Team news
Manchester United wing-back Patrick Dorgu serves the second game of a three-match domestic ban following his red card in the win over Ipswich.
Harry Maguire and Manuel Ugarte are both doubtful after missing the midweek draw with Real Sociedad.
Teenager Chido Obi could feature after being ineligible for Thursday's European game.
Arsenal's Myles Lewis-Skelly is available again after suspension ruled him out of the the Gunners' most recent Premier League match against Nottingham Forest.
Bukayo Saka, Gabriel Martinelli, Gabriel Jesus, Kai Havertz and Takehiro Tomiyasu remain sidelined.
Match facts
Head to head
Manchester United have lost their last four Premier League games against Arsenal, the longest losing run against the Gunners in their league history.
However, United came out on top in the most recent meeting, winning on penalties in the FA Cup third round in January.
Arsenal could win consecutive away league games against Manchester United for the first time since February 1979.
The Gunners have scored in each of their last 10 Premier League matches at Old Trafford, netting 13 times in total.
Manchester United
Manchester United are yet to win consecutive league games this season - it's their longest wait for back-to-back league victories in a single campaign since 1968-69, when they won their 32nd and 33rd games.
United have lost four of their last six home league matches, failing to score in three of those defeats.
They have conceded 24 Premier League goals in matches at Old Trafford this season, as opposed to 15 in league games away from home.
The Red Devils have conceded the opening goal in 12 different Premier League fixtures since Ruben Amorim's first game, second only to Leicester City in that period.
Rasmus Hojlund has not scored in any of his last 19 appearances in all competitions.
Arsenal
Arsenal are unbeaten in their last nine away league matches (W5, D4), and have not conceded in any of their last three.
However, they have failed to score in their last two Premier League games, managing just three shots on target across those matches.
Arsenal have conceded 23 goals in the top flight this season, fewer than any other side.
They have drawn nine of their 27 league games this season, their most since 2019-20.
Mikel Arteta has won seven of his 10 Premier League games as a manager against Manchester United (D1, L2).
This will be Arteta's 200th Premier League game in charge of Arsenal. He's won 118 of his first 199, the fifth-most of any manager in their first 200 (behind Pep Guardiola, Jose Mourinho, Jurgen Klopp and Sir Alex Ferguson).
