Manchester City are also going to make a change.

Jeremy Doku replaces Savinho.

Image source, Reuters

Palace make a quick change before the dropped ball. On comes Eddie Nketiah for Ismaila Sarr.

This time the dropped ball is dealt with.

On comes Ben Brereton Diaz for Southampton as they chase an equaliser. Flynn Downes makes way.

Erling Haaland goes close from the corner but again it takes a deflection and City have another one.

This time it's cleared away and there's a coming together between Will Hughes and Ruben Dias which results in a dropped ball. The last City goal came from the same scenario. Palace will need to be a bit more switched on for this one.

Martin Keown
Former England defender on Final Score

The Rico Lewis goal was a thing of beauty. The combination passing, the triangles.

Lewis whips it into the corner and finishes like a striker.

Both sides make changes as they look to try and get the crucial next goal.

Kevin Schade and Mikkel Damsgaard are on for Brentford, replacing Fabio Carvalho and Thiago.

For Newcastle, Miguel Almiron and Callum Wilson replace Sean Longstaff and Harvey Barnes.

Manchester City probing for that third goal.

Good play from the visitors and Bernardo Silva lays it off for Savinho but his shot takes a slight deflection and Dean Henderson paws away for a City corner.

Simon Stone
BBC Sport's chief football news reporter at Old Trafford

Leny Yoro is handed his full debut as Manchester United boss Ruben Amorim makes five changes to the side beaten at Arsenal on Wednesday.

Lisandro Martinez and Kobbie Mainoo return after suspension, while Amad and Rasmus Hojlund are also back.

Marcus Rashford, Mason Mount and Harry Maguire are among those who drop to the bench. Antony misses out completely.

Manchester United XI: Onana, De Ligt, Martinez, Yoro, Amad, Dalot, Mainoo, Ugarte, Fernandes, Garnacho, Hojlund.

Subs: Bayindir, Mazraoui, Maguire, Mount, Casemiro, Eriksen, Rashford, Malacia, Zirkzee.

Callum Hudson-Odoi returns for Nottingham Forest as one of three changes to the side beaten at Manchester City on Wednesday.

Neco Williams and Elliot Anderson also return and veteran central defender Wily Boly is on the bench as he looks to play for the first time since August. Forest have lost 12 of their past 13 encounters with Manchester United in all competitions.

Nottingham Forest XI: Sels, Murillo, Williams, Anderson, Milenkovic, Aina, Yates, Gibbs-White, Hudson-Odoi, Silva, Wood.

Subs: Awoniyi, Morato, Toffolo, Dominguez, Elanga, Sosa, Boly, Ward-Prowse, Carlos Miguel.

On comes Justin Devenny for Eberechi Eze.

Paul Robinson
Former England goalkeeper on BBC Radio 5 Live

You feel that this is a key moment, not just in the game but for Manchester City's season.

If they turn this around, Guardiola will be telling us in his post-match all about the character of his team.

They have been more like the Manchester City of old today.

Image source, Getty Images

Manchester City desperate for a third goal here.

Rico Lewis scored the equaliser, his first league goal of the season, but now finds himself in the referee's book for a foul in the middle of the park.

Southampton make a change with 20 minutes to go. Cameron Archer is replaced by Sam Amo-Ameyaw.

Paul Robinson
Former England goalkeeper on BBC Radio 5 Live

What a brilliant finish.

Crystal Palace aren't happy with the quick restart. It is slipped through to Rico Lewis and snaps it into the top corner, giving Dean Henderson no chance. What a finish.

Morgan Rogers is allowed to surge forward through the middle. He gets to the edge of the box before his shot takes a little deflection off Taylor Harwood-Bellis. It is another Aston Villa corner, but it comes to nothing.

Martin Keown
Former England defender on Final Score

I think the conditions are playing a part. Fabian Schar would normally get his head on that.

Nathan Collins tucks it away and it's a beautiful finish.

Image source, Getty Images

Still plenty of time for Manchester City to turn this around with 25 minutes left to play but indeed, things are just not right with Pep Guardiola's side at the moment.

Aston Villa win a few corners in quick succession as Southampton struggle to get the ball away. Eventually they do and then break forward through Cameron Archer, but his shot inside the box is blocked.

The Saints are still in this.

Clever play from Rico Lewis down the left-hand side but there's no one in a City shirt in the six-yard box to meet his square ball.