Team news
Tottenham forward Wilson Odobert has been ruled out with the hamstring injury he sustained against Coventry on Wednesday.
Timo Werner is available and Yves Bissouma should return, but Richarlison remains on the sidelines.
Brentford's Yoane Wissa will be out for a couple of months due to the ankle issue he sustained against Manchester City.
Head coach Thomas Frank is still without Josh Dasilva, Aaron Hickey, Mathias Jensen, Gustavo Nunes and Igor Thiago.
Match facts
Head-to-head
Brentford have won only three of their 22 matches against Tottenham in all competitions.
Their solitary away win at Spurs was 3-1 in May 2023.
The team scoring first has failed to win in any of the last four league meetings (D2, L2).
Tottenham Hotspur
Tottenham’s tally of four points after four league matches is their lowest since the 2015-16 campaign.
Spurs are looking to avoid losing three of their opening five league games for the first time since the 2008-09 season under Juande Ramos.
They have lost seven of their past 11 top-flight matches, only earning points in that run against relegated pair Burnley and Sheffield United, promoted Leicester City and bottom of the table Everton.
Spurs are the only team to have had at least 60% possession in all four of their top-flight matches this season.
Tottenham have conceded 26 set-piece goals in the Premier League since the start of last season, second only to Nottingham Forest's 27.
They have drawn only one of their last 50 league home matches, and none of the last 23.
Spurs are looking to avoid equalling their longest home losing streak in Premier League London derbies: three from August 2003 to April 2004.
Brentford
Brentford have lost 12 of their past 16 away league games.
They could lose their opening three away matches of a league campaign for the first time since 2004-05 in League One.
Thomas Frank’s side have lost four consecutive Premier League away derbies, after they were beaten in only three of their first 13.
The now-injured Yoane Wissa has been directly involved in eight of their last 10 league goals, with five goals and three assists.
Each of their past seven top-flight goals have been scored by either Wissa (four) or Bryan Mbeumo (three).
Mark Flekken has made 22 saves in four top-flight matches this season, six more than any other goalkeeper and the second highest tally at this stage of a Premier League season after Tim Krul's 23 for Newcastle in 2003-04.
