Southampton were looking to start the new year on a positive note. Instead, this was utterly bleak for Saints.
The home fans who left after Mbeumo made it 3-0 departed in full confidence they would not be missing a fightback from their side.
There has been no 'new manager bounce' under Ivan Juric who has become the seventh Southampton boss to lose his opening three league games in charge.
Southampton have fewer points at this stage than Derby did in 2007-08 when they went on to set a Premier League record low for a season of 11 points.
Juric said after Saturday's game: "There was such a difference between the two teams and I'm disappointed with everything: the team, myself, everybody.
"Today I was thinking about one step forward and we took three steps back. It was a really bad performance.
"We cannot lose 5-0 at home. I feel responsible, sorry. The game, it was awful. This day cannot happen any more."
From Southampton's only real chance, a header from Paul Onuachu was easily saved by Brentford goalkeeper Mark Flekken.
This was the third league game since early December in which Southampton have conceded five goals at home, with Chelsea and Tottenham both rampant at St Mary's last month.
A combination of dreadful defending and low confidence from Southampton allowed Brentford to follow their fellow London sides in trampling over the home side.
Relegation feels inevitable, with Southampton's six points from their opening 20 games matching Sunderland's class of 2005-06 for the worst tally by a side at this stage in the Premier League era.