How England line up...published at 16:28 Greenwich Mean Time 31 October 2020
Italy v England (16:45 GMT)
England head coach Eddie Jones has been forced to contend with several injury problems - fly-half George Ford, full-back Elliot Daly, centre Manu Tuilagi, prop Joe Marler and second row/blind-side Courtney Lawes are the most notable absentees - and means there will be several debutants involved in Rome.
Exeter's double-winning lock Jonny Hill, who starred as the Chiefs won a domestic and European double this month, is one of them and joins Maro Itoje in the second row.