Big chance for Southampton!

An acrobatic overhead kick is thumped away after great work by Kyle Walker-Peters.

Saints have a corner.

Fred is straight in the thick of the action.

Good defensive work by the substitute who gets pats on the back from his team-mates after winning a throw-in.

Six added minutes.

Fred is about to come for Christian Eriksen as smoke from a green flare where Manchester United's fans are seated drifts across St Mary's.

Romain Perraud and Lyanco have been sent on by Southampton. It's not quite panic stations but Saints need something to happen quickly.

Boos around St Mary's as Bruno Fernandes puts the ball out of play inside his own half as Scott McTominay lies on the ground injured.

Frustration from the home fans who feel play should have continued.

Half a chance for Armel Bella-Kotchap but he blazes over. Five minutes of normal time left.

Scott McTominay has picked up a yellow card. That's three in four games for the season. Impressive.

Ronaldo has shrugged off that knock from earlier and he's powering towards the Saints goal. He's inside the penalty box but great work by Mohammed Salisu who muscles the United player off the ball.

Now he's on!

United fans hold up a Brazil flag as Casemiro replaces Anthony Elanga.

Will the new £70m signing help United over the finishing line?

Image source, Getty Images

Hang on. Casemiro has retreated to his seat. He was getting ready to come on for Cristian Ronaldo but the Portuguese is limping on after that knock.

Meanwhile, Saints have sent on Sekou Mara.

Here he comes. United are getting Casemiro ready to come on.

Image source, BBC Sport

Manchester City manager Pep Guardiola makes two changes to the side that started the 3-3 draw against Newcastle. Nathan Ake is out through injury and Ilkay Gundogan drops to the bench as Ruben Dias and Riyad Mahrez start.

Man City XI: Ederson, Walker, Stones, Dias, Cancelo, De Bruyne, Rodri, Mahrez, Foden, Haaland, Silva.

Subs: Moreno, Gundogan, Alvarez, Martin, Palmer, Gomes, Lewis, Knight, Wilson-Esbran

Image source, BBC Sport

Crystal Palace make one change to the side that started their 3-1 win over Aston Villa last weekend with Nathaniel Clyne replacing Wilfried Zaha, who is not in the squad

Crystal Palace XI: Guaita, Ward, Andersen, Guehi, Mitchell, Clyne Doucoure, Schlupp, Ayew, Eze, Edouard.

Subs: Johnstone, Whitworth, Milivojevic, Olise, Mateta, Hughes, Ebiowei, Richards, Rodney.

Cristiano Ronaldo has taken a whack. He's on the ground and doesn't look comfortable. Is the substitute about to be substituted?

Image source, Getty Images

Image source, BBC Sport

Trevoh Chalobah comes in to replace the suspended Kalidou Koulibaly in the heart of Chelsea's defence, but that is the only change for the hosts following their 3-0 defeat against Leeds last weekend.

Mateo Kovacic is deemed fit enough to make the bench.

Chelsea XI: Mendy, James, Chalobah, Thiago Silva, Cucurella, Jorginho, Loftus-Cheek, Gallagher, Mount, Sterling, Havertz.

Image source, BBC Sport

Leicester make three changes from the Premier League loss to Southampton last Saturday and are without the influential James Maddison, who felt a twinge in training this week, but they do welcome Youri Tielemans back into the side.

Dennis Praet and Boubakary Soumare also come in, with Wilfred Ndidi and Ayoze Perez dropping to the bench.

Leicester XI: Ward, Justin, Evans, Amartey, Castagne, Soumare, Dewsbury-Hall, Tielemans, Barnes, Praet, Vardy.

Graham Potter makes one change to the Brighton side that defeated West Ham last weekend.

Ecuadorian full-back Pervis Estupinan is handed his first Premier League start, while Adam Lallana drops out of the matchday squad.

Brighton XI: Sanchez, Veltman, Dunk, Webster, March, Gross, Mac Allister, Caicedo, Estupinan, Trossard, Welbeck

Subs: Steele, Lamptey, Colwil, Mwepu, Alzate, Undav, Mitoma, Ferguson, Van Hecke

Image source, Getty Images

Jesse Marsch keeps faith with the Leeds XI that started last Sunday’s memorable victory over Chelsea at Elland Road.

Captain Liam Cooper is closing in on a return from an Achilles injury but is not among the substitutes at the Amex Stadium.

Leeds XI: Meslier, Kristensen, Koch, Llorente, Struijk, Adams, Roca, James, Aaronson, Harrison, Rodrigo

Subs: Klaesson, Forshaw, Summerville, Sinisterra, Gelhardt, Hjelde, Drameh, Greenwood, Klich

Image source, Getty Images

Francis Benali
Former Southampton defender on BBC Radio 5 live

Man Utd need something in midfield to stop the waves of Southampton attacks.

They are on the back foot and need some sort of change.

Brentford boss Thomas Frank makes just one change from last week's defeat at Fulham with Mathias Jorgensen coming into the side for Pontus Jansson, who does not make the squad.

Despite playing against Colchester in midweek, summer signing Mikkel Damsgaard must wait for his Premier League debut as the Denmark international is named on the bench.

Brentford XI: Raya, Hickey, Jorgensen, Mee, Henry, Dasilva, Norgaard, Jensen, Mbeumo, Toney, Wissa.

Subs: Ghoddos, Onyeka, Strakosha, Lewis-Potter, Damsgaard, Baptiste, Janelt, Sorensen, Roerslev.

Image source, BBC Sport

Tom Davies is not fit enough to start for Everton so Amadou Onana comes into midfield, while Dwight McNeil is recalled with Salomon Rondon dropping out.

There is no place in the Everton squad for new signing Neal Maupay and Anthony Gordon retains his place amid ongoing speculation over his future.

Everton XI: Pickford, Holgate, Coady, Tarkowski, Patterson, Onana, Iwobi, Mykolenko, McNeil, Gray, Gordon.

Subs: Begovic, Keane, Allan, Coleman, Davies, Vinagre, Rondon, Warrington, Mills.

Image source, BBC Sport

Che Adams continues to cause problems while substitute Stuart Armstrong is putting himself about but Saints are starting to run out of time.

Fifteen minute of normal time left.

Shamoon Hafez
BBC Sport at Anfield

Liverpool make just one change from the defeat by Manchester United at Old Trafford on Monday night.

Fabinho, who was surprisingly on the bench for the start of that game, is restored to the starting line-up in place of James Milner.

The Reds bench is lacking in any real depth and Jurgen Klopp has once again named two goalkeepers as substitutes.

Liverpool XI: Alisson, Alexander-Arnold, Gomez, Van Dijk, Robertson, Elliott, Henderson, Fabinho, Salah, Diaz, Firmino.

Bournemouth make three changes to the team that were beaten 3-0 by Arsenal last Saturday,

Ryan Christie, Lewis Cook and Jaidon Anthony come in with Lloyd Kelly, Ben Pearson and Philip Billing making way.

Bournemouth XI: Travers, A Smith, Mepham, Senesi, Zemura, Christie, Lerma, Tavernier, Cook, Anthony, Moore.

Only Mohamed Salah (54), Harry Kane (49) and Son Heung-Min (45) have more Premier League goals than Bruno Fernandes (37) since his debut in February 2020.