PENALTY SHOOT-OUTpublished at 21:59 British Summer Time 17 September
FT: Preston 1-1 Fulham
A chance to win the match and it is a shocking penalty from Preston's Kaine Kesler-Hayden, saved. We continue.
FT: Man Utd 7-0 Barnsley
FT: Preston beat Fulham in dramatic shootout
FT: Southampton beat Everton on penalties, Stoke beat Fleetwood
FT: QPR 1-2 Crystal Palace, Blackpool 0-1 Sheffield Wednesday, Brentford 3-1 Leyton Orient
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Michael Emons, Alastair Telfer, Ian Woodcock & Tom Rostance
FT: Preston 1-1 Fulham
A chance to win the match and it is a shocking penalty from Preston's Kaine Kesler-Hayden, saved. We continue.
FT: Preston 1-1 Fulham
Freddie Woodman makes a fine save to deny Cuenca. Preston now have a chance to win an epic shootout.
FT: Preston 1-1 Fulham (7-7 on pens)
Great penalties at Deepdale. It's seven-all, neither keeper really got close to saving one yet.
Brentford 3-1 Leyton Orient
Brentford get the job done after a nervy start.
Manchester United 7-0 Barnsley
Paul Robinson
Former League Cup winning goalkeeper on BBC Radio 5 Sports Extra
They've done all they could tonight Manchester United.
At home against a League One side, you're expected to win and you're expected to win well and this side did exactly that.
There were top performances from Rashford, Garnacho, Antony, Eriksen got a couple of goals.
They were open and expansive. They were always looking for more goals, they looked sharp, they pressed from the front.
Erik ten Hag will be delighted with the way his team have played and especially the result.
FT: Preston 1-1 Fulham (5-5 on pens)
Five-all in a top-quality shoot-out. On to sudden death.
Barnsley have been put out of their misery. Two goals for Marcus Rashford, one for Antony, two either side of the break from Alejandro Garnacho and two late on from Christian Eriksen.
United cruise through, scoring seven against League One Barnsley.
FT: Preston 1-1 Fulham (2-2 on pens)
At Deepdale, the first four penalties have all been converted, two each.
FT: Everton 1-1 Southampton (Southampton win 6-5 on pens)
Southampton win on penalties.
Everton's Ashley Young steps up and it is saved. Alex McCarthy stands his ground and pushes it away. A poor penalty from such an experienced player.
The only miss.
Manchester United 7-0 Barnsley
Paul Robinson
Former League Cup winning goalkeeper on BBC Radio 5 Sports Extra
We might be safe, I don't think we're going to penalties.
I think it would be some kind of record for an away team to score seven at Old Trafford, never mind in the minutes we have remaining.
FT: Preston 1-1 Fulham (0-1 on pens)
Raul Jimenez, who came on late on for Fulham, gets the penalty shoot-out under-way at Deepdale by putting the Premier League side ahead.
FT: Everton 1-1 Southampton (5-5 pens)
Cool as you like from Everton's Jack Harrison.
FT: Everton 1-1 Southampton (5-4 pens)
Joe Aribo's cool pen for the Saints means Jack Harrison has to score.
Manchester United 7-0 Barnsley
Paul Robinson
Former League Cup winning goalkeeper on BBC Radio 5 Sports Extra
Emphatic by Manchester United. It is becoming embarrassing for Barnsley, they're getting cut open at will.
It's the quality, the interchange that they've got in around the box.
It just comes to Christian Eriksen at the end of the box, so simple for him, he just casually curls it into the bottom right hand corner.
Can they get any more?
FT: Everton 1-1 Southampton (3-3 on pens)
Make that six from six.
FT: Everton 1-1 Southampton (2-2 on pens)
Perfect penalties so far.
Ross Stewart slots his into the corner for the Saints. The first four are all successful.
Christian Eriksen (85 mins)
Two goals in four minutes for Christian Eriksen, again coming from a Bruno Fernandes assist.
United hit seven and Barnsley are getting humiliated.
Preston 1-1 Fulham
Penalties at Deepdale.
Manchester United 6-0 Barnsley
Paul Robinson
Former League Cup winning goalkeeper on BBC Radio 5 Sports Extra
It's all too easy for Manchester United.
Christian Eriksen actually got the turnover of possession, won the ball in his own half, played it out to Garnacho, who in turn found Bruno Fernandes who whips the ball across the six yard box.
Eriksen follows up his run, he's run half the length of the pitch, opens the right foot up, quite comfortably places it with his side foot into the back of the net.
This game has been over for a long, long time.
It's been a training exercise.
QPR 1-2 Crystal Palace
Crystal Palace went strong and get their rewards by moving into the last 16. Eddie Nketiah got his first goal for the club, QPR equalised early into the second half through Sam Field but Eberechi Eze, against his former side got a deflected winner.