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Ollie Lawrence, Kyle Sinckler and Anthony Watson score but Farrell misses four kicks
Louis Rees-Zammit briefly gave Wales lead early in second-half
England in third place behind Scotland on points difference
Wales remain bottom of Six Nations after three defeats
Game went ahead only after crisis meeting averted Wales players' strike
Wales v England (16:45 GMT)
Welsh mezzo-soprano Katherine Jenkins is performing World in Union as part of the pre-match entertainment.
Can you believe it was 20 years since she first sang here and doesn't look a day older!
Image source, Huw Evans Picture AgencyWales v England (16:45 GMT)
Sam Warburton
Former Wales captain on BBC One
Mason Grady is big, tall, aggressive, has great skills, even if he doesn't play well today give him time in a 13 shirt and he could be a main stay for us for many many years to come.
Image source, Huw Evans Picture AgencyWales v England (16:45 GMT)
Fans at Colwyn Bay were treated to a corker of a match between Wales and England Under 20s last night.
England came away with a 37-21 victory, making it three wins from three.
Despite their efforts, Wales remain winless and rooted to the bottom of the table.
Image source, Huw Evans Picture AgencyWales v England (16:45 GMT)
Watch the best tries from the first two rounds of this year's Six Nations.
Let's hope for more of the same today.
Wales v England (16:45 GMT)
Guernsey Male Voice Choir and Côr Meibion Pendyrus are belting out Sospan Bach as the stadium begins to fill.
They're joined on the pitch by the Regimental Band Corps of Drums of the Royal Welsh.
Wales v England (16:45 GMT)
You can't beat matchday in Cardiff.
The fans are ready, are you?
Image source, Huw Evans Picture Agency
Image source, Huw Evans Picture Agency
Image source, Huw Evans Picture Agency
Image source, Huw Evans Picture AgencyWales v England (16:45 GMT)
Wayne Pivac
Former Wales head coach on BBC One
If you look at the first two matches, Wales have probably been their own worst enemy.
Wales v England (16:45 GMT)
England coach Steve Borthwick says he sympathises with what the Wales players have been through this week.
The sympathy will run out by 16:45 GMT.
Wales v England (16:45 GMT)
It's been a tough old week for Wales captain Ken Owens - seemingly stuck in the middle of rugby bosses and the players.
Warren Gatland said to him on Thursday that he looked 10 years younger after an agreement was finally reached over the contracts.
Owens spoke to the press with Nigel Walker and praised his player's professionalism during a chaotic week.
Read more: Time to address 'laughing stock' image
Welsh Rugby Union chief executive Nigel Walker and Wales captain Ken Owens face the press after a day of emergency talks on Wednesday
Wales v England (16:45 GMT)
Image source, Huw Evans Picture AgencyThis is a pivotal game for both teams.
Heavy defeats by Ireland and Scotland showed not even Warren Gatland could singlehandedly pull Wales out of the mire.
They find themselves bottom of table and staring down the barrel of another wooden spoon.
Steve Borthwick's England are in slightly better shape in third.
They stuttered against Scotland before victory over Italy.
Read more: Wounded Wales get ready to face England
Wales v England (16:45 GMT)
Image source, Getty ImagesAnthony Watson's last England start came against Ireland in March 2021
Anthony Watson gets his first England start in almost two years.
He comes in on the wing for the injured Ollie Hassell-Collins in the only change to the starting XV that beat Italy in round two.
Vice-captain Courtney Lawes is set for his first England appearance since July having been named on the bench.
He's back after a string of injuries, including concussion.
Ben Curry is also a replacement after being called into the squad when brother Tom was injured.
The captain Owen Farrell once again starts at fly-half, with Marcus Smith poised to make an impact from the bench.
England: Steward; Malins, Slade, Lawrence, Watson; Farrell (capt), Van Poortvliet; Genge, George, Sinckler; Itoje, Chessum; Ludlam, Willis, Dombrandt.
Replacements:Walker, M Vunipola, Cole, Lawes, B Curry, Mitchell, M Smith, Arundell.
Wales v England (16:45 GMT)
Image source, Huw Evans Picture AgencyMason Grady is the half-brother of ex-Wales centre Cory Allen
What a stage for Mason Grady to make his international debut for Wales.
The young Cardiff centre has only made 20 regional appearances, but at 6ft 5ins and more than 17st, he certainly fits the bill for Test rugby.
He's one of nine changes made by Warren Gatland from the defeat to Scotland.
Owen Williams make his first Test start at number 10, with Dan Biggar dropping to the bench.
Joe Hawkins joins Grady in a new-look midfield, while there's an old head returning in Leigh Halfpenny, with Louis Rees-Zammit also back from injury.
The old guard of Taulupe Faletau, Justin Tipuric and Alun Wyn Jones are back in the pack.
Liam Williams and George North will be watching from home after being left out altogether.
Wales: Halfpenny; Adams, Grady, Hawkins, Rees-Zammit; O Williams, T Williams; G Thomas, Owens (capt), Francis, Beard, AW Jones, Tshiunza, Tipuric, Faletau.
Replacements:Roberts, Carre, Lewis, Jenkins, Reffell, Hardy, Biggar, Tompkins
Wales v England (16:45 GMT)
We weren't sure if we'd get here, but one of the biggest games on the international rugby calendar is just an hour away.
Wales take on England in the week they threatened strike action amid a long-running dispute over contracts.
Preparations have been less than ideal for the hosts, with training disrupted and players spending their down time locked in talks with Welsh rugby bosses.
But an agreement was reached at the eleventh hour, so we have a game on our hands.
Whether the chaotic build-up affects Wales remains to be seen, but with the old enemy in town, motivation is never in short supply.
Let's start by taking a look at the teams.
Image source, Huw Evans Picture Agency