London Irish head coach Tom Coventry makes 11 changes to the side which beat Agen to qualify for the European Challenge Cup quarter-finals last Saturday.

Topsy Ojo, Shane Geraghty, Conor Gilsenan and Luke Narraway are the only survivors from the starting line-up in France.

The Exiles will be without prop Ben Franks until the end of April after the All Blacks World Cup winner ruptured his bicep tendon.

Image source, BBC Sport

Replacements: Ellis, Harris, Halavatau, Sinclair, McCusker, Steele, Brophy Clews, Fenby.

Sale Sharks make three changes for the visit of London Irish, with Sam Tuitupou, TJ Ioane and skipper Dave Seymour all returning to the side.

Josh Beaumont starts after being released by England as the Sharks look to maintain their unbeaten home record, which has stood since April 2015.

Image source, BBC Sport

Replacements: Briggs, Harrison, Cobilas, Mills, Neild, Cusiter, Ford, Arscott.

First up we'll be bringing you all the action from the AJ Bell Stadium, so that's our cue to get cracking with a wee bit of team news...

After a two-week break for the European Champions Cup, it's all aboard the Premiership train once more.

And, with the Six Nations just around the corner, an opportunity for one or two to muscle their way in on the action still?

Here's what we'll be talking you through this afternoon...

• Sale v London Irish (14:30 GMT)
• Gloucester v Leicester (15:00 GMT)
• Saracens v Bath (15:15 GMT)