Harlequins fly-half Nick Evans gets us started at The Twickenham Stoop.

The players have taken to the field in this crunch match.

Just a reminder of what's at stake...

Exeter need a win to guarantee them second spot while Harlequins require a bonus-point victory to cement their place in the Champions Cup next season.

Stuart Lancaster
Ex-England coach on BBC Radio 5 live sports extra

On Danny Cipriani's time at Sale and move back to Wasps: "Danny has definitely benefited from Paul Deacon’s coaching. He’s brought the structure into the Sale side and him and Peter Stringer have really made the team tick.

"They’ve got Danny back on track after his trip to the Southern hemisphere but the lure for Danny to go back to his home club was too strong."

Image source, BBC Sport

England full-back Mike Brown returns as Harlequins make seven changes in their bid to secure a European Champions Cup spot.

Exeter Chiefs, who need to win to guarantee second place, make six changes as Thomas Waldrom returns to number eight.  

Harlequins: Brown; Yarde, Stanley, Roberts, Chisholm; Evans, Care (capt); Lambert, Ward, Collier, Merrick, Matthews, Robshaw, Clifford, Easter.

Exeter Chiefs: Dollman; Nowell, Slade, Hill, Short; Steenson, Chudley; Hepburn, Yeandle (capt), Williams, Lees, Welch, Ewers, Salvi, Waldrom.

Click here for our full preview.

Image source, BBC Sport

Bath hand scrum-half Will Homer his first Premiership start, while wing Semesa Rokoduguni returns after missing last week's loss at Northampton to play for the Army.

Back-rowers Tom Croft and Jordan Crane start as Leicester Tigers make a string of changes with a Premiership semi-final spot secured.

Bath: Watson; Rokoduguni, Joseph, Devoto, Banahan; Ford, Homer; Catt, Webber, Wilson, Ewels, Attwood, Garvey, Louw (capt), Denton.

Leicester Tigers: Tait; Thompstone, Betham, Roberts, Catchpole; Williams, B. Youngs; Genge, Ghiraldini, Balmain, Slater (capt), De Chaves, Croft, Evans, Crane.

Click here for our full preview.

Image source, BBC Sport

England captain Dylan Hartley is set for his first appearance in seven weeks after being named on the bench by Northampton Saints, whose starting XV remains unchanged.

Gloucester wing Elliot Creed, 19, will make his first senior start having come through the Cherry and Whites' academy.

Gloucester: Marshall; Thorley, Twelvetrees, Atkinson, Creed; Laidlaw (capt), Heinz; Thomas, Hibbard, Afoa, Savage, Thrush, Moriarty, Kvesic, Morgan.

Northampton Saints: Mallinder; K Pisi, G Pisi Burrell, North; Myler, Dickson (capt); Waller, Haywood, Brookes, Lawes, Day, Gibson, Wood, Harrison.

Click here for our full preview.

Image source, BBC Sport

Dean Ryan makes five changes to the side which lost at Leicester last week in the Warriors' final fixture before switching to an artificial surface.

Saracens hooker Jamie George returns following a two-month lay-off with a bicep injury, one of eight changes to the side which beat Newcastle.

Worcester Warriors: Pennell; Heem, Symons, Mills, Vuna; Heathcote, Baldwin; Leleimalefaga, Annett, Schonert, O'Callaghan, Sanderson, Betty, Kirwan, Dowson (capt).

Saracens: Goode; Ashton, Bosch, Tompkins, Wyles; Hodgson (capt), de Kock; Barrington, George, Du Plessis, Kruis, Hamilton, Wray, Brown, Vunisa.

Click here for our full preview.

Image source, BBC Sport

Newcastle Falcons have made seven changes to the side that lost at Saracens for the final game of the season.

Sale Sharks make one change, with prop Eifion Lewis-Roberts replacing Ross Harrison in the front row.

Newcastle Falcons: Hammersley; Tait, Harris, Socino, Watson; Delany, Young; Vickers, Hawkins, Cusack, Green, Witty, Wilson, Temm, Latu (capt).

Sale Sharks: Haley; Addison, James, Leota, Edwards; Cipriani, Stringer; Lewis-Roberts, Taylor, Cobilas, Evans, Ostrikov, Neild, Seymour (capt), Ioane.

Click here for our full preview.

Image source, BBC Sport

Wasps have the departing Ruaridh Jackson at stand-off, while Josh Bassett comes in on the wing for Frank Halai.

London Irish bring back twice World Cup winner Ben Franks for his first start since January at tight-head prop.

Wasps: C Piutau; Wade, Daly, S Piutau, Bassett; Jackson, Simpson; Mullan, Johnson, Cittadini, Launchbury, Davies, Haskell (capt), Young, Hughes.

London Irish: Tonks; Lewington, Mulchrone, Williams, Tikoirotuma; Brophy Clews, McKibbin; Harris, Paice, Franks, Stooke, Symons, Narraway (capt), Trayfoot, Treviranus.

Click here for our full preview.

BBC Radio Bristol's Andrew Sheridan on Bath's season: "It’s been a disastrous season from a Bath perspective - that is what you can bluntly say.

"The Sam Burgess debacle had a much great impact on the club than many thought. There were casualties, like Carl Ferns who left the club, it didn’t go down terribly well and I’m not sure they every really recovered from that."

Cross-code convert Sam Burgess left Bath before the start of the season to return to rugby league club South Sydney Rabbitohs. Burgess, who featured for England at last year's rugby World Cup, had two years left on a three-year deal.

One game with nothing on it this afternoon is the one being played at Sixways, where table-topping Saracens visit already-safe Worcester Warriors.

Finishing first in the Premiership may not offer up any silverware, but Sarries director of rugby Mark McCall says it's an achievement to be proud of nonetheless.

Image source, Getty Images

"We are very proud of the fact that we have come top of the table for the third time in four years," he tells BBC Radio 5 live sports extra. "We talk a lot as a group about not picking and choosing and fronting up every week.

"We have used close to 50 players this year, and a lot of that is to try to get to this point of the season with our starting 23 physically and mentally fresh and enthusiastic for the games ahead."

Full-back Chris Pennell will be lining up for Worcester Warriors as they take on top-of-the-table Saracens in the Premiership - despite being a type 1 diabetic, external.

Here, in this exclusive Get Inspired video, Chris takes us through a day in his life as a professional rugby player with diabetes.

Director of rugby Conor O'Shea will lead Harlequins out in a Premiership match for the final time today, with the Irishman set to become Italy head coach in the summer.

His swansong will come in next Friday's European Challenge Cup final and, judging by his comments on BBC Radio 5 live sports extra, it promises to be an emotional one.

Image source, Getty Images

"I love the place and it's been six years of my life," he says. "My daughter was three or four months old when we joined here - she's now six and a half and is asking 'can we still support Harlequins?' I said there's no problem with that, that can be her team for life.

"It's a great club. I've always said the game is never about coaches, and the day coaches believe it's about them is a sad day. It's about the players, who sacrifice so much.

"I'm really excited about [the Italy job], but I'll think about it when it comes. I will leave Harlequins with so many friends, which sometimes in sport you don't get a chance to do."

Stuart Lancaster
Ex-England coach on BBC Radio 5 live sports extra

"Sale have a huge amount to play for and psychologically they will be absolutely ready for this game. I think you can underestimate the pride of Newcastle playing at home. I've been here lots of times over they year and with Dean Richards at the helm, they will want to perform in front of a home crowd.

"On the artificial surface it will be a real opportunity to entertain what will be a big crowd today."

A reminder - Sale, who are a point behind Harlequins in seventh, can still grab the final Champions Cup place if they can beat Newcastle and either Northampton or Harlequins lose.

With the play-offs already out of Northampton Saints' reach, today brings about the end of a gruelling domestic campaign for wing George North.

The Welshman, who revealed during the week that he had considered making himself available for Team GB's Olympic rugby sevens team, says he is looking forward to "finishing on a high".

Image source, Getty Images

"I'm feeling alright and still in one piece," he tells BBC Radio 5 live sports extra. "It's the season that never ends. We have everything to play for now to try to stay in the top six.

"I think you can class our season as inconsistent. We have shown glimpses of some awesome rugby that can challenge the best in Europe, and sometimes we couldn't have played worse. Our goal now is to win this afternoon, finish the season on a high, and finish in the top six."

Image source, @bbcrugbyunion

Whether you want to discuss the season as a whole or just talk up your team's chances in round 22, you can get in touch with us throughout the afternoon by using #bbcrugby on Twitter.

And, if you're not already, you can also follow @bbcrugbyunion, external for all the latest news from the world of rugby union.