Shakhtar Donetsk, Ajax and Schalke are all still leading and are through to the knockout stage as it stands.

Brazilian midfielder Fred has scored Shakhtar's fourth, while Ajax are now 3-0 up against Celta Vigo and Schalke remains 2-0 against Krasnodar.

Other second-half goals have come for Standard Liege, who lead Panathinaikos 1-0. In France Red Bull Salzburg are 1-0 up at Nice, and Azerbaijani side Qarabag lead PAOK Salonika by the same scoreline.  

Sporting Braga's match against Konyaspor is still 2-1 but both sides are now down to 10 men.

A Dusan Tadic corner fizzes just over the heads of Southampton players as the hosts go within a whisker of a chance for a third.

Some might say that was justice for Southampton after they were not awarded what appeared a clear penalty earlier in this half.

Inter Milan are having to try to repel wave after wave of pressure and Stefano Vecchi makes a change, replacing Gary Medel with Eder.

"Oh when the Saints" boom the home fans. That goal has really lifted the crowd and Southampton are straight on the hunt for a second. Charlie Austin harasses Miranda, but the defender's clearance hits the Southampton striker and goes out for a goal kick.

Simon Stone
BBC Sport at St Mary's Stadium

I grew up with a stereotypical image of an Italian team.

Niggly, argumentative, playing on the edge.

It's unfair of course. There have been some great Italian sides down the years and the current Juventus side are among the best around.

But given their well-documented problems, Inter are reverting to type. They are going to try and protect this lead with every trick they have at their disposal.

Here is the moment that marred the end of the first half. Antonio Candreva strikes Sam McQueen in the face. It certainly looked like it should have been a red card. 

Image source, Reuters

A touch over 30 minutes remaining and Claude Puel decides his attack needs a bit more bite. Charlie Austin is on for Jay Rodriguez.

Should Southampton have a penalty?

Virgil van Dijk appears to be wrestled to the floor by Andrea Ranocchia. 

It certainly looks like a penalty, but the referee isn't convinced.

Southampton have some defending to do for the first time in this half as Ivan Perisic attempts to feed a ball to the far post for Mauro Icardi. Sam McQueen is there to clear, allowing the Saints to attack once again.

Great atmosphere at St Mary's. The home fans are certainly doing all they can to urge their side forward.

The Inter Milan fans are lucky their side are not down to 10 men. As stewards keep an eye on them, they are trying their best to make some noise but are being drowned out by the Saints faithful. This match has definitely got a bit spicy! 

Image source, Rex Features

Gary Medel catches Peirre Hojbjerg with his hand as the two challenge for possession and the Inter midfielder picks up a booking as a result.

Excellent at stopping penalties and excellent at stopping shots in general if this showing is anything to go by.

James Ward-Prowse has another pop from distance but this time his strike is much more meaty, forcing Samir Handanovic into a fine one-handed save.

It is going to take something special to beat him tonight.

Southampton have started this half well as they attack again. This time Nathan Redmond's cross is cleared to Pierre Hojbjerg on the edge of the Inter area. Hojbjerg has time but rushes his shot and balloons it over the bar.

The hosts are straight on the attack as James Ward-Prowse hits a first-time shot from the edge of the area straight at Samir Handanovic.

And we're back under way.

The players are back out on the pitch.

Looks like no changes for either side.