Postpublished at 14:26 Greenwich Mean Time 13 December 2021
Now for a few stats around some of those matches...
Manchester United will face Atletico Madrid in European competition for the first time since November 1991, when they were eliminated by the Spaniards in the second round of the European Cup Winners' Cup.
If memory serves Atletico scored two late goals to win the first leg 3-0 in Spain.
Manchester City play Sporting Lisbon for the first time since the 2011-12 Europa League last 16, with the Portuguese side winning on away goals back then.
Chelsea have won each of their last four meetings with French sides in all European competitions (including twice vs Lille), having won just five of their first 16 such games.