Late Billy Vunipola try sees Saracens come from behind to win at Saracens
First-half Danny Care score and remarkable Joe Marchant try had seen Quins lead for much of second half
Leicester beat Northampton at Twickenham in Rob Horne send-off
Gloucester secure bonus-point win at Wasps
Sale leapfrog Newcastle at bottom with win over Falcons
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Northampton v Leicester (15:00 BST)
Image source, James Burridge - BBC SportNorthampton and England flanker Tom Wood has been telling 5 live sport about how Rob Horne's retirement has impacted on the Saints squad.
"This took us all off guard. It is heartbreaking. Rob is a warrior of a bloke," he said.
"He was the best of us in an off day. I'm proud of Leicester and Northampton to do this in Rob’s name."
Northampton v Leicester (15:00 BST)
As we've told you, this afternoon's East Midlands derby is all about Rob Horne.
BBC Look East's James Burridge caught up with the former Wallaby at Twickenham to look back at his career and the incident that left his right arm paralysed and facing retirement.
Rob Horne: 'No regrets' for ex-Australian and Northampton star
Wasps v Gloucester (15:00 BST)
Image source, BBC SportFor their away trip Gloucester head coach Johan Ackermann has decided to stick with a trusted formula.
The recently named Gallagher Premiership Player of the Month, Danny Cipriani, starts at fly-half and the one amendment to their XV comes just outside of him.
Billy Twelvetrees replaces Henry Trinder at outside centre and Twelvetrees will partner Mark Atkinson in the midfield.
Wasps v Gloucester (15:00 BST)
Image source, Getty ImagesAhead of Wasps’ encounter with the Cherry and Whites, Dai Young has made a plethora of changes including Billy Searle taking Lima Sopoaga’s place at fly-half. The All Black is unavailable due to a neck injury.
Elsewhere, Young’s amendments include a brand new front row of Ben Harris, Tommy Taylor and Kieran Brookes plus Christian Wade is recalled out wide.
Sale v Newcastle (15:00 BST)
Image source, BBC SportScrum-half Michael Young will make his first start of the new season after a successful return from injury. His inclusion is the only change to the Falcons side that met Wasps last time out.
Kyle Cooper, David Wilson and Ryan Burrows all come onto the bench after performing well for the A-Team on Monday night.
Sale v Newcastle (15:00 BST)
Image source, Getty ImagesJames O'Connor scoring a try against Bath in December 2017.
"I want to be playing on the field and playing at the top level, and I don't want anything to be getting in the way."
This week, James O’Connor spoke to our BBC Radio 5 live rugby union reporter Chris Jones. The 44-cap Australian has suffered with chronic ankle issues but is set to return and try to add considerably to his 13 appearances for Sale.
O’Connor opens up about some of the disciplinary issues that he went through in France and also discusses his international ambitions.
Read the full article here.
Sale v Newcastle (15:00 BST)
Image source, BBC SportElsewhere this afternoon, James O’Connor is back in Sale’s match-day squad and it’s six months to the day since his last appearance for them against Wasps.
AJ MacGinty is named at fly-half while Sam James will run out at full-back. Byron McGuigan shifts onto the wing due to Denny Solomona's absence through injury.
Northampton v Leicester (15:00 BST)
Image source, Getty ImagesManu Tuilagi's return is one of four changes for Leicester
Internationals Ben Youngs and Manu Tuilagi are back in Leicester’s starting line-up – Youngs appeared off the bench last week while Tuilagi wasn’t part of their round five match.
Jonah Holmes also comes into the backline and there is one change in the forward pack - Harry Wells replaces Graham Kitchener.
On the bench, interim head coach Geordan Murphy continues to put his faith in the club’s young talent with a quartet of England U20s players - Joe Heyes, Sam Lewis, Tom Hardwick and Jordan Olowofela - ready to emerge when required.
Northampton v Leicester (15:00 BST)
Image source, BBC Sport… And so to the team news for Northampton.
Chris Boyd has made two changes to his starting XV with full-back Harry Mallinder and centre Andrew Kellaway coming into the starting team for the first time this season.
Piers Francis is unavailable for the fixture and Ahsee Tuala switches to the wing.
Northampton v Leicester (15:00 BST)
James Burridge
BBC Radio 5 live sports extra commentator at Twickenham
It’s chucking it down at Twickenham. Northampton arrived just before 1.30pm to a chorus of ‘Come on You Saints’.
Image source, James Burridge - BBC Sport
Image source, James Burridge - BBC SportNorthampton v Leicester (15:00 BST)
Image source, Getty ImagesNorthampton have been raising funds for Rob Horne since this special derby match was announced in August. The club’s aim, quite simply, is to raise as much as possible for his family and his ongoing rehabilitation.
The club has donated £5 on behalf of every season ticket holder to get the ball rolling, and thousands of pounds have since been raised with supporters also contributing during match ticket purchases.
Northampton v Leicester (15:00 BST)
Saracens’ Brad Barritt hits the nail on the head with his words here.
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Northampton v Leicester (15:00 BST)
Image source, Getty ImagesThe afternoon’s action starts at the home of England Rugby for a very, very good reason. Today Twickenham Stadium has opened its doors for ‘The Derby’, a vitally important match that is being played in aid of an inspirational man.
On 14 April this year Rob Horne’s life changed forever after a routine hard tackle at the start of Northampton’s East Midlands derby at Leicester. The tackle left him with severe nerve damage and paralysis in his right arm.
The manner in which Horne is handling such a life-changing injury is truly inspiring as you can see from his words below.
"I was probably in shock for a while, but I didn't get that low. A lot of people close to me were a bit worried that I was coping too well. How I responded to that was 'who says you have to hit rock bottom to bounce back?'”
Exeter continue winning start
Image source, Getty ImagesThis weekend's Premiership action began last night, with Exeter running in five tries at Bath to make it a perfect six wins from their opening six Premiership matches.
In case you missed the action, here's a handy link to the match report.
Exeter make it six wins from their opening six Premiership matches as they run in five tries at Bath.
Read MorePremiership Saturday
Today the Premiership is spoiling us all with no less than four matches.
We’re going to be starting and finishing in south west London with the two other matches will be taking a place a little further north in Salford and Coventry respectively.
We’ve got full text commentary for you right here, plus you can select your BBC Radio Commentary of choice at the top of this page.
Premiership Saturday
Image source, Rex FeaturesGood afternoon and a very warm welcome to our coverage of round six of the Premiership season.
It’s the final round of domestic action for all before the European competitions arrive and every team running out this weekend will be looking to sign off this first block of domestic fixtures with a W.
We’re going to be with you right the way through this afternoon and evening and it should be another corking day of domestic rugby.