Sergio Aguero becomes the ninth player to score 150 Premier League goals.

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Eden Hazard is back from injury but the Premier League's joint leading scorer can only make Chelsea's bench as Maurizio Sarri keeps faith with the 11 who dismantled Burnley in their last league game.

Ross Barkley has scored in each of his last three Premier League games. Only two Englishmen have scored in four in a row for Chelsea - Frank Lampard and Mark Stein.

Chelsea XI: Arrizabalaga, Azpilicueta, Rudiger, Luiz, Alonso, Kante, Jorginho, Barkley, Pedro, Morata, Willian.

Subs: Fabregas, Hazard, Loftus-Cheek, Caballero, Kovacic, Zappacosta, Cahill.

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Roy Hodgson makes one change to the Crystal Palace side that started last week's battling 2-2 draw with Arsenal.

Forward Jordan Ayew, who has yet to score this season, drops to the bench and in comes German Max Meyer.

Wilfried Zaha is chasing his first goal since 15 September.

Crystal Palace XI: Hennessey, Wan Bissaka, Tomkins, Sakho, Van Aanholt, Milivojevic, Kouyate, McArthur, Meyer, Townsend, Zaha.

Subs: Sorloth, Ayew, Schlupp, Guaita, Kelly, Puncheon, Riedewald.

David Silva is dumped to the turf by Mario Lemina. But it is James Ward-Prowse getting the booking, for kicking the ball away.

Kyle Walker is off the pitch momentarily to receive treatment on an ankle injury. When he does return he continues to move a bit gingerly. One to watch.

Image source, Reuters

Michael Brown
Former Man City midfielder on BBC Radio Manchester

You can't make this up.

The amount of pressure, they keep the ball alive.

A fantastic touch, Sane tries to be unselfish but brilliant play.

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City on the front foot straight away. Sergio Aguero drives forward, setting up Raheem Sterling for a chipped cross back into the box that is headed clear and then hammered away.

Soon after, Sterling is involved again, playing an enticing ball across the box but nowhere near a team-mate.

Kyle: From a neutrals point of view I hope City draw and Chelsea win then the top 3 sides will all have 27 points. That would be some start. That said the likelihood is City and Chelsea will both win and City will be 2 clear of Chelsea and Liverpool.

Be interesting to see how Saints approach this. Dig in from minute one or at least try to offer something going forward. The first plan strikes me as a recipe for defeat.

Danny Ings and Shane Long have a big job to play, defending from the front.

Eden Hazard is fit enough only for the bench for Chelsea, who stick with the same starting XI that hammered Burnley last time out.

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Good things come to those who wait. Game on.

As we've seen elsewhere all weekend, the Etihad comes together in a minute's silence both for Remembrance and those who lost their lives in the helicopter crash in Leicester.

As with everywhere else, it is impeccably observed.

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Simon Stone
BBC Sport at the Etihad Stadium

Manchester City full-back Benjamin Mendy has confirmed what I think we already knew in today's match programme, namely Pep Guardiola is a football obsessive.

Mendy says: "He leaves and breathes football. He is always thinking and figuiring things out.

"He talks football, football, football. It is impossible not to tap into that passion and enthusiasm."

Man City: Ederson, Walker, Stones, Laporte, Mendy, Bernardo Silva, Fernandinho, Silva, Sterling, Aguero, Sane.

Subs: Danilo, Kompany, Delph, Mahrez, Gabriel Jesus, Foden, Muric.

Southampton: McCarthy, Cedric, Stephens, Hoedt, Bertrand, Redmond, Ward-Prowse, Hojbjerg, Lemina, Long, Ings.

Subs: Yoshida, Vestergaard, Austin, Elyounoussi, Armstrong, Gunn, Obafemi.

Here come the teams at the Etihad. And here is a reminder of them...

Image source, BBC Sport

Saints kept a clean sheet against Newcastle and Bournemouth in their past two games, but stopping City's attack is something else entirely. I cannot see it happening.

Prediction: 3-0

Lawro's full predictions v rock band Bring Me The Horizon

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Abandon hope all ye who enter.

Manchester City have won seven of their last nine Premier League meetings with Southampton, drawing one and losing one with an aggregate scoreline of 22-9. That's 22-9.

Saints are winless in their last eight visits in all competitions at the Etihad Stadium, drawing one and losing seven.

Saying that, last time they met at the Etihad, it took a 96th-minute winner from Raheem Sterling to settle the game.

Conor McNamara
BBC Radio 5 live commentator at Etihad Stadium

Two coaches with much in common, having played for Barcelona and managed Manchester City, but current objectives for Pep Guardiola and Mark Hughes are very different.

By this stage last year City already held a five-point lead at the top, this season there is a more robust title race for Guardiola to deal with.

Meanwhile, Southampton are just two points above the relegation zone and are in danger of setting a new club record of six games in a row without scoring.

Saints have only delivered six league goals in total this season. Sergio Aguero has scored that many by himself.

Manchester City manager Pep Guardiola:"I am impressed with the quality Southampton have in the middle and at the front.

"They have huge talent and are so deep and so physical. It is so complicated to beat them. We must be sharp and move well and be clever. It will be a tough game."

Southampton manager Mark Hughes:"There are always elements of any team that you can look to exploit, no matter how good they are.

"They [Manchester City] get into winning positions very quickly which we can't let happen. They are going to have a lot of possession and we need to be patient and know when to press and when we can't press."