James McClean is too heavy with a tackle and goes into the book. He'll miss Ireland's next match.

Image source, Reuters

A change for each side. Ireland chuck on winger Callum O'Dowda for Stephen Ward, while Serbia replace Filip Kostic with Stefan Mitrovic.

John Hartson
Former Wales striker in Chisinau

This is constant, constant pressure from Wales, they just need a little break, a bounce of a ball, anything to get the elusive goal.

Image source, Reuters

Chaos at the back for Moldova. The home keeper dives out unnecessarily to meet a cross from the left and the ball deflects between him and one of his own defenders. It leads to a mad scramble to hack clear.

After a rather considerable delay Robbie Brady hits the free-kick, which he frustratingly drives straight into the wall.

Seconds later he is booked for a dubious foul on Aleksandar Mitrovic and will miss the next game.

Sam Vokes is on for Andy King. And he goes close for Wales. Ben Woodburn is the creative force with a flick that releases Ben Davies down the left. His low cross is cut out and put behind for a corner that the big striker meets and heads wide.

Nikola Maksimovic gets this all wrong - scything down Daryl Murphy, who is through on goal but outside the penalty area. About 25 yards from goal - the Republic have a free-kick....

Image source, Reuters

The Republic of Ireland have never lost a competitive match in Dublin under Martin O'Neill.....that record is under increasing peril.

You can feel the nerves starting to grip some Wales players. Mistakes are creeping in. Fear of failure starting to dictate.

Image source, PA

The Republic need to summon up a response or their World Cup qualification hopes are going to be left in serious peril.

Martin O'Neill has played his first card by introducing big Daryl Murphy for Hoolahan.

The Norwich 35-year-old has been excellent tonight but he was always unlikely to last the full 90 and a bit minutes.

A second of the game for Celta Vigo striker Iago Aspas too.

Spain now 7-0 up on Liechtenstein.

A second for Everton's Gylfi Sigurdsson too as Iceland lead Ukraine 2-0.

25 minutes left.

Almost a disaster for Wales. Ashley Williams pulls out of tackle, allowing Gheorghe Anton to run in on Wayne Hennessey. Out comes the Wales keeper and it is enough to put off the Moldovan, whose poked effort dribbles wide via a deflection.

From the resulting corner, Radu Ginsari rises but heads over.

Dafydd Pritchard
BBC Sport Wales in Chisinau

It has now been more than four minutes since Ben Woodburn came on and the 17-year-old still hasn't scored.

The Liverpool youngster has let his standards drop since Saturday.

John Hartson
Former Wales striker in Chisinau

Will Chris Coleman throw Sam Vokes on too?

They will then have Hal Robson-Kanu on as well, allowing Wales to go a little more direct.

Striker for midfielder. Daryl Murphy replaces Wes Hoolahan for the Republic of Ireland. Wind, meet caution.

Ben Woodburn tries to pick out Hal Robson-Kanu in the box but his chipped cross floats agonisingly ahead of his fellow striker.

Image source, Reuters

Here comes Ben Woodburn.

The Liverpool teenager replaces Tom Lawrence.

Can lightning strike twice?

Image source, Reuters

Over the boundary...and six.

Chelsea's £60m man Alvaro Morata has netted his second of the game for Spain and they now lead Liechtenstein 6-0.

Still 35 minutes remaining in that game.

Meanwhile, Iceland have hopped above Ukraine into second place in Group I. Everton midfielder Gylfi Sigurdsson the goalscorer for the hosts.

So Group D as is stands looks like this...

Serbia - 18 points

Republic of Ireland - 13 points

Wales - 12 points

In other words, looking good for Serbia.