Team news
Arsenal's Takehiro Tomiyasu will miss the rest of the season after having knee surgery.
The fit-again Ben White could make his first appearance since November, while Mikel Merino might come into the starting line-up after scoring twice as a makeshift striker at Leicester, but Bukayo Saka, Gabriel Martinelli, Gabriel Jesus and Kai Havertz are all unavailable.
West Ham will be without Lucas Paqueta for several weeks after he injured his ankle in training.
This match is likely to come too soon for Vladimir Coufal, who is nursing a hamstring issue.
Crysencio Summerville, Niclas Fullkrug and Michail Antonio all remain sidelined.
Match facts
Head-to-head
Arsenal have won the last two matches between the sides, scoring 11 goals in those games.
However, West Ham won on their most recent visit to the Emirates Stadium in December 2023.
West Ham have lost 37 Premier League games versus Arsenal, more than they have against any other club.
The Gunners won the reverse fixture in November 5-2, with all seven goals coming in the first half.
Arsenal
Arsenal are unbeaten in their last 15 Premier League matches (W10, D5), their longest such run since 2011.
The Gunners are also unbeaten in 15 home league games, and are the only Premier League team not to lose at home this season.
Mikel Arteta's side have scored 13 top-flight goals from crosses in 2024-25, more than any other side.
Nine of Arsenal's league goals this season have come from substitutes, including four in their last three games.
The Gunners have conceded just nine first-half goals in this season's Premier League, fewer than any other side.
West Ham
West Ham have lost five of their past seven Premier League matches (W1, D1) and earned just one point in their last four matches.
The Hammers have conceded a league-high 10 goals in the opening 10 minutes this season.
This will be their fifth London derby in their last six matches; they have lost three of the previous four.
The Hammers are yet to keep a clean sheet under Graham Potter, conceding 10 goals in all competitions since he took charge.
However, Potter has won three of his four games against Arsenal at the Emirates - only Pep Guardiola and Jurgen Klopp have won more at the stadium as a visiting manager.