Team news
Arsenal forward Gabriel Jesus will have an operation on his left knee after sustaining an anterior cruciate ligament injury during Sunday's FA Cup tie against Manchester United.
Riccardo Calafiori is a doubt because of the muscular injury that caused him to miss that match, while Ethan Nwaneri, Bukayo Saka, Takehiro Tomiyasu and Ben White remain out.
Tottenham forward Timo Werner is expected to miss Wednesday's derby with the hamstring injury he suffered against Tamworth.
Goalkeeper Fraser Forster could be available after illness but Antonin Kinsky may retain his place after clean sheets in his first two games for the club.
Match facts
Head-to-head
Arsenal have won six of their last eight league games against Tottenham (D1, L1).
They could win three consecutive top-flight north London derbies for the first time since a run of five from 1987 to 1989.
Spurs have won just two of their 32 Premier League away fixtures against Arsenal (D12, L18), and none of the last 13 since a 3-2 victory in November 2010.
Arsenal are looking to complete a Premier League double over Tottenham for the fifth time.
Spurs haven't kept a clean sheet in 25 away league games against the Gunners since a 0-0 draw in November 1998 when Espen Baardsen was in goal for the visitors.
Arsenal
Arsenal are unbeaten in their past 12 league matches at the Emirates (W9, D3) and are the only side yet to lose at home in the top flight this season.
They are aiming to keep a clean sheet in five straight home league games for the first time since December 2013 to February 2014.
The Gunners have conceded a league-high 28% of their goals in the opening 15 minutes of games this season (five of 18). Tottenham have scored 11 goals in this time period, more than any other side.
Mikel Arteta's side have had a greater expected goals total than their opponent in 25 of their 30 matches in all competitions this season, including 18 of the last 19.
Martin Odegaard created 10 chances in their FA Cup tie with Manchester United, the highest tally in a game by a Premier League player across all competitions this season.
Tottenham Hotspur
Tottenham's only win in their past eight league matches was 5-0 at bottom side Southampton (D2, L5). Since the start of December, only Leicester and Southampton have earned fewer points than the five by Spurs.
They have kept back-to-back clean sheets in all competitions for only the second time this season.
Spurs have 15 fewer points than at this stage last season, despite scoring the same number of goals and conceding just one more.
Their run of 101 top-flight games without a 0-0 draw is the second longest in Premier League history after Manchester United's 114 between May 1999 and May 2002.
Only Erling Haaland, with 14, has scored the opening goal in more top-flight appearances than Dominic Solanke's 11 since the start of last season.
Dejan Kulusevski's tally of eight goals in all competitions is the same as he managed across the whole of last season.
