Despite having to go up against his friend Pep Guardiola, Mikel Arteta is relishing how Arsenal are competing with City for trophies.

"I always hoped that was going to be the case one day and it's happening this season," he said.

"That's not going to change any friendship, the moments that we have, how important he is in my life, how important he is in my profession.

"We're both willing to win and defend our clubs in any way and that's always been the case since day one.

"I would prefer to do it with someone else to be fair."

"I think Pep should smile a bit more and that's coming from me," says Roy Keane on ITV's coverage...

Peter: Re Andy 19:29 Arsenal don’t play again for 8 days. No need to rest anyone. This indicates a lack of ambition.

Edwin Makokha: The lineup from Manchester City is clear the priority is FA Cup. Guardiola knows something to do with the Premier League that ordinary mortals may not know.

Image source, Getty Images

A bit of transfer news for you today.

Brighton have rejected a £60m bid from Arsenal for 21-year-old Ecuador midfielder Moises Caicedo.

The Premier League leaders are keen to strengthen their squad after Mohamed Elneny picked up an injury in training that could mean a lengthy lay-off.

Arsenal already have a small squad and manager Mikel Arteta does not want to jeopardise his team's title challenge through a lack of numbers.

Earlier this month, Arsenal signed Leandro Trossard from Albion for £21m and so they do not have a financial reason to sell Caicedo.

In their last FA Cup meeting in 2020, Pierre-Emerick Aubameyang scored both goals in Arsenal's 2-0 semi-final victory.

Arsenal and Manchester City take a break from battling it out for the Premier League title, so they can battle it out for the FA Cup instead.

After tonight (unless they draw...) only one will have dreams of a league and cup double.

Image source, .

Manchester City boss Pep Guardiola has said Arsenal's Mikel Arteta had "a great, massive influence" on him and helped him become a better manager.

Arteta was Guardiola's assistant at City before taking the Arsenal job.

The Gunners lead the Premier League, with reigning champions City second.

"I had the feeling, we knew it when he was here, (about his ability for City," said Guardiola.

"I don't know my part on him but his influence on me was great, massive, so important in becoming a better manager.

"If I had left, Mikel would be here and he would be the best, absolutely.

"I know he went to 'his' club, the team he dreams of. He's a supporter, for the fact he played there, he was a captain there. He loves the club.

"I remember when we were together here, when we scored goals, he'd jump a lot and celebrate - except against one team, Arsenal."

Chris Sutton
BBC football expert

Image source, .

This is a brilliant tie to get the fourth round started and it is going to be interesting to see how both managers approach it, because they meet again in the Premier League in the middle of February.

City boss Pep Guardiola always selects strong teams in the domestic cups, but we don't know how big Arsenal manager Mikel Arteta will go, given his side's position at the top of the table.

The FA Cup clearly won't be Arteta's priority, but his side have got so much momentum at the moment while City are still not at their fluid best.

I am sure it will be all smiles between the pair of them beforehand, because Arteta was one of Guardiola's assistants at City before taking the Gunners job, but this is going to be a fiercely fought contest - which I think City will edge.

Sutton's prediction: 2-1

Read all of this weekend's predictions here

Clinton Morrison
Former Republic of Ireland striker on BBC Radio 5 Live

It is all mind games for me. If Arsenal lose, Mikel Arteta can come out and say "well we didn't have our strongest team out there".

It is a big game for Manchester City. They need to beat Arsenal.

Manchester City blasted Chelsea 4-0 in the last round.

Arsenal, well I don't think they played a third-round game. I certainly can't remember it.

The internet says they beat Oxford 3-0 but that doesn't sound likely.

Oh by the way, did I mention that I'm an Oxford United fan?

There's one non-league left in this season's FA Cup, Wrexham.

Read about how their owners Rob McElhenney, the creator of the greatest TV show of all time It's Always Sunny in Philadelphia, and Ryan Reynolds, who does films, have transformed the club.

They play Sheffield United on Sunday, live on BBC One.

You've seen the teams. Now let us know who you think will win tonight.

Thumbs up for Manchester City.

Thumbs down for Arsenal.

Image source, @ManCity

Manchester City make two changes to the side that beat Wolves 3-0 in the Premier League last weekend as Stefan Ortega replaces Ederson in goal and Nathan Ake returns in place of Aymeric Laporte.

Man City XI: Ortega, Lewis, Stones, Akanji, Ake, Rodrigo, De Bruyne, Gundogan, Mahrez, Grealish, Haaland.

Subs: Ederson, Walker, Dias, Phillips, Cancelo, Laporte, Alvarez, Silva, Palmer.

Image source, @Arsenal

Arsenal make six changes to the side that recorded a 3-2 home win over Manchester United in the Premier League last weekend.

Matt Turner replaces Aaron Ramsdale in goal while Takehiro Tomiyasu, Rob Holding and Kieran Tierney come into the back four at the expense of Ben White, William Saliba and Oleksandr Zinchenko.

Fabio Vieira comes in for Martin Odegaard and Leandro Trossard makes his first start for the Gunners in place of Gabriel Martinelli.

Arsenal XI: Turner, Tomiyasu, Holding, Gabriel, Tierney, Vieira, Partey, Xhaka, Saka, Nketiah, Trossard.

Subs: Ramsdale, White, Zinchenko, Saliba, Kiwior, Lokonga, Odegaard, Marquinhos, Martinelli.

BBC Radio Manchester

You can listen to full commentary of this game on BBC Radio Manchester - which is available on this page, or the BBC Sounds app.

There will be updates on BBC Radio 5 Live's Friday Football Social but not full commentary.

Image source, .

The draw for the fifth round takes place on Monday, 30 January live on The One Show on BBC One from 19:00 GMT.

The FA Cup final will take place at Wembley on 3 June, six days after the Premier League season ends and a week before the Champions League final.

I've just seen the line-ups. Strong but not the first XI for either side.

Full team news on its way soon.

Only 11 of the 20 Premier League made it through the third round.

At least two more top flight clubs will go out this weekend.

That is because Manchester City-Arsenal and Brighton-Liverpool meet in all-Premier League ties.

So at least seven of the 16 teams in the fifth round will be Football League or non-league.

Here's some stuff that happened in the last round.

Friday

Manchester City v Arsenal, 20:00 - live on ITV1, ITVX.

Saturday

Accrington Stanley v Leeds United, 12:30 - live on BBC One, iPlayer, BBC Sport website & app.

Walsall v Leicester City, 12:30 - live on Red Button, BBC iPlayer, BBC Sport website & app.

Preston North End v Tottenham Hotspur, 18:00 - live on BBC One, iPlayer, BBC Sport website & app.

Manchester United v Reading, 20:00 - live on ITV4, ITVX.

Sunday

Brighton & Hove Albion v Liverpool, 13:30 - live on ITV1, ITVX.

Wrexham v Sheffield United, 16:30 - live on BBC One, iPlayer, BBC Sport website & app.

Monday

Derby County v West Ham United, 19:45 - live on ITV4, ITVX.