Not the happiest of welcomes for Stuart. Vincent Koch nails Joe Marler and South Africa win a penalty.

Frans Steyn kicks to touch inside England's half.

Kyle Sinckler trots off the pitch too as Will Stuart comes on to see what he can do against South Africa's fearsome front row.

Stuart is straight into the action as well. It's a Springbok scrum.

Chris Jones
BBC rugby union correspondent

South Africa are starting to win scrum and breakdown penalties. England need to change the pictures in the referee’s mind or they are in trouble here.

That is Handre Pollard's last kick of the game as he is replaced by Elton Jantjies.

Alex Dombrandt is on for England in the back row.

Yep, no issues this time.

Just two points in it now with 25 minutes to go.

First Siya Kolisi, then Damian de Allende burst their way over the ganline.

Replacement full-back Frans Steyn sends a tester to Jonny May and Freddie Stewards kicks the ball back for South Africa to go again.

Sam Underhill looks up in disbelief as he is penalised on the floor and this will be another chance at three points for Handre Pollard. Surely he won't miss three in a row.

Handre Pollard goes to the air instead but England have Freddie Steward remember.

As solid as he has been all autumn, Steward calls the mark and clears to touch.

South Africa's up-front dominance continues as their maul rolls deeper into England's half.

The hosts work hard at the breakdown but to little effect and the Springboks creep closer to the 22.

Image source, Getty Images

Quirke won't get the chance to see what he can do off the back of England's scrum because the hosts have given away a penalty again.

Kyle Sinckler is starting to suffer against the Springboks' fresh front row.

Whether you like him or not, Ben Youngs has left the field.

Twenty-year-old Raffi Quirke is on for surely the biggest 30 minutes of rugby he has ever player.

Ralph Brooker: Re Ben Youngs going understated. A few years back there were calls for his blood saying he was past it!

Tanzim: I hate Ben Youngs. What does he actually offer other than a box kick every 10 seconds?

You win some, you lose some.

Joe Marler - hopefully a one-man bomb defusal service - comes on to counteract those South Africa front row replacements.

Bevan Rodd leaves the field.

This is not in the script.

Handre Pollard misses another penalty and in further news to cheer the Twickenham crowd...

Freddie Steward deals coolly with an aerial bombardment.

But Kyle Sinckler ends up juggling the ball with Malcolm Marx running at him. Not at all a position you want to find yourself in.

The result is another penalty for South Africa as Sinckler rolls his eyes at the big-screen replay.

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Marek: Is the South African medic on the touchline that you can see at each scrum coaching at the same time?

Cedric David: No Farrell, no Ford, and (yet) a much improved England! Splendid play by dynamic new players like Steward, Malins or Smith!

Siya Kolisi has a go on the right wing, but his offload to Jesse Kriel goes into touch and it's another get out of jail free moment for England.

The hosts retain their five-point lead and are really going to have to dig in now.

Chris Jones
BBC rugby union correspondent

'Bomb Squad' on after 44 minutes. Will their influence decide the match?

A new South African front row of Vincent Koch, Malcolm Marx and Steven Kitshoff take to the field.

Will Joe Marler be brought on for England to counteract their impact?

South Africa's forwards create the opportunities, but this time Handre Pollard can't deliver the goods.

But here come the Springboks' scrum reinforcements...

Image source, Getty Images