Image source, Getty ImagesDominic Calvert-Lewin is set for another spell on the sidelines after sustaining a hamstring injury.
Manager David Moyes says the striker will require a "specialist opinion", with him expected to be out of action "for a number of weeks".
What now Toffees fans? How will Moyes get around another injury setback for the team?
And where will the goals come from?
Michael Emons
BBC Sport journalist
Image source, Getty ImagesLiverpool boss Arne Slot says the season is going even better than he had expected.
"You don't think after 20 games we will have that many points and I wasn't expecting us to be top with the margin we have," he told Gary Lineker in an interview for Football Focus.
"It's always nice to be up there, but nobody would have expected this. I'm the last person who would have expected [reigning champions Manchester] City to have such a bad run."
Slot signed a three-year contract with Liverpool last summer, and is already thinking how the club can improve.
"Liverpool should always be competing for a league title - we should always be competing for the Champions League. I'm hoping I will be able to keep the club at that level," he said.
"I know people sometimes question this because they haven't seen us doing a lot in the transfer market in the summer and now in the winter as well. There's a reason for that - because we're happy with the squad.
"But I do know we're definitely working on strengthening in the summer."
During his playing days, Slot was a goalscoring attacking midfielder, twice winning promotion from the Dutch second division to the Eredivisie with FC Zwolle and also playing in the Uefa Cup with NAC Breda.
But a route into coaching was a natural progression for Slot, who managed Dutch sides Cambuur, AZ Alkmaar and Feyenoord, where he won the league title, before moving to Liverpool.
"I don't think anyone that played with me is surprised I've become a manager," he added. "It didn't take long before I thought 'I'm going to enjoy this for as long as I can and I definitely want to become a manager or a coach'."
Image source, Getty ImagesIt is fair to say that Everton are having the new-old manager bounce. With David Moyes coming back in, they have created a bit of daylight between themselves and the bottom three.
But one thing that is still apparent, for as good as their defensive record is, they have still only scored 19 goals. That has become a problem.
The injury to Armando Broja, the fact that Beto has not scored too many - and neither has Dominic Calvert-Lewin - means goals are going to play a big part in how they finish this season.
Moyes knows giving the Everton fans something to look forward to watching does require goals. So they are going to need somebody up there that could maybe combine in a 4-4-2 formation or is capable of leading the line themselves.
Having a finisher changes the way teams are perceived and how you play against them. I would not say who Everton get has to be from the Premier League because there are so many hidden gems in the football league and elsewhere. Ultimately, price will be a big factor.
And that is the thing with Everton - where the player comes from is not a big deal. Look at someone like Seamus Coleman - a club legend who was brought in for £100,000 from Ireland. The profile does not matter as long as they buy into the identity of the football club.
This is an important season for Everton, not just for staying in the league, but for the feeling as they go over to the new stadium. If they are scoring goals, and playing exciting football, then there are reasons to believe something good is coming.
Nedum Onuoha was speaking to BBC Sport's Nicola Pearson
We asked for your thoughts after Wednesday's Champions League game between PSV and Liverpool.
Here are some of your comments:
Paul: This was a game of no real consequence for us. The kids were given a run out and the first-team were rested. We are top of the leagues. Bring on Bournemouth!
Faiyaz: An atrocious performance. We deserved to lose.
Ian: I don't know what Arne Slot was thinking, but I feel sorry for the travelling fans who spent a lot of money to sit and watch a bunch of kids be totally outclassed and given the run-around. It won't have done much for their confidence.
Adrian: I'm not sure what Slot gained from this. We want to keep the winning mentality but some of the young players will be disappointed with that result. OK he gets to rest key players, but I think this backfired a little.
Vinkhu: The boys did us proud against a full first-team. We can look forward to a good team in the future. Although Bradley had a relatively poor game, most of our young stars did extremely well in the circumstances.
Alan: How can we keep a player like Elliott? He is a joke, he can't tackle and he has no pace. Please get rid - that is if anyone will take him.
Want to hear more analysis of a gripping night in the Champions League?
BBC Radio 5 Live's Football Daily podcast has reaction to games involving Arsenal, Aston Villa, Liverpool and Manchester City.
All four English clubs remain in the competition at the conclusion of the League Phase.
Image source, Getty ImagesThose finishing in the top eight automatically progress to the last 16, where they will be seeded.
They will await the winners of eight two-legged knockout play-off ties featuring the clubs ranked from ninth to 24th.
Liverpool could possibly face the following four teams - PSG, Benfica, Monaco or Brest.
Arsenal could possibly face the following four teams - AC Milan, PSV, Feyenoord or Juventus.
Aston Villa could possibly face the following four teams - Atalanta, Borussia Dortmund, Sporting Lisbon or Club Brugge.
Image source, Getty ImagesFormer Premier League defender Stephen Warnock praised Liverpool head coach Arne Slot on Match of the Day for the way he has rotated his squad in the Champions League.
The fixtures keep on coming for Slot's Reds, who are still competing on four fronts, so with a place in the last 16 guaranteed, Slot rested a number of key players against PSV Eindhoven.
"Job done," said Warnock. "Perfect for them to be able to rest players as that was important.
"He [Arne Slot] has taken this competition very seriously. I looked at the team last week against Lille and thought - why have you gone so strong? But it was so they were ready to rest in this game."
Neil Johnston
BBC Sport journalist
Image source, ReutersArne Slot's return to the Netherlands might have ended in defeat.
But Liverpool still finished top of the 36-team league phase of the Champions League and will face one of Paris St-Germain, Benfica, Monaco and Brest in the last 16 in March.
Before then at least seven league and cup matches as the Premier League leaders continue to chase trophies on four fronts.
The likes of Mohamed Salah, Virgil van Dijk and Trent Alexander-Arnold were all rested against PSV Eindhoven before the crucial game at Bournemouth on Saturday.
Instead highly-rated youngsters Jayden Danns and James McConnell were given a chance to show what they could do, while Federico Chiesa got 90 minutes in the tank after his injury problems.
Chiesa looked lively and posed a real threat as the Italy forward registered two of his side's five attempts on target.
In addition, he won the penalty which allowed Cody Gakpo to score against his former club in his home city and was also heavily involved in his side's second goal.
The key for Liverpool going forward is keeping Chiesa fit.
Image source, Getty ImagesLiverpool midfielder James McConnell, speaking to TNT Sports: "Disappointed we didn't win the game but we topped the group thanks to the performance in the rest of the season.
"I'm proud to make my Champions League debut. I'm grateful for the opportunity. I loved playing in this atmosphere.
"The team was a bit makeshift at times with lads slotting in all over the place but we feel we should have won the game."
Image source, Getty ImagesIn Conor Bradley, Harvey Elliott, James McConnell, and Jayden Danns, Liverpool started four players aged 21 or younger in a Champions League game for the first time since December 2006 against Galatasaray.
