Manchester City have won five of their last eight Premier League matches against Manchester United (D1 L2), though they failed to win either game (D1 L1) last season for the first time since 2020-21.

Manchester United have inflicted 25% of Pep Guardiola’s total home Premier League defeats as Man City manager, with the Red Devils winning four times there against the Spaniard (4/16). They are looking for consecutive wins at the Etihad for the first time since March 2021.

Since 2015-16, the home team has ended on the winning side in just six out of 20 Premier League meetings in the Manchester derby (D4 L10). Indeed, since then, the only Premier League fixture to see more away wins (10) is Crystal Palace vs Liverpool (12).

Manchester City have lost two of their first three Premier League matches for the first time since the 2004-05 campaign (W1), while it is the fewest points (3) ever collected by Pep Guardiola in his first three league games of a season. The last time City lost three of their first four games was in 1995-96, a season they were eventually relegated.

Manchester United registered their eighth win in 30 Premier League matches under Rúben Amorim (D7 L15) thanks to their 3-2 win over newly promoted Burnley on MD3. Half of Amorim’s wins have been against promoted sides, with the Portuguese manager holding just a 16% win ratio against sides not promoted to the division that campaign (4 wins in 25).

Manchester United have had 58 shots in the Premier League this season, 14 more than any other side. It’s their most shots in the first three games of a season since 2017-18 (60).

Pep Guardiola has lost 49 of his 345 Premier League matches (W247 D49), with 22% of those coming since the start of last November (11). A defeat in this game would see him take the second largest number of games to lose 50, behind Sir Alex Ferguson, whose 50th defeat wasn’t until his 367th match.

Manchester United have made the most off-ball runs in behind their opponent’s defensive line in the Premier League this season (131), with forward Bryan Mbeumo responsible for 54 of those – the most of any player. Three of the five most in-behind runs by a player in a match so far in 2025-26 have been Mbeumo, with a high of 22 against Burnley last time out.

Man Utd captain Bruno Fernandes has created the most chances in the Premier League this season so far both overall (12) and in open play (8). Fernandes has also scored in each of United’s last three wins against Man City in the competition (March 2021, January 2023, December 2024).

Both Man City’s Gianluigi Donnarumma and Man Utd’s Senne Lammens could make their Premier League debuts in this game. Excluding MD1 games, in only two Premier League games have both clubs given a debut to goalkeepers: Nottingham Forest (Andy Marriott) vs Spurs (Kevin Dearden) in April 1993 and Charlton Athletic (Darren Randolph) vs Liverpool (Daniele Padelli) in May 2007.