Southampton

Southampton boss Russell Martin confirmed that his players have "pretty much recovered" from the illness which was sweeping through the club.

He added that Ryan Fraser is the only doubt for this weekend, after coming off early in the Carabao Cup win against Stoke City: "We will have to assess him again in the morning. He trained a little bit today, but we will have to see if he is available."

Manchester City

On having the option to play academy players, Pep Guardiola said: "We use them because we are in an emergency in certain positions, but we trust them to help us and that is why the academy is there."

In response to whether a conversation needs to be had about the football calendar: "We know it [is too many games] but it is the reality. We try to take care of them. We’ve not done anything differently to previous seasons. If anything we’ve trained less, but it happens and you have to adapt."

Aston Villa

Aston Villa boss Unai Emery on Manchester United's new manager Ruben Amorim: "I do not think the sacking of [Erik] ten Hag is a good thing, but this is football.

"Amorim, I know about him. He is doing very good work in Portugal with Sporting Lisbon and if Manchester United decided to hire him, it's because he deserves it."

Aston Villa

Aston Villa boss Unai Emery on his team's busy and important week ahead: "My focus is on the next match and I am thinking only about this.

"Sometimes I am planning for the weeks coming or months, but I want to learn with experiences. I tell my players to try to be focused on the next match. It is about which players are the best to play the match against Tottenham. For me, the focus is on the match against Tottenham.

"Every match we are playing, we are trying to identify our corrections, our mistakes, our process, and we are analysing how we are now and how are they, with the players they have."

Manchester City

On whether they will have to look at buying players as injury replacements in January, Pep Guardiola said: "Maybe in January we will have all the players back, except Rodri. When we are all together, the squad is enough, when completely focused and fit. For now we just have to try to recover players as quick as possible and then we will see."

Manchester City

Manchester City boss Pep Guardiola started his news conference by saying thatwinger Savinho could be available having suffered "no fracture" with the "strong knock" he picked up against Tottenham, but Guardiola does not know who else will recover in time for the game.

"Tomorrow you will see [who is available], I have many doubts, half and half," he said. "It happens in many clubs and we’re not the only club in the world to be going through it. There are a lot [of injuries] in certain departments and positions but it is what it is.

"I've said to the players 'don’t feel sorry for ourselves, our challenge is this' and we will play with 11 players tomorrow. I will talk to players to see how they feel and the doctors. It is just day by day."

Simon Stone
BBC Sport's chief football news reporter

I am not sure too many have sympathy with Manchester City boss Pep Guardiola over his claim he only has 13 fit outfield players.

City are top of the Premier League and in the top eight of the Champions League, so it is not as though they are in distress.

But Guardiola is having to navigate his way through a difficult situation, with tricky away games against Bournemouth and Brighton, plus a Champions League meeting with Sporting and new Manchester United boss Ruben Amorim to come in the next week.

We shall hear his thoughts shortly.

Aston Villa

Aston Villa manager Unai Emery was asked about the floods that occurred in his native Spain this week, which have now claimed more than 200 lives:"I want to send my condolences. We had a tragedy in Valencia, I am very sad.

"All my condolences for the people affected and to the families of the victims. Hopefully they can recover again quick with everything that happened there."

Aston Villa

Now here's the manager Ange Postecoglou is up against this Sunday, Aston Villa boss Unai Emery: "We had only one injured player and it’s Ross Barkley. He has a small injury, but he’s not going to be available for the next two weeks."

Tottenham Hotspur

Here's a final word from Tottenham manager Ange Postecoglou, on whether fans can expect ups and downs in results: "I keep saying, fans are fans. There isn’t a fan around the world who doesn't want their team to always be playing well.

"What we have to do before the game and after the game is stay really focused on continuing to evolve into the team we want to be. At the moment in the league we have had some disappointing results, but only really one disappointing performance with the Palace game.

"It wasn’t a great performance and we got what we deserved. What we have to focus on is we continue to learn from that. When we have had disappointments we have bounced back straight away which I think is really important and part of the evolution.

"It’s not going to be a smooth ride but we knew that. We don’t want to have too many times when we’re not playing the football we want to. That is always the benchmark for us and our measure, and Wednesday night was a lot better [against Manchester City]."

Jamie Carragher
Former Liverpool defender on Sky Sports

It’s a big job for Ruben Amorim. Manchester United are 14th but that’s a quick fix because Manchester United shouldn’t be 14th. They’ve got a squad that’s just outside the Champions League places, competing with Tottenham, Aston Villa and Chelsea. They’re not too far away.

Making that step is difficult. In terms of getting over the line, that’s the toughest. [Ole] Solskjaer finished second, [Jose] Mourinho finished second, [Erik] Ten Hag finished third - that’s not too hard for Amorim to get to, it is the next step after that.

This is how freelance football writer Alex Keble suggests Manchester United could line up under Ruben Amorim, although he does caveat this by saying that Bruno Fernandes could be swapped with Kobbie Mainoo to get United's club captain into the starting XI.

Image source, BBC Sport

Chelsea

Finally from Enzo Maresca, here's the Chelsea boss on finding balance in his midfield: "It's a matter of balance. Romeo [Lavia] and Moises [Caicedo] give us physicality, strength in the middle. This is why we found the option of Malo [Gusto] in the pocket.

"When we play with Enzo [Fernandez], it has to be Enzo and one between Moi and Romeo. When Enzo moves we struggle in the middle with physicality. In this moment, Moi and Romeo give us this.

"This [lack of physicality] doesn't mean that we can't play with Joao [Felix] and Cole [Palmer] in the pocket. Soon, we are going to see Joao [Felix] and Cole [Palmer] together in the pocket. It's always the game that requires [something] a little bit different."

Chelsea

Chelsea boss Enzo Maresca on his side's recent success from counter-attacks: "It's not for me whether we need to play slow or fast. Think of the Brighton game, we tried to attack quick because the space was in behind. We can't play the same game against Nottingham Forest when they sit back in their side. It depends on the game.

"We have players in wide areas that can attack quick but I've said many times, the problem when you attack quick is they attack quick, then it becomes like Newcastle, up and down. Then it's better for them than us.

"We score many goals in the second half. It happened when I was at Leicester. In the first half we touch, touch, touch - [the opposition] run, run, run.

"They can't maintain that for 90 minutes so the last half an hour they start to drop and this is the moment we create more chances and score goals."

Martin O'Neill
Former Celtic manager on BBC Radio 5 Live

I think there’s an element of doubt when you take on any manager at any given stage, whether he has got loads of experience or whether he is just an up and coming manager. That seems to be the case at the moment with Ruben Amorim.

At this moment, he’s done wonderfully well at Sporting. He hasn’t been in a big league and that is true. The bottom line is this, the time and tide don’t wait for any man and that is the case.

You have to get up and running, a bit like me at Celtic in that sense. You know you are under pressure immediately because of the size of the football club. Manchester United are demanding because of their last 20-odd years. They’ve gone with this because they think he can turn things around.

Tottenham Hotspur

Tottenham manager Ange Postecoglou on being drawn against Manchester United in the Carabao Cup: "It’s a good draw in terms of it’s a home game which, for all clubs, is welcome because you know it isn’t going to be an easy game whoever you play.

"Being at home for us against a club like United, it will be a really good fixture, but you expect that at the quarter-final or semi-final stage of a competition."

On United appointing Ruben Amorim as their new head coach: "I’ve only just heard that Ruben has been appointed so he will have his feet firmly under the desk by then and I’m looking forward to meeting him."

Alex Keble
Football tactics writer

Image source, BBC Sport

Ruben Amorim is, first and foremost, a flexible tactician.

He will sit deep when required and push high when he can; will play neat possession football in some fixtures and tell his players to hit longer diagonals out to the wide men in others.

Case in point: Sporting topped the charts in Portugal for both build-up attacks (126) and direct attacks (74) last season.

But one thing that doesn’t change is the 3-4-3 formation, which is rumoured to be a factor in why Liverpool favoured Arne Slot over Amorim when Jurgen Klopp left this summer.

That means Manchester United will revert to a back three for the first time in a decade - since the early days of Louis van Gaal in 2014.

De Ligt, the marquee summer signing, is the most likely to struggle. He didn’t look comfortable when Bayern Munich experimented with a back three under Julian Nagelsmann in 2022-23 and was dropped from Louis van Gaal’s Netherlands back three just one game into the 2022 World Cup.

Harry Maguire is the only United player used to a back three, and inexperience here is a particular concern given that Amorim’s aggressive high line leaves space out wide and in behind.

The Premier League is increasingly defined by the sort of fast transitions that could expose this vulnerability, and we saw the downsides of Amorim's approach when Manchester City tore through Sporting in a 2022 5-0 Champions League win in Lisbon.

Then again, any downsides from the switch may be countered by the basic defensive advantage of moving from a four to a five.

After all, last season United conceded the second most shots of any team in Europe’s ‘big five’ leagues (667) whereas Sporting, in a compact off-the-ball 5-4-1, conceded the fewest shots in the Primeira Liga (269).

Chelsea

Chelsea boss Enzo Maresca on striker Nicolas Jackson, who has six Premier League goals this season: "We are very happy because Nico is helping us, not just in terms of numbers but in the way we want to play. The way he links with his team-mates is helping us in our process. When he drops he gives us an extra man. When he attacks in behind, he is quick and can score goals. You saw against Newcastle when he drops, the options he gives.

"We are very happy. We try to work with him in different areas, one is when he drops but also what he has to do then. We have been trying to improve Nico since we started."

Chelsea

Chelsea boss Enzo Maresca on Argentina midfielder Enzo Fernandez, who has not started the last two Premier League matches: "I show frustration with all of them, don't look just at Enzo. I still trust Enzo, there is no reason in the world I can lose confidence in him. The reason why he is not playing in the Premier League is because I take another decision but my confidence is 100% with Enzo.

"I like to say that we don't have an A or B team. There are players that are fantastic but we don't have indispensable players. If Cole [Palmer] isn't playing, we play Joao [Felix]. If Nico [Jackson] doesn't play we play Christo [Nkunku]. There is not one we can't change.

"The reason why we change players is because they are all good. You are looking for some different reasons for Enzo but he is going to play for sure in the future. It doesn't mean Romeo [Lavia] and Moises [Caicedo] are always going to play. As soon as one of them drop, for sure we are going to change."

Ruben Amorim will be the new Manchester United manager but will not be arriving for a few weeks. In the meantime, Ruud van Nistelrooy is in charge as interim boss and he enjoyed himself against Leicester in the Carabao Cup in midweek.

The Chelsea players will be well-rested because their team that lost to Newcastle in the same competition on Wednesday was totally different to the side that beat the Magpies in the league on Sunday.

But Newcastle did create chances against them last weekend and, when I saw Chelsea against Liverpool recently, they were brave at Anfield too.

I see Chelsea as being the superior team here and my head tells me they will win, but if they are quite open again at Old Trafford then that could suit Manchester United and let them get something. Sutton's prediction: 1-1.

Brad Kella's prediction: Chelsea have got this and I'm going for a Cole Palmer hat-trick. What a mistake it was by Pep Guardiola to sell him, because he is just unbelievable. 0-3.