Some glorious serving from Karen Khachanov, backed up with some massive forehands, help him whizz through his latest service game.

Jack Draper's first serve has not quite clicked into place yet and he finds himself at deuce, before another huge Khachanov forehand brings up break point...

...Saved with a one-two punch! On we go.

Well, well, well. Matteo Berrettini drifts a horrible backhand slice into the top of the net.

Murray off the hook. For now. Deuce...

Matteo Berrettini's block backhand is low and hard enough to give Andy Murray issues coming into the net.

The Briton's volley is into the net and he is 0-30 adrift.

Murray cuffs a forehand long and wide with a huge slice of unoccupied court to aim at.

30-40 and break point Berrettini...

Naomi Broady
British player on BBC Radio 5 Sports Extra

I'm not surprised Berrettini's box are pleased with that last service game.

Andy was throwing everything but the kitchen sink at him trying to get all the balls back in play, but Berrettini was just steamrolling with that forehand.

More Brits in doubles action now - Jamie Murray and Brazilian partner Bruno Soares are in the early stages of their men's doubles second-round match against Monaco's Hugo Nys and Poland's Jan Zielinski. Murray and Soares trail 2-1 on serve in the first set.

In the first round of the mixed, Neal Skupski and American Desirae Krawczyk are playing Americans Chris Eubanks and Alycia Parks - and it's also 2-1 on serve to Eubanks and Parks.

You have got to be pretty sure of yourself to continue your conversation with a fellow spectator after the umpire announces over the tannoy that the players are waiting for you and Matteo Berrettini shoots daggers at your back from the court floor.

Guess that is the New York chutzpah they like to bang on about...

Anyway, the bearded fellow in the pork pie hat finally feels ready to settle into his seat and Berrettini takes out his frustration on the fuzz, whacking his way through a service game to love.

Naomi Broady
British player on BBC Radio 5 Sports Extra

There was a lot going on there, to try and keep his focus, his shoulder was cold after that long break.

He's done well to dig himself out of that hole, has Murray.

Comeback complete!

Andy Murray digs his way out of the darkness to save the game from 15-40 down for a second successive time.

How long can he keep pulling off such heroics though?

The third set remains on serve.

Jack Draper is on the board.

A pair of massive forehands put him on the front foot and he wraps up a hold to 15 with a huge ace down the T.

He's still down by a break, mind, but he's stopped Karen Khachanov from racing away with the opening set.

The spectator is up on their feet and Andy Murray duly continues his own recovery, saving another break point to move to deuce.

Jonathan Jurejko
BBC Sport at Flushing Meadows

Serving from that end of Ashe where Murray is now, sunbeams streaming into his face, is as difficult around this time as it can be all day.

Murray is already struggling on his first serve as it is.

He has landed just 30 of his 65 first serves.

Andy Murray saves the first break point to claw his way back to 30-40 against Matteo Berrettini.

But his rescue operation has been stalled by a medical issue in the crowd. Play has been held up while medical staff treat someone in the stands.

Andy Murray made a good escape from 15-40 down on his last service game. The bad news is he is right back in the same pickle now....

Berrettini probing away at the Murray tee-off once more...

A slightly sticky start for Jack Draper.

He had worked his way to 40-15 but a fluffed drop shot and a double fault meant he found himself at deuce.

He had game point but a pair of forehand errors handed Karen Khachanov a break point, and a snatched shot into the net tape gifts the early initiative to the 27th seed.

Matteo Berrettini is just out here slam-dunking and sky-hooking like Kareem Abdul Jabbar.

The Italian is all overhead as he wallops down a big serve and slaps away the smash to hold to 15 in silky smooth style.

Jonathan Jurejko
BBC Sport at Flushing Meadows

Before his opening match here, Andy Murray was asked to reminisce about his 2012 triumph.

The Scot recalled his feelings before and after finally landing what had been an elusive major title.

"It was obviously, at the time, a huge moment for me. I’d been put under a lot of pressure to try and achieve that," he said.

"A lot of what I’d achieved in my career up to that point it felt, to me anyway, kind of irrelevant because of the questions I’d continued to get asked about winning Slams. Am I good enough? Am I fit enough? Am I mentally strong enough? Like lots and lots of questions over a period of time.

"It was nice to finally be able to move on from that because it’s not particularly helpful."

Fire up that Undertaker GIF.

Andy Murray climbs off the canvas, recovering from 15-40 down to salvage the first game of the third set.

It might have been curtains for his US Open campaign if he hadn't, considering how Matteo Berrettini is serving at the other end.

Karen Khachanov will serve first to get his match against Jack Draper under way.

* denotes next server

Naomi Broady
British player on BBC Radio 5 Sports Extra

Murray needs to up his first-serve percentage just to keep Matteo Berrettini neutralised. Apart from that, he hasn't done a lot wrong.

Andy Murray's body language is saying a lot. And none of it is pretty.

The first serves are still sliding around. And a wayward forehand offers up two break points at 15-40 to Matteo Berrettini.