Postpublished at 21:22 British Summer Time 17 September
Stoke 1-0 Fleetwood
It's tense in Stoke as we reach the last few minutes and just the one goal in it...
FT: Man Utd 7-0 Barnsley
FT: Preston beat Fulham in dramatic shootout
FT: Southampton beat Everton on penalties, Stoke beat Fleetwood
FT: QPR 1-2 Crystal Palace, Blackpool 0-1 Sheffield Wednesday, Brentford 3-1 Leyton Orient
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Michael Emons, Alastair Telfer, Ian Woodcock & Tom Rostance
Stoke 1-0 Fleetwood
It's tense in Stoke as we reach the last few minutes and just the one goal in it...
Preston 1-1 Fulham
Emile Smith Rowe and Alex Iwobi come on for Harrison Reed and Harry Wilson. Fulham want a winner!
Manchester United 5-0 Barnsley
Paul Robinson
Former England goalkeeper on BBC Radio 5 Sports Extra
It's that link up again between Garnacho and Rashford but you see what it means to Manchester United.
They look like a squad that are together, all celebrating in this bottom left-hand corner with the substitutions.
Barnsley lose out on possession, Garnacho puts Rashford through, simplest of tasks, one on one with the keeper.
It's really a case now of how many do you want Manchester United?
They're far superior. Barnsley can be opened up at will.
Marcus Rashford
Barnsley are falling apart.
They gift the ball to Manchester United, Alejandro Garnacho, who has two goals, slides a pass through to Marcus Rashford and he too gets a double, shooting low, first-time past Gaga Slonina for United's fifth.
Plenty of time for more too.
Brentford 3-1 Leyton Orient
A second yellow for Jack Simpson and off he goes. It could get bad for the League One side.
Everton 1-1 Southampton
Shamoon Hafez
BBC Sport football news reporter at Goodison Park
The mood from the home faithful is threatening to turn mutinous.
There were very loud jeers when boss Sean Dyche decided to hook striker Beto and bring on full-back Ashley Young instead.
Now every misplaced pass or one that goes backwards instead of forwards is being met with huge groans.
Everton 1-1 Southampton
Sean Dyche brings on Ashley Young for Beto, which receives boos from the Everton fans. Settling for pens?
Manchester United 4-0 Barnsley
Paul Robinson
Former England goalkeeper on BBC Radio 5 Sports Extra
Well whatever Barnsley manager Darrell Clarke said at half-time, forget it, that's it.
The Barnsley boss has been trying to sort his team out, made three changes and within four minutes, they've been exposed.
Turnover of possession, one long ball through, Garnacho is completely unmarked. He has half of the length of the pitch, the freedom of Old Trafford, looks up once, slots it round the keeper.
It's going to be a long 40 minutes for Barnsley.
Alejandro Garnacho
One-touch football from Manchester United in their own half and Christian Eriksen plays it through to Alejandro Garnacho, who has so, so much space.
He scored at the end of the first half and gets his second and United's fourth. He runs unchallenged at the Barnsley goal and calmly slots the finish past Gaga Slonina.
Eberechi Eze (Crystal Palace)
Eberechi Eze scores against his former side. He wins the ball inside his own half and has the pace and skill to run at the home defence.
He cuts on to his right foot and shoots at goal from 25 yards out but the strike takes a massive deflection off QPR's Steve Cook to wrongfoot Joe Walsh in goal.
Reiss Nelson (61 mins)
The man on loan from Arsenal gets Fulham level. Ryan Sessegnon pulls the ball back and Reiss Nelson sweeps it home.
Blackpool 0-1 Sheff Wed
The home side threaten as Pierce Charles is forced into some meaningful work in the Owls net from Dominic Thompson's shot.
Manchester United 3-0 Barnsley
A triple change for Barnsley at the break as they somehow look to claw their way back into this tie at Old Trafford.
Preston 1-0 Fulham
It is a crazy goalmouth scramble after Harrison Reed's shot smashes the bar. So, so close for Fulham. Just like that and the Premier League side spark into life.
Everton 1-1 Southampton
Shamoon Hafez
BBC Sport football news reporter at Goodison Park
That's twice now Jesper Lindstrom has ran clear and the Dane has been thwarted by Alex McCarthy on both occasions.
He really has to be doing better from openings like that.
Preston 1-0 Fulham
Championship side Preston are not settling as they push for a second, the ball is zipped across the box and it is frantically cleared from Fulham.
Sam Field (QPR, 53 mins)
An equaliser early in the second half for Championship QPR.
Dean Henderson in the Palace goal should do better from a corner, punching the ball up but not too far from goal.
The Eagles can't clear it, Sam Field takes a touch on the thigh to bring the ball down and then spins around and fires a left-footed finish into the net.
We are back under way in our five 19:45 BST games.
Brentford are 3-1 up against Leyton Orient, Everton and Southampton are level at 1-1, Preston lead Fulham 1-0, Sheffield Wednesday are leading 1-0 against Blackpool, and Queens Park Rangers trail 1-0 to Crystal Palace.
Blackpool 0-1 Sheff Wed
The away side go close to doubling their money.
Callum Paterson sees a header saved by Richard O'Donnell and then moments later the Scottish forward heads wide.
Manchester United 3-0 Barnsley
Paul Robinson
Former England goalkeeper on BBC Radio 5 Sports Extra
It inadvertently found Alejandro Garnacho, six yards out, one on one with the goalkeeper, pokes it home.
That's game over for Manchester United.
It all starts with Marcus Rashford, we've seen him do it so many times. He cuts inside, he takes on four Barnsley defenders.
And just as he tries to get the ball out of his feet, it ricochets off the last Barnsley defender, inadvertently puts Garnacho through.
Toe poke, bottom left hand corner of the corner. Nothing the goalkeeper can do.
Game, set and match.