Mark Harris is the first player from a newly promoted Championship club to score in his side's first four games of a season since Lyle Taylor for Charlton Athletic in 2019-20.
Oxford United maintained their 100% winning home league record as they beat Preston North End to make it two victories out of two.
Emil Riis put Preston ahead inside three minutes from close range - the visitors' first away goal in six league games.
But Mark Harris then levelled with a header as he netted for the fourth straight league game, before Tyler Goodrham cut in from the right to score a spectacular second on 53 minutes.
Then, just a minute after a second yellow card for Preston defender Liam Lindsay, Oxford sealed it against the 10 men when Greg Leigh found the net from close range - to confirm a first defeat for new North End boss Paul Heckingbottom.
Tyler Goodrham's only other previous goal this season was in the League Cup
This was the first league meeting between Oxford and Preston since the 1999-00 season in the third tier, when North End won both games under David Moyes.
But there was to be no repeat as the visitors lost away from home for the fifth successive match - their worst run in five years.
It looked hopeful for Heckingbottom's men when they took such an early lead but the U's levelled when Josh McEachran looped the ball into the box and Harris rose highest to head over stranded Preston keeper Freddie Woodman to keep up his hot scoring record.
Oxford, 2-0 opening-day winners at home to Norwich City, then went ahead for the first time with academy product Goodrham's first Championship goal before defender Leigh's first goal of the season secured all three points.
Who's next?
Both sides now have a fortnight to wait for their next game on Saturday, 14 September after the international break.
Oxford face a lunchtime kick-off at home to resurgent Stoke in one of the lunchtime kick-off games, while Preston are again on their travels, at Middlesbrough.
Oxford United boss Des Buckingham told BBC Radio Oxford:
“I was right behind Tyler Goodrham’s strike – and it was a wonderful finish. Seeing him cutting in on the right-hand side, it’s normally him doing that on the opposite side and curling it in with his right foot.
“That’s the reason we signed Tyler to a long-term contract at this club. He’s thriving at the moment in the Championship and long may that continue.
“It’s difficult when the opposition have a new manager in to plan what they might do, and they set up differently to what we thought they would. It took us a little while to get to grips with that. But we managed to get the message on and made some changes which balanced it up and got us back into the game.
“It’s a great start for us in this league. We were coming into the unknown, so to get six points from the first 12 – if you’d offered that to us before the season started with the amount of unknowns and the changes we’ve had in our squad we’d certainly have taken that.”
Preston North End manager Paul Heckingbottom told BBC Radio Lancashire:
“Coming in 1-1 at half-time it was hard to understand how we were level, but we had been wasteful at one end and the one thing we really got wrong we got punished for. We were upset about that.
“We started the second half well on the front foot and pressing to get the ball back again then their second goal is a killer again for us. It’s just a quick free-kick.
"We had bodies back and, from Oxford’s point of view, they’ll be saying that it’s an unbelievable finish from 25 yards but for us it’s very sloppy.
"All of a sudden we were 2-1 down and didn’t know what’s happened. So it was very frustrating for us in a game I felt we should have won.”
