Image source, Rex Features

We're on the home straight in the regular season, but many questions remain unanswered.

Who will finish in the top two, and get home advantage in the play-off semi-finals?

Who will grab the final play-off spot? Leicester or Bath? 

Harlequins rose to sixth last night, but can they stay in the last European Champions Cup qualification place? Or will Northampton or Gloucester get there?

Anything you'd like to talk about this afternoon get in touch using #bbcrugby on social media.

Sale make four changes with ex-Tiger Laurence Pearce replacing captain Josh Beaumont who has a shoulder problem.

England call-up Tom Curry replaces twin brother Ben, Kieran Longbottom comes in after Halani Aulika broke his arm and Josh Charnley is back on the wing.

Portugal prop Diogo Ferreira, 20 could make his debut if he comes on from the bench. 

Sale: Haley; Solomona, James, Jennings, Charnlry; MacGinty, Phillips; Harrison, Webber (capt), Longbottom, Evans, Ostrikov, Neild, T Curry, Pearce. 

Replacements: B Curry, Flynn, Ferreira, Nott, Seymour, Stringer, Leota, McGuigan.

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Lock Graham Kitchener and winger Adam Thompstone will make their 100th starts for Leicester Tigers.

Tom Youngs returns in their pack, while Owen Williams starts at centre and Mathew Tait comes in at full-back.

Leicester: Tait; Thompstone, Roberts, O Williams, Pietersen; Burns, B Youngs; Genge, T Youngs (capt), Cole, Barrow, Kitchener, M Williams, O'Connor, Hamilton.

Replacements: G McGuigan, Bateman, Balmain, Fitzgerald, Thacker, Harrison, Smith, Betham.

• If Exeter win and Saracens lose, the Chiefs and Wasps will have home play-off semi-finals
• If Exeter and Saracens win, the home semi-final place will be decided in the final round
• If Leicester win and Bath lose tomorrow, the Tigers will be confirmed in the final play-off place
• If Northampton lose today and Bath win tomorrow, the West Country side will have confirmed a top six place

Image source, Rex Features

Already-relegated Bristol make two changes for their trip to Saracens, as Jack O'Connell comes into the front row and Ollie Robinson returns to the back row.

The visitors could give a debut to prop Ollie Dawe from the replacements bench.

Bristol: Woodward; Edwards, Hurrell, Henson, Tovey; Searle, Mathewson; O'Connell, Jones (capt), Cortes, Phillips, Sorenson, Jeffries, Robinson, Eadie.

Replacements: Crumpton, Dawe, Ford-Robinson, Glynn, Fenton-Wells, Williams, Pisi, Piutau.

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Saracens captain Brad Barritt misses the game with a knock, so Owen Farrell takes the armband and Alex Lozowski starts at centre against Bristol.

Sarries hope to better second-placed Exeter's result against Saints as they battle for a home play-off semi-final.

Veteran forward Kelly Brown and scrum-half Neil De Kock will make what could be their final appearances for Saracens at the Allianz after distinguished careers with the club.  

Saracens: Goode, Ashton, Tomkins, Lozowski, Wyles; Farrell (capt), De Kock; M Vunipola, Brits, Koch; Itoje, Kruis; Brown, Burger, B Vunipola.

Replacements: George, Lamositele, Du Plessis, Hamilton, Earl, Wigglesworth, Gallagher, Ellery.

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The top three look to be sorted, but the issue of who will get the home play-off semi-finals could become clearer today.

There is still a fight to get that final place within the top four, and Northampton, and Gloucester, are part of the chasing pack trying to secure Champions Cup rugby next season.

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There's been a late change to the Northampton side, with skipper Tom Wood missing from the starting XV with a shoulder problem.

Courtney Lawes has shifted across to flanker, with Christian Day coming into the second row.

Saints make three changes in all to the side which was narrowly beaten by Saracens a fortnight ago.

Louis Picamoles and Stephen Myler are on the treatment table, with Teimana Harrison and JJ Hanrahan starting.

Northampton: Tuala; Pisi, Burrell, Mallinder, Foden; Hanrahan, Groom; Waller, Hartley, Brookes, Day, Ribbans, Gibson, Lawes, Harrison.

Replacements: Haywood, Ma'afu, Denman, Ratuniyarawa, Dickinson, Dickson, Tuitavake, Estelles.

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Exeter half-backs Henry Slade and Jack Maunder, called up by England last week, miss the game with Northampton through injury, with Stu Townsend and Gareth Steenson coming in.

Wing Jack Nowell returns in place of James Short, while Michele Campagnaro is replaced at centre by Ian Whitten as Chiefs look to secure a home semi-final in the play-offs.

Exeter: Turner; Nowell, Whitten, Devoto, Woodburn; Steenson, Townsend; Rimmer, Yeandle (capt), Holmes, Dennis, Parling, Ewers, Armand, Horstmann.

Replacements: Cowan-Dickie, Moon, Williams, Atkins, Salvi, Chudley, Simmonds, Hill.

• Exeter v Northampton
• Leicester v Sale
• Saracens v Bristol

Each game kicks off at 15:00 BST so we'll keep you up-to-date as they progress.

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There were two games that got round 21 going last night.

In his final appearance at the Stoop before retirement, Nick Evans kicked 22 points as Harlequins beat league leaders Wasps 32-13 and boosted their chances of a top six finish.

Meanwhile, in the North East, Sonatane Takulua scored all of Newcastle's points to beat Worcester 16-14 to record their ninth win of the season.

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As rugby enthusiasts, what is the one thing we all want approaching the climax of the Premiership season?

Games that have something riding on them - that would be my answer anyway.

All three matches this afternoon fit that bill, none more so Northampton's trip to Exeter - Saints are in the hunt for European Champions Cup qualification, while Chiefs want that home play-off semi-final.

Saracens have the same aim as they host relegated Bristol, while Leicester can take a big step towards the final play-off place if they beat Sale.

We'll be describing all the action as well as telling you what it all means.