Quins made a strong start and win a penalty, but the decision is reversed following a clash between James Horwill and Sarries counterpart George Kruis at the breakdown.

After consulting with the television match official, referee Craig Maxwell-Keys sends Horwill to the bin.

Kruis has been stretchered off following lengthy treatment, and Maro Itoje is on in his place.

A reminder, if you missed the Leicester team news a few moments ago, that Manu Tuilagi is a late inclusion on the Tigers bench and could feature for the first time in 14 months...

After a slight delay at Sandy Park, Exeter's Gareth Steenson gets the game under way.

Harlequins fly-half Nick Evans gets us under way in the London derby at a sold-out Stoop.

Saracens are looking for a ninth consecutive league victory, which would be their best-ever start to a Premiership season.

Sarries have not lost to Quins since March 2012.

Remember, you can send us your thoughts on the day's action via Twitter.

Just tag #bbcrugby in your tweet and we'll include the best ones in our coverage throughout the afternoon.

We're just moments away from kick-off in our first two games, Harlequins v Saracens and Exeter v Gloucester....

Northampton make two changes to the side that beat Exeter, with captain Lee Dickson in at scrum-half for Kahn Fotuali'i, who drops out of the 23.

Jamie Elliott starts on the right wing, while Tom Wood and Tom Kessell are named among the replacements but England hooker Dylan Hartley is a late withdrawal from the bench because of a rib injury.

Image source, BBC Sport

Replacements: Williams, Waller, Denman, Day, Wood, Kessell, Myler, Mallinder.

Leicester include fit-again fly-half Owen Williams and bring in England front-row duo Tom Youngs and Dan Cole.

Peter Betham, Matt Smith and Adam Thompstone all start after missing the defeat by Saracens.

Centre Manu Tuilagi is a late inclusion on the bench and could play for the first time since October 2014, having been ruled out with an ongoing groin problem.

Image source, BBC Sport

Replacements: Thacker, Mulipola, Balmain, Pearce, Croft, Harrison, Burns, Tuilagi.

England's Ben Morgan returns to the Gloucester number eight spot.

Skipper Greig Laidlaw is back at scrum-half in the only other change to the side that beat London Irish.

Image source, BBC Sport

Replacements: Lindsay, Murphy, McAllister, Galarza, Moriarty, Heinz, Burns, Atkinson.

Exeter hand a first Premiership start to second row Ollie Atkins, as Mitch Lees becomes the latest Chiefs lock to be ruled out through injury.

Julian Salvi comes in at flanker, while Michele Campagnaro is dropped, with James Short starting on the wing and Jack Nowell moving to centre.

The Chiefs make a late change, with prop Alec Hepburn starting in place of Ben Moon, who drops to the bench.

Image source, BBC Sport

Replacements: Taione, Moon, Low, Hill, Horstmann, Lewis, Hooley, Campagnaro.

Unbeaten Saracens make seven changes to the side that beat Leicester, with Jim Hamilton and Jackson Wray returning to the forward pack..

Owen Farrell and Neil de Kock form a new half-back pair, and Mike Ellery and Duncan Taylor also come into the backs.

Hooker Jamie George captains the side, while England forward Billy Vunipola will make his 50th appearance for the north London club.

Image source, BBC Sport

Replacements: Saunders, Gill, Lamositele, Itoje, Burger, Wigglesworth, Hodgson, Tompkins.

Harlequins have made four changes to their side for the visit of Premiership leaders Saracens, who are looking for a ninth consecutive league win this season.

Rob Buchanan and Adam Jones come into the front row, Jack Clifford starts at number eight and Marland Yarde returns to the wing.

Image source, BBC Sport

Replacements: Ward, Adeniran-Olule, Gray, Merrick, Sloan, Dickson, Botica, Walker.

Quins make three late changes on the bench after Will Collier failed a late fitness test and Nick Easter misses out for personal reasons.

Joe Gray, Ben Botica and Charlie Walker come in, with Tim Swiel also dropping out.

You can listen to live radio commentary, courtesy of BBC local radio, of all three of today's matches.

Just click on the tab which says 'Live coverage' above and select which game you wish to listen to.

Image source, Rex Features

There may only be three games in the Premiership today but they are big ones.

League leaders Saracens - who remain unbeaten, having won 12 matches in all competitions this season - travel across London to The Stoop to face Harlequins, who are third in the table.

That match kicks off at 15:00 GMT, as does second-placed Exeter's match at home to Gloucester, who lie sixth.

Then fourth host fifth at 15:15 GMT when Leicester welcome Northampton to Welford Road.

The Premiership table could look very different come five o'clock....

Image source, Getty Images

Good afternoon and welcome along to our live coverage of today's three Premiership games.

With the top six all in action and a likely-to-be-feisty East Midlands derby between Leicester and Northampton, it promises to be an action-packed afternoon.

You'll find all the build-up, team news and regular updates from each match here.