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LIVE: Serena Williams loses 7-5 6-7 (4-7) 6-1 to Ajla Tomljanovic in US Open third round
Defeat is last match of 23-time Grand Slam single champion's career
Andy Murray loses 6-4 6-4 6-7 (1-7) 6-3 to Matteo Berrettini
Jack Draper retires injured in third set against Karen Khachanov
Top seeds Joe Salisbury & Rajeev Ram reach men's doubles third round but Jamie Murray & Bruno Soares lose
Day five of final Grand Slam of year at Flushing Meadows
*Khachanov 6-3 4-6 2-5 Draper
A massive ace springs the Grandstand crowd into life...
...And a second serve is sent long by Khachanov!
What a good game that was from Draper. He's a game away from a two set lead, despite visibly struggling with his movement.
Khachanov 6-3 4-6 2-4 Draper*
And some lovely touch from Draper saves it, despite a bit of a dodgy drop shot.
Khachanov 6-3 4-6 2-4 Draper*
Another chance for Khachanov as Draper goes long on a backhand.
Khachanov 6-3 4-6 2-4 Draper*
Ace out wide!
Lovely. Deuce.
Khachanov 6-3 4-6 2-4 Draper*
A serve and volley saves one, but it's still 30-40...
Khachanov 6-3 4-6 2-4 Draper*
It's not particularly smooth from Jack Draper as he's sent all around the court by Karen Khachanov, and the 27th seed sends a huge forehand whizzing past him for 15-30.
A backhand goes over the line from Draper and it hands Khachanov two break back points...
Khachanov 6-3 4-6 2-4 Draper*
Oh!
A beauty of a passing shot by Jack Draper and he leads by a break once again!
*Khachanov 6-3 4-6 2-3 Draper
Jack Draper isn't moving with the most fluidity in the world as he lets a 0-30 lead slip after pulling up on a forehand.
Still, he's going to have a chance to go a break up once again as Khachanov nets...
Murray 4-6 4-6 7-6 (7-1) 3-6 Berrettini
Matteo Berrettini speaking after his third-round win over Andy Murray:
On losing the third set: "I wasn't aggressive enough on the break points, I think Andy played a really good set.
"I thought I was going to have my chances in the fourth set and I took them."
On facing Alejandro Davidovich Fokina in the fourth round: "We have played just once and I lost, so I'm really looking forward for revenge in a way.
"He's a great player. It's going to be a tough match but I'm ready for the fight."
*Khachanov 6-3 4-6 2-3 Draper
Jack Draper is back out on court.
*Khachanov 6-3 4-6 2-3 Draper
A scrappy game from Jack Draper, who looks to be feeling a bit of the physicality in his legs, and Karen Khachanov has three break back points...
All three go begging but there's no stopping the fourth and, after squandrring the break, Draper calls for the physio and heads off for a medical timeout.
Naomi Broady
British player on BBC Radio 5 Sports Extra
A very tough loss for Andy Murray. I thought what a brilliant fightback from him, I hope he just enjoyed the emotions out there.
For me that's why you don't step away from the sport unless you absolutely have to. You cannot find those same emotions anywhere else than on a tennis court. The adrenaline, the highs, the lows - it's just not the same.
Murray 4-6 4-6 7-6 (7-1) 3-6 Berrettini
Matteo Berrettini has a long rant at the chair umpire at the end of the match. What's his beef?
The automated line calls? The length of Andy Murray's bathroom breaks?
Neither.
The Italian is peeved with the amount of time it takes for the New York public to get seated at the start of each service game. He's right as well. Give the ushers some cattle prods or something.
Murray 4-6 4-6 7-6 (7-1) 3-6 Berrettini
Matteo Berrettini wins it with his strongest stroke.
The Italian whacks down a massive ace to seal the deal and the demise of Andy Murray after a hugely promising US Open campaign.
Murray was moving well and relishing the fight. There is still plenty of fight in the old dog yet.
Murray 4-6 4-6 7-6 (7-1) 3-5 Berrettini*
Matteo Berrettini's first serve at 15-15 is about four foot wide of the service box.
But Andy Murray cannot make another of the second server, clumping into the net.
Berrettini to the net and wins the rally. 40-15.
Two match points.
Khachanov 6-3 4-6 1-3 Draper*
Karen Khachanov is even less impressed as his forehand completely goes walkabout, gifting Jack Draper a break point that a huge ace out wide saves.
He finds enough angle on one forehand, though, to keep Draper at bay and keep it to just one break of serve.
Naomi Broady
British player on BBC Radio 5 Sports Extra
It's a big ask for Andy Murray to come back, but he's done it already from a break down.
We've seen how he can neutralise some of these big serves from Berrettini.
Murray 4-6 4-6 7-6 (7-1) 3-5 Berrettini*
An unforced error from Andy Murray and suddenly he is scrapping for his existence in the draw once more....
Can he tease those Berrettini nerves once more.
*Murray 4-6 4-6 7-6 (7-1) 3-4 Berrettini
Andy Murray's stretching volley dies in the net.
Matteo Berrettini has two break points. If he takes either, he serves for the match next...
*Murray 4-6 4-6 7-6 (7-1) 3-4 Berrettini
Matteo Berrettini gets himself safely to shore after negotiating some choppy waters.
The Italian has the prospect of a come-from-behind defeat looming in his rear-view mirror. Can he keep his eyes on the road to steer this home?