Team news
Manchester United midfielder Kobbie Mainoo is in line to return after a two-month absence with a calf injury.
Matthijs de Ligt is a doubt after picking up an injury against Nottingham Forest, while Ayden Heaven, Jonny Evans, Lisandro Martinez and Luke Shaw are all still out.
Manchester City's Manuel Akanji, Nathan Ake, Erling Haaland, Rodri and John Stones remain on the sidelines.
Defender Abdukodir Khusanov is in contention, having been rested for the midweek win over Leicester City.
Match facts
Head-to-head
Manchester United are aiming to complete their first league double over Manchester City since the 2019-20 campaign.
City's nine away wins at Old Trafford is the most by any side in the Premier League. Five of those victories have come under Pep Guardiola, the most of any visiting manager in the competition.
United are aiming to go four matches without defeat against City for the first time since January 2010 to February 2011.
The away team has won 10 of the last 18 league meetings between these sides. Since the 2015-16 campaign, the only Premier League fixture with more away wins is Crystal Palace versus Liverpool (12).
Manchester United
Manchester United have lost 13 times in the Premier League this campaign, one short of their club record of 14, set last season.
United have failed to score in 10 of their 30 league matches this term.
The Red Devils have earned just two points in eight home league games against sides starting the day in the top half of the table (D2, L6). They have scored just five goals in those matches and have conceded 19.
United need to win all eight of their remaining top-flight games this season to avoid recording their lowest points tally in a Premier League season - currently 60, set under Erik ten Hag last season.
Having already recorded wins against City with Sporting and Manchester United this season, Ruben Amorim is aiming to become just the third manager to beat Pep Guardiola in three consecutive meetings, after Jurgen Klopp with Liverpool (twice) and Thomas Tuchel with Chelsea.
Amorim has the lowest win rate (31.6%) and points-per-game average (1.16) of any Manchester United manager in the Premier League.
United have conceded the opening goal 23 times in all competitions this season, the second-highest tally by a Premier League club, behind Leicester City's total of 25.
Sir Alex Ferguson lost 114 of his 810 Premier League games as Manchester United manager (14.1%), while the 10 managers in charge since his departure have totaled exactly the same number of defeats in just 448 matches (25.4%).
Manchester City
Manchester City have won their last 14 league games in April.
Six defeats in their last 11 top-flight away matches (W3, D2) is as many as they had suffered in their previous 37 combined.
The only time in the last 13 seasons that they have lost more than six league away games was when they were beaten seven times in 2019-20.
City have scored just five goals in their last five league matches.
Savinho is the first player to assist eight Premier League goals in a season before the age of 21 since Liverpool's Trent Alexander-Arnold registered 12 in 2018-19 and the first non-Englishman to do so since Cesc Fabregas recorded 17 for Arsenal in 2007-08.
All five of Omar Marmoush's five league goals for City have come at the Etihad.
