What's happened so far in early games?published at 20:25 BST 21 September
At half-time the Los Angeles Rams were firmly in charge at the Philadelphia Eagles but the Super Bowl champions are fighting back.
The Indianapolis Colts have been this season's surprise package so far and they are turning on the style again as they look set to join the Buffalo Bills on 3-0.
The Green Bay Packers are leading a low-scoring game at Cleveland, while their former quarterback Aaron Rodgers has reached another landmark with Pittsburgh, who are currently level with New England.
We wondered how the Cincinnati Bengals would manage after star quarterback Joe Burrow's injury and although they are being well beaten at Minnesota, it's the Bengals' offensive weapons that are letting them down, not back-up QB Jake Browning.