Southampton hand record signing Mario Lemina his debut in midfield.

The £18.1m summer buy from Juventus starts ahead of James Ward-Prowse in the Saints' only change from the 0-0 draw with Swansea.

West Ham make four changes from their 4-0 defeat by Manchester United.

Michail Antonio returns from injury, while Jose Fonte, Aaron Cresswell and 18-year-old Declan Rice are all included in the starting XI.

Angelo Ogbonna, Arthur Masuaku, Pedro Obiang and Edimilson Fernandes drop out.

Image source, bbc

Ian Dennis
Senior football reporter at Anfield for BBC 5 live Sport

Image source, BBC Sport

Liverpool do have a very good record at home on the opening fixture of a Premier League campaign. They've won their opening match in the last four seasons - although Crystal Palace have surprisingly have won on their past three visits to Anfield.

Liverpool with their pace and power will be very much looking forward to this and very much looking to get three points on the board.

Former England internationals Jermaine Jenas and Darren Bent have their say on Philippe Coutinho’s proposed transfer to Barcelona after Liverpool turned down a reported £114m bid.

Mark Schwarzer
Ex-Middlesbrough keeper on Football Focus

Crystal Palace have to take a couple of steps backwards to go back to how they played last season.

If De Boer wants to stick with his system he may have to suffer a few bad results. Sometimes managers change things too quickly and that might be happening at Crystal Palace.

They haven't brought in a lot of players and you have got to have the players to play the system. If he hasn't got ball-playing players you can't enforce it on them.

Gareth Barry makes his West Brom bow.

Southampton hand a debut to record signing Mario Lemina, West Ham start youngster Declan Rice.

Image source, BBC Sport

• Sam Vokes has scored seven goals in his last six Premier League apps after netting just five in the previous 58. The Welsh frontman is also the first Burnley player to score in four consecutive Premier League appearances.
• West Brom have met Burnley four times in the Premier League, winning both home games 4-0 and drawing the two clashes at Turf Moor 2-2.

After midweek Champions League exertions in Germany Jurgen Klopp leaves flying machine Mo Salah on the bench. Andrew Robertson makes his debut.

Full team news to follow.

Image source, BBC Sport

• Bournemouth have conceded 135 goals in the Premier League since they were promoted in 2015, more than any other top-flight side.
• All four meetings between Bournemouth and Watford in the Premier League have ended all square – no Premier League fixture has seen a draw in each of its first five matches.

Juliette Ferrington
BBC Radio 5 live

Image source, BBC Sport

Writing in today's programme, Liverpool boss Jurgen Klopp notes: "Today is our one and only priority. It is where our attention is - 100%.

"The attitude of our players has been outstanding. We have faced challenges during pre-season and at the beginning of the season already. I love that in our squad we have players of different personalities but at their core they all care passionately about what they do, about this club and about each other.

"To achieve something special we all need to put what we can to achieve together ahead of what we might want for ourselves as individuals."

I wonder what he means by that?

Leon Osman
Ex-Everton midfielder on Football Focus

I think Coutinho will go. Barcelona seem to really want their man and usually when a team like Barca comes knocking they end up getting the player.

Liverpool are determined to keep him and are in the driving seat. You just don't know.

Burnley coach Sean Dyche tells us where his love of handmade leather shoes comes from. And remembers the Manchester rave scene.

Just your average manager chat really...

Match of the Day's Ian Wright reveals his tips for the Premier League title, who will win the golden boot, and the summer's best signing so far.

Watch Match of the Day on iPlayer.

Leon Osman
Ex-Everton midfielder on Football Focus

I am concerned about Palace with the noises that are coming out. Scott Dann said he has been asked to get on the ball and they are opening themselves up defensively. To come and make such a big step to a team that are not used to it is asking a lot.

Jonathan Overend
BBC Radio 5 live at St Mary's

Well, after ploughing through a major traffic jam to get here, I’ve just had a look at today’s programme.

The man on the cover is James Ward-Prowse. A rather cruel reminder to Saints fans that he was the last Southampton player to score here – way back on 5 April.

I’ll be providing updates from the match this afternoon on 5 live.

Time will tell whether Liverpool do eventually sell Philippe Coutinho to Barcelona, or Leeds sell Chris Wood, but what I want to know is:

Who is your team's irreplaceable player?

Image source, Getty Images

No matter what division your team plays in, who is the one player you wouldn't sell, even for a King's ransom, and why?

Let us know on text at 81111 (UK Only) or on #bbcfootball on twitter on Instagram.

Image source, Getty Images

Jonathan Overend
BBC Radio 5 live

Southampton’s ground looking in superb condition – note the goal in the photo. Sadly for home fans, that hasn’t been employed by the home team since they played Palace on 5 April. That is six Premier League games and counting…..

Ian Dennis
Senior football reporter for BBC 5 live

Image source, PA

Burnley are close to signing striker Chris Wood from Leeds United for a fee of around £15m.

He's due to undergo a medical tomorrow and the deal is expected to be completed early next week.

Image source, Getty Images

West Brom are interested in Liverpool's £30m-rated defender Mamadou Sakho.

France centre-back Sakho, 27, is out of favour at Anfield after falling out with Reds manager Jurgen Klopp on the 2016 pre-season tour of the USA.

He was sent on loan to Crystal Palace last season, where he made eight appearances, and was nominated for their player of the year award.

The news comes after the Baggies rejected an £18m bid from Manchester City for centre-back Jonny Evans.

Manager Tony Pulis said on Friday it would be "crazy" to say they would turn down a bigger offer for the Northern Ireland defender, but added: "We're not desperate for money."

We'll bring you team news from all five of our 15:00 BST kick-offs shortly after 14:00 BST. Any debutants on display? Any people appearing for the last time?

Let's have a look at some transfer rumours circulating this afternoon...