier League fixtures and what time they kick-off, so you can plan your day...

Middlesbrough v Manchester United (12:00 GMT)

Tottenham v Southampton (14:15 GMT)

Manchester City v Liverpool (16:30 GMT)

Image source, AFP

Some are screaming for him to go, some are pleading for him to stay. Arsene knows what he's going to do, but what do you think? Will he stay, will he go, will he open a small coffee shop in Shoreditch where homegrown, young waiters pass your drink to each other for 15 minutes but never actually stick it down on the table?

What do you think Arsene Wenger's future holds?

You can contact us using the hashtag #bbcfootball or on text using 81111 (UK only).

Image source, EPA

Tony Pulis has caused Wenger more than a little heartache down the years, but the West Brom boss is fully behind the Frenchman...

“He’s probably the greatest manager Arsenal have ever had but they could still finish in top four and win an FA Cup final and that’s a great deal for Arsenal football club," said Pulis.

“Arsene will recognise the situation he’s in. I still think he’ll stay. He had the opportunity and chance of managing one of the great clubs in the world, a fantastic club. Yes they want (to win) a championship and do better and I think he will believe he can still do that.”

Image source, AFP

Former Spurs manager Harry Redknapp was on Sportsweek this morning. Inevitably, he was asked about Wenger and if he were the Frenchman, would he walk away?

"I would think so, yes," replied Redknapp. "He’s had a fantastic career. He has been a great manager for Arsenal. Everyone has got great respect for him, what he’s achieved over the years.

"Maybe now it is time for a change. Even from Arsenal’s point of view, it’s time for a new brush to come in and brighten the place up.  

"I’d hate for him to get chased out every week by the fans, he doesn’t deserve that but I do think it is time maybe now for a change."

England's highs and lows in Ireland dominates the Mail back page, but they do make mention of Wenger, describing yesterday's defeat as the club hitting an "historic new low". 

Really? Historic new low? Do they not remember the season under Bruce Rioch? Or how about when they were relegated in 1912-13?

Image source, Mail

The Star give Wenger top billing and a pun on the planes flying above the Hawthorns yesterday. Judging by the headline, I think it is safe to say they are not a fan of Arsene keeping his news to himself...

Image source, Star

England's defeat to Ireland in the Six Nations dominates most of the back pages, but there is a whiff of football, mainly focused around Wenger's coyness... 

Image source, EPA

Could it also be game over for Arsene Wenger at Arsenal.

The Gunners boss had another afternoon to forget yesterday as Tony Pulis came back to haunt him again, courtesy of a 3-1 scoreline at the Hawthorns.

There were planes carrying banners overhead - both pro and anti Wenger - and home-made signs in the crowd, pleading for him to go.

After the game, Wenger revealed that he had made a decision on his future, but he wasn't telling just yet. The big tease.