Postpublished at 15:19 Greenwich Mean Time 8 January 2022
Barnsley 0-0 Barrow
Barnsley are enjoying the better of this one. Callum Brittain with the best effort so far, which was well saved by Paul Farman.
Everton, Southampton and Plymouth through after extra time in day's late games
League One Cambridge Utd stun Newcastle - arguably day's biggest shock
National League North Kidderminster bridge four-division gap to beat Reading
National League Boreham Wood beat AFC Wimbledon
Championship side Huddersfield win 2-1 at Burnley
Every goal across the weekend available on BBC Sport app
Michael Emons, Gary Rose and Harry Poole
Barnsley 0-0 Barrow
Barnsley are enjoying the better of this one. Callum Brittain with the best effort so far, which was well saved by Paul Farman.
Leicester City 1-0 Watford
Hamza Choudhury pings it over to Harvey Barnes on the left. The Leicester winger tries to cut inside and into the box but he's quickly surrounded.
Newcastle 0-0 Cambridge
Jacob Murphy is allowed to dribble into the box and picks out Allan Saint-Maximin at the back post, but he can't keep the header down.
Peterborough 0-0 Bristol Rovers
Nathan Thompson strikes at goal for Peterborough but Bristol Rovers' goalkeeper James Belshaw does well to keep it out.
FT: Millwall 1-2 Crystal Palace
Millwall boss Gary Rowett to ITV: "I thought we played really well for most of the game. I thought the first half was a really good performance in many ways, both on the ball and off the ball I thought we were excellent.
"We concede a really poor goal in the 46th minute – you can’t do that against Premier League opposition. Olise is a really good player and you’ve got to force him on to his right foot.
"The second goal, again, it’s a ball into the box, it’s a header that we’ve got to go and mark and then we had moments ourselves.
"I thought we stayed in the game quite well but you can’t give two goals to a Premier League side and that’s the disappointing thing."
Port Vale 0-0 Brentford
Still pretty even at Vale Park between the League Two hosts and Premier League Brentford. The hosts are looking to put the Bees' new goalkeeper Jonas Lossl under pressure at every opportunity and look well up for this challenge. It looks like it could be a tricky afternoon for Thomas Frank's men...
Jeff taking a long time to say "play the kids"
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As a Watford fan we must not be involved in the FA Cup. It's essential to put up a vague imitation of a fight but even more important that we be free to concentrate on the league. Thus an early penalty is not really a disappointment. Leicester are the cornerstone of my afternoon's punting.
Jeff in Maidenhead
Wigan 0-0 Blackburn
John Buckley has an effort for Blackburn but his effort is tipped around the post by home goalkeeper Jamie Jones, with the resulting corner coming to nothing.
But Buckley may have been better off knocking a square pass to Chile international Ben Brererton Diaz, who would have had a tap-in. Still goalless.
Newcastle 0-0 Cambridge
The Premier League side give it away and strong running from James Brophy wins Cambridge a corner. It's delivered to the back post, where George Williams gets up but heads straight at Martin Dubravka.
Leicester City 1-0 Watford
Watford have grown into the game in the last few minutes. It's whipped in from the right and Ozan Tufan slices it over the bar. It was behind him to be fair.
Kidderminster 0-0 Reading
Reading's 18-year-old forward Mamadi Camara is denied as he gets into the area but sees his close-range shot smothered by goalkeeper Luke Simpson.
FT: Burnley 1-2 Huddersfield
Huddersfield Town
Huddersfield manager Carlos Corberan: "I have a squad that I trust and it's a shame I can only pick 16 outfielders in any squad, because I saw interesting things from a number of players today.
"It's special to have seven games without losing. It tells us that the players are competing really well and I want to see that continue. Of course the dynamic of the game is positive but I know as a coach we'll have tough moments and good moments.
"There are things we have to continue improving and have the stability to keep changing situations."
On the travelling fans: "They were pushing us all the way and helping us to keep going. It felt like we were playing at home today and we wanted to give something special to our fans."
Peterborough 0-0 Bristol Rovers
Peterborough nearly got an early goal in their tie against Bristol Rovers, but Sammie Szmodics hit a powerful shot narrowly wide.
That's the closest we've come to a goal in that one so far.
Leicester City 1-0 Watford
Joao Pedro puts Youri Tielemans under intense pressure on the left. The Leicester midfielder slips but recovers and manages to poke it back to Danny Ward in goal.
QPR 0-0 Rotherham
20 places separate these two, who were Championship opponents last season.
It's been a quiet start between QPR and the League One leaders, but Albert Adomah has given the crowd a good laugh after making a complete mess of an attempted quick throw-in.
FT: Mansfield 2-3 Middlesbrough
Middlesbrough boss Chris Wilder told BBC Tees: "I thought we got right out of the blocks and I have to give enormous credit to Mansfield Town, their manager, players and supporters because it's difficult going 2-0 down, but their team rallied and I knew this was going to be a really difficult afternoon, and so it proved to be.
"The result is the main thing and we have got through a really tough tie.
"We can play better but they are on a great run and any Championship team would have struggled today. We had a fight and struggled to get through but eventually we did."
Newcastle 0-0 Cambridge
Allan Saint-Maximin goes on one of those marauding runs and fires wide from outside the box.
More good footwork from the winger then picks out Joelinton, but he stumbles on the edge of the area as he goes to hit it.
FT: Millwall 1-2 Crystal Palace
Crystal Palace
Crystal Palace goalscorer Michael Olise to ITV: "It was a tough start to the game and at half-time we said we needed to respond and show more fight – and we did that in the second half. We did what we know how to do and the quality came through.
"The gaffer just told us to go out there, express ourselves and play well, fight – and that’s we did. The Palace fans were great throughout the whole game, the atmosphere was great."
West Brom 0-0 Brighton
West Brom have started off as the better side. Matt Phillips has a go from long range but it's over the bar.