Team news
Christian Norgaard and Kevin Schade are available for Brentford despite both being substituted against Crystal Palace as a precaution, while Ethan Pinnock is back in contention after recovering from injury.
Rico Henry missed out last weekend because of a hamstring issue that will sideline him for a number of weeks but Michael Kayode, who has joined on loan from Fiorentina, could make his debut.
Tottenham's Radu Dragusin injured his knee against Elfsborg in the Europa League and is ruled out, though fellow centre-back Micky van de Ven is back in contention after playing 45 minutes in Thursday's win.
Defenders Djed Spence and Sergio Reguilon are available again, having been ineligible in midweek.
Head coach Ange Postecoglou says most of Spurs' absentees could return in 10 days, with striker Dominic Solanke probably a week behind them, but the Australian is less sure when Cristian Romero will return.
Match facts
Head-to-head
Brentford have only won one of the seven Premier League meetings, with all three games at the Gtech Community Stadium drawn.
Tottenham are vying to complete their first league double against the Bees since joining the Football League in 1908.
Brentford
They are vying to win back-to-back league games for the first time since April.
Brentford are the Premier League's 29-goal leading scorers at home this season but have lost four of their past five home matches in all competitions.
Thomas Frank's side have conceded two top-flight goals from set-pieces this season (excluding penalties), a joint low with Manchester City.
Mikel Damsgaard has eight Premier League assists this season, one shy of an outright record for a Brentford player in a single campaign.
Bryan Mbeumo has scored 14 goals in his past 17 top-flight London derbies.
Tottenham Hotspur
Spurs have taken four points from the last 30 available.
They have been beaten in six of their last seven Premier League matches, losing each of the previous four.
Ange Postecoglou could become the first Spurs boss to lose five consecutive league games since Ossie Ardiles, who oversaw seven straight defeats in 1994.
The last time they lost five consecutive top-flight fixtures was during a run of six defeats in 2004, with Jacques Santini and Martin Jol each taking charge of three of those games.
Tottenham have lost 21 points from winning positions this season, more than any other side prior to the latest round of matches.
