Team news
West Ham United full-back Aaron Wan-Bissaka, who has featured in every Premier League game for the club since making his debut in August, is expected to be available after having an injection in a toe injury earlier this week.
Crysencio Summerville is still several weeks away from returning following three months out with a hamstring problem.
Southampton midfielder Flynn Downes is available after missing the defeats against Tottenham Hotspur and Aston Villa because of suspension.
Paul Onuachu will be assessed after he was forced off at half-time against Villa due to an ankle injury.
Match facts
Head-to-head
West Ham's solitary defeat in their past 12 Premier League games against Southampton was by 3-2 at home in December 2021 (W8, D3).
Southampton's first Premier League away match against West Ham ended in a 3-3 draw in May 1994. Since then, none of their 20 top-flight visits to the Hammers have finished level (W5, L15).
West Ham United
West Ham United are 17th in the Premier League - their lowest position heading into the 33rd game of the season since 2010-11, when they ended in 20th and were relegated.
The Hammers are winless in five league matches, their longest run without a victory this season.
They have taken just 12 points from as many games under Graham Potter.
Since Potter's first Premier League fixture in charge on 14 January, only Southampton and Leicester City have attempted fewer shots than the Hammers' 114.
Only Leicester have registered fewer shots on target than West Ham's 34 during the same period.
Two of the last five goals scored by West Ham in the Premier League have been own goals by Leicester's Jannik Vestergaard and Liverpool's Andy Robertson.
Southampton
Southampton have now lost a club record 26 of their 32 matches - it is the most league defeats they've suffered across a season in any division.
Saints need one point from their remaining six games to avoid setting an outright Premier League record for the lowest tally in a season. It is currently held by Derby County, who finished with 11 points in 2007-08.
Southampton are the lowest scorers in the top four English divisions with just 23 goals.
Their current 81% loss percentage is the highest by any side in top-flight history.
Southampton have faced a league-high 225 shots on target in the Premier League this season.
They are one of only two teams on record since 2003-04 to be facing seven or more shots on target per game, along with Sheffield United last season.
On the day of the game, Southampton will have spent a club record 170 days bottom of the Premier League this season.
Across their last two seasons, they've spent 60% of their time in the Premier League in 20th spot.