Who else is playing?published at 19:02 Greenwich Mean Time 16 February 2017
As ever it's a busy night across Europe with 16 ties across three kick-off times and multiple time zones.
The biggest game under way for those in the UK is Tottenham's trip to Gent.
The score is currently 0-0 and you can follow full commentary here. The second half has just begun.
In the rest of tonight's second wave, Roma face Villarreal in the pick, with both sides heavily backed to win the trophy. Behind the Premier League duo, that is.