Ben White slides in Gabriel Jesus but Eric Dier does well to get a toe in and Hugo Lloris can gather it in.

Bournemouth make one change from the side that earned a draw in their last outing against Newcastle.

Kieffer Moore will lead the line as he replaces Ryan Christie in the starting XI.

Bournemouth: Neto, A Smith, Mepham, Senesi, Zemura, L Cook, Lerma, Tavernier, Billing, Moore, Solanke

Subs: Travers, Stephens, Christie, Marcondes, Stacey, Lowe, Dembele, Hill, Anthony

Visitors Brentford make two changes from the side that were well beaten by Arsenal last time around.

Mikkel Damsgaard will make his first Premier League start in place of Josh Dasilva, while Shandon Baptiste replaces Aaron Hickey.

Brentford: Raya, Ajer, Jansson, Mee, Baptiste, Damsgaard, Janelt, Jensen, Henry, Mbeumo, Toney

Subs: Cox, Buchanan, Hickey, Dasilva, Wissa, Zanka, Ghoddos, Onyeka, Roerslev, Trevitt

Oliver Skipp is on for Pierre-Emile Højbjerg now too. All of those changes has undoubtedly killed the game a little but Arsenal look on course to claim three big points unless Tottenham can drastically turn things around with 10 men.

Gary Rose
BBC Sport at Anfield

Jordan Henderson returns to the Liverpool starting XI after recovering from injury.

The midfielder missed the last few games before the international break with a hamstring injury.

Henderson's return is one of three changes from the win against Ajax in the Champions League last time out as Fabio Carvalho and Roberto Firmino also start. Darwin Nunez, Luis Diaz and Diogo Jota are on the bench.

Liverpool XI: Alisson, Alexander-Arnold, Matip, van Dijk, Tsimikas, Henderson, Fabinho, Thiago, Salah, Firmino, Carvalho.

Subs: Gomez, Milner, Adrian, Elliott, Jota, Diaz, Nunez, Arthur, Phillips.

Image source, .

New Brighton boss Roberto de Zerbi makes just one change from Graham Potter's final starting XI from the 5-2 win against Leicester at the start of September.

Pervis Estupinan is the only player to come into the side. Former Liverpool midfielder Adam Lallana is on the bench.

Brighton XI: Sanchez, Veltman, Dunk, Webster, March, Caicedo, Mac Allister, Estupinan, Gross, Trossard, Welbeck.

Subs: Lamptey, Colwill, Lallana, Sarmiento, Enciso, Undav, Mitoma, Steele, Gilmour.

Image source, .

Southampton boss Ralph Hasenhuttl makes six changes for the visit of Everton as Saints bid to bounce back from successive 1-0 away defeats at Wolves and Aston Villa before the international break.

There are first Saints starts for Ainsley Maitland-Niles, Juan Larios and Duje Caleta-Car, while Joe Aribo, Stuart Armstrong and Sekou Mara also come back in. Che Adams is fit despite being unwell on international duty with Scotland.

Southampton XI: Bazunu, Walker-Peters, Bella-Kotchap, Caleta-Car, Larios, Ward-Prowse, Maitland-Niles, Mara, Aribo, S Armstrong, Adams.

Subs: McCarthy, Perraud, Salisu, Edozie, Elyounoussi, Diallo, Walcott, Djenepo, A Armstrong.

Image source, BBC Sport

England goalkeeper Jordan Pickford returns from a thigh injury for Everton, who make two other changes from their first Premier League win of the season, a 1-0 victory over West Ham, a fortnight ago.

Seamus Coleman comes in for the injured Nathan Patterson, while Anthony Gordon drops to the bench in a slight surprise from Frank Lampard, with Dwight McNeil the man preferred instead.

But Dominic Calvert-Lewin is not yet back from a knee problem.

Everton XI: Pickford, Coleman, Coady, Tarkowski, Mykolenko, Onana, Gueye, Iwobi, Gray, Maupay, McNeil.

Subs: Begovic, Keane, Vinagre, John, Doucoure, Davies, Garner, Gordon, Rondon.

Image source, BBC Sport

It's four changes for Fulham from the side who beat Nottingham Forest, but the big news is Aleksandar Mitrovic is fit enough to start despite getting a knock on international duty.

In come Layvin Kurzawa, Nathaniel Chalobah, Daniel James and Kevin Mbabu for Issa Diop, Willian, Kenny Tete and Palhinha.

Fulham XI: Leno, Mbabu, Adarabioyo, Ream, Kurzawa, Chalobah, Reed, James, Pereira, Cordova-Reid, Mitrovic.

It's four changes for Newcastle as Callum Wilson returns to the starting XI after missing four matches with a hamstring injury.

He replaces Alexander Isak up top. Elsewhere, Sven Botman, Jacob Murphy and Sean Longstaff come in for Matt Targett, Ryan Fraser and Joelinton.

Newcastle: Pope, Trippier, Schar, Botman, Burn, Longstaff, Guimaraes, Willock, Almiron, Wilson, Murphy.

And now Arsenal make their move.

Thomas Partey and Oleksandr Zinchenko are off.

Albert Lokonga and Kieran Tierney are on.

Crystal Palace boss Patrick Vieira makes two changes from his side's 0-0 draw at Newcastle on 3 September with Nathaniel Clyne, Odsonne Edouard and Michael Olise all recalled to the line-up.

James Tomkins, who hasn't featured this season, is fit enough for a place on the bench having overcome a calf problem.

Crystal Palace XI: Guaita, Clyne, Ward, Guehi, Mitchell, Eze, Doucoure, Olise, Ayew, Edouard, Zaha.

Subs: Johnstone, Milivojevic, Tomkins, Mateta, Schlupp, Hughes, Ebiowei, Riedewald, Gordon.

Image source, BBC Sport

Graham Potter's first Premier League line-up as Chelsea boss features Pierre-Emerick Aubameyang, who makes his first league appearance for the Blues since arriving from Barcelona.

Two changes from Potter's first game in charge - a 1-1 Champions League draw with RB Salzburg - sees Ben Chilwell and Wesley Fofana replace Marc Cucurella and Cesar Azpilicueta.

Chelsea XI: Kepa, Fofana, Silva, Chilwell, James, Mount, Jorginho, Kovacic, Sterling, Havertz, Aubameyang.

Subs: Bettinelli, Pulisic, Loftus-Cheek, Chalobah, Broja, Ziyech, Gallagher, Koulibaly, Azpilicueta.

Image source, BBC Sport

Yves Bissouma, Davinson Sanchez, Ryan Sessegnon and Matt Doherty are all on for Tottenham.

Son Heung-min, Richarlison, Ivan Perisic and Clement Lenglet are off.

Phil McNulty
BBC Sport chief football writer at Emirates Stadium

What a catastrophic second half this has been for Spurs.

Hugo Lloris gifts Arsenal a second, Emerson Royal is shown red, then The Gunners add a third as Antonio Conte tries to make three changes.

One way traffic.

Image source, Getty Images

Clement Lenglet is in the way to clear it as Granit Xhaka drills it in from the left.

Those substitutions will happen now.

Glenn Murray
Former Crystal Palace striker on BBC Radio 5 Live

Martinelli drives in from the right hand side and Xhaka just takes the ball off his toes. He drills it back across Hugo Lloris, it was an emphatic finish into the bottom corner. The Tottenham players will be looking at Emerson Royal for that stupid challenge. It's killed the game now, it's killed Spurs' momentum.

Spurs wanted to make changes before conceding that goal and now they're making a whole host of them. At least four players are lining up on the touchline ready to come on.

Josh: Emerson only has himself to blame. I've seen them go for a lot less.

Guy: Emerson Royal is a poor player (for a squad of this standard) and that was a poor challenge but red card? Give over.

Image source, Getty Images

Arsenal look to punish Tottenham even more.

Bukayo Saka cuts inside and curls it towards the far corner but it's wide.

Ryan Sessegnon is getting ready to come on. Spurs are going to have to change shape to deal with their 10-man disadvantage.

Bound to be plenty of debate over that one.

Thumbs up for a red, thumbs down for a yellow?

Glenn Murray
Former Crystal Palace striker on BBC Radio 5 Live

That's a big big call, I'm not sure that's a straight red.

Uh-oh.

Tottenham's Emerson Royal is shown a straight red card as he catches Gabriel Martinelli on the back of his heel.

Replays show his studs were a bit high. Tottenham players think it's very harsh but he definitely scraped the ankle of Martinelli.

Image source, Getty Images