Image source, BBC Sport

Sutton's prediction: 2-1

I've been wrong about Manchester United a few times this season but I don't think their form has been that great recently, whatever their results have been like.

They were very fortunate to recover to beat Fulham in the FA Cup last time out, and that was not the only time recently where they got away with it a bit - they have not been at their best for a while.

It would still not surprise me at all if Erik ten Hag's side went to St James' Park and won but this is an enormous game in the fight for the top four and I am expecting Newcastle United to rise to the occasion.

I like the way the Magpies play and, although they have not always turned that into goals, they've had more of a cutting edge since Alexander Isak returned to full fitness. I have a feeling the Sweden striker will make the difference again here.

Tommy's prediction: 1-2

This will be close but I am going with Manchester United.

Find out what Sutton and O’Dell predicted for the rest of the weekend's games and cast your vote

Eddie Howe is not treating Newcastle's match against Manchester United as the opportunity for revenge in the Carabao Cup final but admits the occasion affected their league form.

The Red Devils clinched the season's first silverware with victory over the Magpies at Wembley in February, coinciding with a dip in form for Howe's side.

"We have had to move on very quickly," he said. "I don't think you ever fully get over a defeat but it's history so you tend not to dwell on it.

"The lads have recovered really well. I think the final was a distraction to our league form and you never know how a defeat can affect mentality.

"But the past two results [wins against Wolves and Nottingham Forest] have put us back on track."

Quickfire goals from Casemiro and Marcus Rashford settled the final and Howe said his players have learned from what happened.

"In that game, we conceded from a set-play and that was hugely frustrating because it swung the momentum their way," he said. "We did a couple of things wrong and got punished.

"I thought we were probably the superior team at that point but that made it difficult."

Asked about classic encounters between the two teams in the Premier League, Howe agreed the fixture had a rich history.

"I remember games with lots at stake and I always remember goals," he said. "Would love that to be the case and to be for us at the weekend."

Newcastle have turned St James' Park into a fortress this season. Only Liverpool have got the better of Eddie Howe's side on their own turf this campaign, and that was in part thanks to a red card for Nick Pope.

Interestingly, only three sides have conceded more away from home than the 27 of Manchester United this season - Bournemouth, Nottingham Forest and Leicester.

With Man Utd battling on numerous fronts, this is the first of nine fixtures for them in April. It's gonna be a tough old slog!

The Carabao Cup finalists lock horns again.

Man Utd prevailed at Wembley back in February to claim the first major piece of domestic silverware of the season. Newcastle will be looking to avenge that painful loss today.

Only two places and three points separate the two sides as it stands, with Champions League qualification the chief aim...

Image source, BBC Sport

Glenn Murray
Former Brighton striker on BBC Radio 5 Live

It's a massive three points, West Ham didn't play well in this very anxious stadium but they got the goal and held on to it.

They got the job done but they aren't the West Ham we're used too with the players they have. But they got those important three points and it's a little bit of a weight lifted for them.

Southampton will be very disappointed leaving here with nothing.

But there will be positives to take from their performance when the emotion has gone out of it.

Image source, Getty Images

West Ham crawl over the line to earn a precious three points.

They move out of the bottom three and leave Southampton where they started the day - bottom.

Image source, Getty Images

Glenn Murray
Former Brighton striker on BBC Radio 5 Live

West Ham are limping towards a massive three points here.

I wouldn't say they've been the better team.

Three added minutes. Again, that feels very short. How many subs have we had?

Nope. The corner clears everyone and trickles out for a goal kick.

West Ham win a corner as Michail Antonio is denied a shooting chance in the box. Can they make the closing stages much, much easier for themselves?

Aaron Cresswell and Manuel Lanzini are on for Lucas Paqueta and Emerson for the home side.

Wow!

Saints are knocking! James Ward-Prowse curls in a cross that Paul Onuachu meets with his head to crash an effort against the bar.

Unlucky for Southampton. A big let off for West Ham.

This is going to be a nervy last five.

Image source, Getty Images

Simon Stone
BBC Sport at the London Stadium

As Antonio Conte can testify, Southampton are capable of a late equaliser.

It doesn't look likely here though.

They just haven't passed the ball with any conviction.

Apart from those two saves from Lucasz Fabianski in the middle of the second half, they have created nothing.

That's a poor pass from Carlos Alcaraz. He has Kyle Walker-Peters to his right with Saints on the attack, but instead of making sure it reaches him he tries to anticipate a run that doesn't come and sends the ball inside a defender and straight out of play.