Wales beat France 14-13 to claim second place in the Six Nations
Earlier Ireland beat England 24-15 to secure their third Grand Slam
And Scotland won a thriller against Italy 29-27 in Rome
Highlights & reports of all three matches on the BBC Sport website
England 5-21 Ireland
Dennis Hickie
Former Irish wing Dennis Hickie on BBC Radio 5 live
It's a critical time in the game. Ireland have absorbed a load of pressure from England there and the home team have come away with nothing. This is the first time Ireland have been in the English half but they are keeping England at arms length.
England 5-21 Ireland
And Twickenham sounds like it has been relocated to downtown Dublin.
Ireland win a penalty as they turn the screw at scrum-time and the cheers around the ground are long and loud.
This could turn into a parade rather than a contest if Ireland get the next score...
England 5-21 Ireland
Comedian Dara O Briain making bad life decisions....
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England 5-21 Ireland
Chris Jones
BBC rugby union commentator at Twickenham
Sixteen points is England's joint biggest half-time deficit in the Five and Six Nations. Ever.
England 5-21 Ireland
Matt Dawson
Former Lions and England scrum-half on BBC Radio 5 live
Maro Itoje has been utterly ineffective and keeps making sloppy errors. He needs to come off and Joe Launchbury come in. England are attacking and getting into really good areas at the moment. There is a glimpse of hope for them. A try now would perhaps make the Irish a bit twitchy.
England 5-21 Ireland
David, below, I believe it is a France win tonight that would send England down to fifth.
Wales are already ahead of England in the Six Nations table and, at the moment, England are taking zilch from this match.
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Steve Jones, Rhondda: As a Welshman I love it when England lose and Ireland showing England how to finish off a Grand Slam final game is brilliant! They don't bottle it like those Rose red jerseys do regularly! Eddie jones for the sack?
Cameron Kelleher: Ireland in control of the Cold War at Twickers.
David Povey: So after Scotland won and England are losing, if Wales win would England finish 5th?!!
England 5-21 Ireland
Just the penalty against Elliot Daly. Anything else would have been harsh in the extreme.
But England away from the Ireland dangerzone with nothing to show once again...
Image source, ReutersEngland 5-21 Ireland
The below tweet was accompanied by an image of a black and cream alcoholic beverage. You can use your imaginations on that one.
Image source, U2England 5-21 Ireland
Elliot Daly's clear-out on Rob Kearney is heading upstairs for video review after the touch judge steps in to alert the referee to possible foul play.
It looks just about OK to me...
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Brian Driver: In the immortal words of John Cleese. I can cope with the despair. It’s the hope that’s killing me. Brian...in San Antonio. Home of the Alamo. Never surrender, England.
Simon Russell: As an English Rugby League fan, I want to thank the Irish Rugby Union for making my day
England 5-21 Ireland
The white wave crashes up against Ireland once again.
Mako Vunipola bashes up through the hard yards.
Johnny Sexton is back in harness for Ireland by the way after his first-half head knock.
England 5-21 Ireland
England have come out of the traps like they have not seen meat in a week.
Ben Teo crashes up to within 10, Elliot Daly darts for the corner...
A brilliant stretching tap tackle from Keith Earls sends the Wasps flyer stumbling and Ireland are saved.
Tiny margins, but they are all breaking Ireland's way.
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George: England need to take this game to Ireland second half. Farrell behaving like a football bachelor, time for Ford to replace him
Frankie, Blackheath: It's very hard to watch this game and support Ireland without shouting, when my 8 month old daughter is sleeping next door. Come on Ireland,
John Sutherland: Is it too late to give up watching English rugby for lent?
Sorry John, probably...
England 5-21 Ireland
Image source, OptaThese were the first half action areas.
Ireland spent a sliver of the time in the England half but came away with three tries.
England 5-21 Ireland
Paul Grayson
Former Lions and England fly-half on BBC Radio 5 live
England need to get their hands on the ball in the right areas and put some coherent play together. They've not had possession where they can hurt Ireland.
If they don't score early, they will be staring down the barrel.
England 5-21 Ireland
And we are back under way.
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Luke: People talk about England being the only team that could match anew Zealand, looks a long way off now. The ill discipline is a disgrace.
Mike Greenwood: England indiscipline getting what it deserves......again!!
Glyn Jones: Ireland are so good at turning the screw right at the break. Not a bad talent to have
HT: England 5-21 Ireland
Sonja McLaughlan
Rugby union reporter on BBC Radio 5 live
Image source, BBC SportEngland v Ireland showing on the big screens in Cardiff. Fans who've arrived early to watch events in Twickenham showing their allegiance by clearly supporting the Irish!
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Straight Edge Patriot: A record breaking winning run, 2 x Six Nations titles and people calling for Eddie Jones' head?! Behave!
Tris: England have got progressively worse with every game in this Six Nations - what on earth are they doing on the training ground?