Chelsea manager Maurizio Sarri makes several changes to the XI that started in the FA Cup defeat against Manchester United on Monday..

The Italian has opted for Willy Caballero as the replacement for injured goalkeeper Kepa Arrizabalaga.

Forward Pedro misses out with a stomach bug and is replaced by Willian.

Andreas Christensen comes in for David Luiz in defence and Emerson replaces full-back Marcos Alonso.

Eden Hazard and Gonzalo Higuain are both on the bench with Callum Hudson-Odoi and Olivier Giroud coming into the attack.

Full-back Davide Zappacosta has failed to recover from a fever.

Patson Daka has struck twice to help Red Bull Salzburg to a 3-0 lead against Club Brugge, and 4-2 on aggregate.

Sporting Lisbon have scored at Villarreal to make it 1-1 on aggregate while Fenerbahce have pulled one back away to Zenit St Petersburg, making the aggregate score 2-2.

And Napoli look to be heading through having gone 1-0 up on the night and 4-1 up on aggregate against FC Zurich.

Away we go in London and in Spain...

I've just checked and the away goals rule comes into force before any period of extra time. So, should Bate score and the game finished 2-1 after 90 minutes, the Belarusians would be through.

Only Granit Xhaka played more passes in that first half than Mesut Ozil. He was not on the fringes, that's for sure.

Alasdair Lamont
BBC Sport Scotland in the Mestalla

Valencia began to turn the screw at the end of the half following Toljan’s ordering-off and only Scott Bain kept the scoreline goal-less.

You have to feel for Celtic, who put so much into that first half only to have the wind taken out of their sails with the red card.

Image source, Reuters

Chelsea have had more shots (147) and completed over 400 more passes (4642) than any other team in the Europa League this season.

Hands up if you 've been dying to see N'Golo Kante in the middle of Chelsea's midfield three?

You may get your wish tonight as Jorginho has been dropped/rested.

Although in the last half hour last week in Sweden we thought that and Sarri just moved Kovacic into the 'Jorginho role.'

Kyle: A red card for Celtic which isn't Scott Brown. That's the shock of the night so far. Though there is still time and i wouldn't be surprised if he got dismissed still and they ended up down to 9 men. Celtic had little chance before they have no chance now.

Celtic have played well in patches - but they are now down to 10 men and surely heading out.

Jon Ryan: Let’s get this clear this isn’t a Wenger team it’s an Emery team. When AW was in charge we won 10-4 on aggregate.

So far, so good for the Gunners.

Christopher David: Ahh clever, Arsenal. All those rubbish short corners were to give BATE a false sense of security and to lower their guard. Genius.

Bradley Bicknell: As bad as Arsenal’s defenders are, they do get you a goal.

A small guitar or banjo? Ukulele?

Not Jamesy: Dear ManUtd we'll give you Mhky in return for Sanchez?! Yours sincerely Arsenal (fans).

Kyle: Teams like Salzburg, Napoli and a few others will destroy Arsenal with the shambles they have in defence even if they played Chelsea over 2 legs I still think Chelsea despite the current mess they are in will beat them.

Well this is an easy update. You know all those teams that were leading 1-0 on the night... they're all now 2-0 up!

So that's Red Bull Salzburg, Eintracht Frankfurt, Dinamo Zagreb and Zenit St Petersburg all now leading on aggregate.

The red card did look harsh to me. What a save that is! Scott Bain going full stretch to tip away a deflected shot from Dani Parejo. Celtic up against it now.

Image source, Reuters

Pat Bonner
Former Celtic goalkeeper on BBC Sportsound