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LIVE: Serena Williams loses 7-5 6-7 (4-7) 6-1 to Ajla Tomljanovic in US Open third round
Defeat is last match of 23-time Grand Slam single champion's career
Andy Murray loses 6-4 6-4 6-7 (1-7) 6-3 to Matteo Berrettini
Jack Draper retires injured in third set against Karen Khachanov
Top seeds Joe Salisbury & Rajeev Ram reach men's doubles third round but Jamie Murray & Bruno Soares lose
Day five of final Grand Slam of year at Flushing Meadows
We're going to take a breather but we'll be back at 00:00 BST, when Serena Williams continues her remarkable New York run.
You can also keep an eye on the rest of today's matches with the live scores.
The tennis team will be on air until 22:00 BST and you can listen using the player at the top of this page.
In a bit.
David Law
Commentator on BBC Radio 5 Live
This guy is going to reach those heights. He's going to be contending at the sharp ends of Grand Slams in the future if he is physically able to cope.
Louise Pleming
Former professional tennis player at Flushing Meadows
There's so much upside and excitement about this young man.
In my mind, he was headed for the fourth round, there's no doubt about it.
He's an exciting player, another leftie coming out of Britain. It's phenomenal.
Khachanov 6-3 4-6 6-5 Draper
Either Pablo Carreno Busta or Alex De Minaur await Karen Khachanov in the next round.
*Khachanov 6-3 4-6 6-5 Draper
Such a shame for Jack Draper, who led the third set 5-2 before the injury seemed to really kick in.
Khachanov 6-3 4-6 6-5 Draper
Jack Draper hobbles over and shakes hands with Karen Khachanov, who has some warm words for him.
The Grandstand crowd rise to applaud a visibly gutted Draper from the court.
*Khachanov 6-3 4-6 6-5 Draper
Jack Draper covers his mouth and shakes his head.
Cruel.
*Khachanov 6-3 4-6 6-5 Draper
The trainer comes out for a chat with Draper, who looks crestfallen.
His right hamstring is heavily taped.
*Khachanov 6-3 4-6 6-5 Draper
Three double faults in the game, and Jack Draper, head bowed, heads to his chair.
He looks gutted.
Louise Pleming
Former professional tennis player at Flushing Meadows
There's no vertical push at all on his serve. He's barely getting any lift off the ground.
Certainly he's in pain.
Khachanov 6-3 4-6 5-5 Draper*
Jack Draper buries a second serve into the net to go 0-30 down, before finally getting on the board with some nice work at the net.
Another double fault, though, hands Khachanov two more break points.
Murray/Soares 6-7 (2-7) 6-7 (6-8) Nys/Zielinski
Image source, Getty ImagesIt's been a bitterly disappointing few minutes for the Murray family - around the time Andy was losing to Matteo Berrettini, Jamie was exiting the men's doubles alongside Bruno Soares.
He and Soares - the 2016 champions at Flushing Meadows - lost 6-7 (2-7) 6-7 (6-8) to Monaco's Hugo Nys and Poland's Jan Zielinski.
Murray and Soares, the 10th seeds, held set points at 5-4 in the second but could not convert.
There was better news for Briton Neal Skupski and American Desirae Krawczyk in the mixed doubles, as they saw off Americans Chris Eubanks and Alycia Parks 7-6 (7-4) 6-2.
Khachanov 6-3 4-6 5-5 Draper*
Jack Draper is just trying to blast everything away to keep the points short, but it's an easy, swift, love hold for Karen Khachanov and the pressure is right back on the Brit to serve.
*Khachanov 6-3 4-6 4-5 Draper
Jack Draper asks the umpire if he can see the trainer again, which he won't be able to do until the next changeover.
Louise Pleming
Former professional tennis player at Flushing Meadows
Jack Draper's body is just not allowing him to move the way he needs to here.
*Khachanov 6-3 4-6 4-5 Draper
Jack Draper double faults!
He's feeling that injury now, whatever it is, and he mouths something to his box as he sits down.
Khachanov 6-3 4-6 3-5 Draper*
Trouble...
A long slap of a forehand and a miss at the net from Draper and it's two break points to Khachanov...
Khachanov 6-3 4-6 3-5 Draper*
Jack Draper gets the first point as Karen Khachanov slices a backhand over the tramlines, before the 27th seed fires a shot beyond an advancing Draper.
15-15.
Khachanov 6-3 4-6 3-5 Draper*
Can Karen Khachanovask the question of Jack Draper?
An ace helps him to 40-15 and a long forehand from Draper wraps up a hold.
Draper will have to serve this set out.
Louise Pleming
Former professional tennis player at Flushing Meadows
Jack Draper has worked so hard to be here.
I think this young man has done incredibly well with the path he has taken to be here and to be such a great young tennis player, he just shows so much maturity.
I love so much about his game.