Newcastle will continue to monitor Sven Botman, who is making good progress in his recovery from a knee problem.

Alexander Isak is doubtful with a similar issue but Joelinton should return from a hamstring strain and Anthony Gordon is back after a ban.

Sandro Tonali,who is being investigated in relation to alleged illegal betting in Italy, is available.

Jefferson Lerma, Cheick Doucoure, Joel Ward and Naouirou Ahamada are fit for Crystal Palace after recent injuries.

Summer signing Matheus Franca has recovered from a back issue and is ready for his debut, but Eberechi Eze, Michael Olise, James Tomkins, Jeffrey Schlupp and Dean Henderson remain sidelined.

Newcastle United's Bruno Guimaraes and Joelinton sit down with Football Focus' Caroline de Moraes to talk about their Brazilian bromance, Champions League football and life in the Premier League.

Shamoon Hafez
BBC Sport at Anfield

A smattering of jeers as the Everton players come out to warm up at Anfield on a glorious October day.

It's the 243rd Merseyside derby but one Blues fans have had little cheer from in recent years.

Liverpool have lost just one of their last 28 meetings against their rivals, that coming behind closed doors in February 2021.

But after a sticky start, the Toffees have collected three wins in their last four games so confidence is high coming into one of their biggest games of the campaign.

Everton

Image source, Getty Images

Everton manager Sean Dyche speaking to TNT Sports: "I've only had one [derby] but it was a tremendous occasion. It's finding that automatic response for the team performance and that's what we're looking for.

"We felt the performances at the beginning of the season we're getting the results they deserved. We stuck to that task and you have got to keep performing.

"Dominic Calvert-Lewin getting fitter and sharper, Jack Harrison coming in off the back of an injury - we're getting that depth of fitness.

"I think you have to start right and defend well because they have a strong record. You need to make the game about yourselves as well and take it on. It's important we do that today.

"The feeling, the atmosphere, of course is all valid and relevant, but when you go out there it's all about the performance. [Victory] would reaffirm the good work we've been doing. I don't think the points tally is what it deserves."

Gonzalo Montiel is doubtful for Nottingham Forest after suffering a suspected calf injury playing for Argentina, while Serge Aurier's groin problem will be assessed.

Moussa Niakhate returns from a ban but Taiwo Awoniyi, Ola Aina, Danilo and Felipe remain unavailable.

Luton's Mads Andersen will be out for several months after injuring his hamstring against Tottenham.

Winger Andros Townsend could make his debut after joining as a free agent.

Defender Gabriel Osho has recovered from a knee issue and is in contention for his first appearance of the season, but this game comes too soon for Amari'i Bell.

Image source, Getty Images

Liverpool manager Jurgen Klopp was served an "uncomfortable" reminder of his excellent record in the Merseyside derby this week.

He has only lost one of 17 matches against the Toffees since joining the Reds in 2015, winning 10 times.

"It is uncomfortable when you tell me about my record," said Klopp.

"I couldn't be less interested in what happened in the past. We aren't thinking about this.

"We understand the importance of the game, the pressure. I can't remember enjoying the thought of a derby.

"There is a lot of intensity before a ball is kicked. It is a special game, a high-pressure game.

"All the players are used to the kind of game. We shouldn't make it too big for the new players; they are ready for it."

Liverpool's only defeat in the past 28 meetings in all competitions was by 2-0 in the top flight at Anfield in February 2021 (W14, D13).

That victory was Everton's third at Anfield in the Premier League - and first for 22 years - after a 1-0 success in 1999 and a 2-1 win in 1995.

The Toffees have failed to score in 26 of their 62 Premier League games with Liverpool - it's their worst record against any opponent.

The Merseyside derby has produced 22 red cards in the Premier League era, five more than any other fixture.

Ben Osborn and possibly George Baldock are in contention to return to Sheffield United's squad.

Chris Basham is a long-term absentee after breaking his ankle against Fulham, joining a lengthy injury list.

Casemiro has been ruled out for Manchester United after sustaining a minor injury on international duty.

However, defenders Raphael Varane and Sergio Reguilon are fit again and Sofyan Amrabat is available despite missing both of Morocco's games.

BBC Sport takes a look back at Jack Wilshere's 2013 Goal of the Season for Arsenal against Norwich City on its 10th anniversary.

Image source, Getty Images

How well do you know the history of the Merseyside derby and what happened in recent matches between the rivals?

Take our quiz here.

Bournemouth have been boosted by the return of Phillip Billing, Lloyd Kelly and Chris Mepham.

Summer signing Alex Scott has also returned to training but is lacking match fitness, while Tyler Adams faces another lengthy spell on the sidelines after a second hamstring surgery.

Wolves are without suspended pair Mario Lemina and Nelson Semedo.

Hugo Bueno is a doubt with a hamstring strain but Jean-Ricner Bellegarde is back after serving a three-match ban.

Image source, Getty Images

Jack Harrison scored and assisted a goal on his first Premier League start for Everton against Bournemouth last time out.

His first ever Premier League goal came against Liverpool at Anfield (September 2020).

He also played for Leeds in their 2-1 win at the Reds in October last season - the last time Liverpool lost at home in the league.

Image source, Getty Images

So no place in the starting XI for Harvey Elliott, as Ryan Gravenberch gets the nod.

Elliott said this week he is fully aware of the challenges he faces becoming a regular at Liverpool with "healthy competition" for places.

The 20-year-old has played 164 minutes in the Premier League this season with competition in Jurgen Klopp's midfield.

"It's healthy competition. Not everyone is guaranteed to play, and when you get your chance you have to make sure you take it. The quality is there, it's about applying it on the pitch," he said.

"I feel I can do a job wherever I'm put. The most important thing is putting that red shirt on and playing. I'm working as hard as I can to get into the team.

"It's down to me to make sure I apply myself and not only show the boss but show the world I'm good enough to play wherever I'm put."

Liverpool make four changes to the side that drew 2-2 with Brighton before the international break.

Kostas Tsimikas replaces Andy Robertson who picked up that shoulder injury on Scotland duty.

Diogo Jota returns from a one-match ban, coming in for Darwin Nunez. Ibrahima Konate replaces Joel Matip at the back, and Ryan Gravenberch, making his first Premier League start, gets the nod over Harvey Elliott.

Liverpool XI: Alisson; Alexander-Arnold, Konate, Van Dijk, Tsimikas; Szoboszlai, Mac Allister, Gravenberch; Salah, Jota, Diaz.

Subs: Kelleher, Gomez, Endo, Nunez, Elliott, Matip, Scanlon, McConnell, Quansah.

No changes for Sean Dyche's Everton from the side that cruised past Bournemouth 3-0 last time out.

Idrissa Gueye returns to the bench after sitting out the past few weeks with a heel problem.

Everton XI: Pickford; Young, Tarkowski, Brathwaite, Mykolenko; Harrison, Garner, Onana, McNeil; Doucoure; Calvert-Lewin.

Subs: Virginia, Patterson, Keane, Danjuma, Beto, Godfrey, Gueye, Chermiti, Dobbin.

Michael Emons
BBC Sport reporter

Image source, Getty Images

It's the 243rd Merseyside derby today.

Jurgen Klopp's Reds start fourth in the Premier League, while Sean Dyche's Toffees are 16th.

Liverpool have had the better of the recent meetings and have only lost one of the past 25 league encounters.

BBC Sport has taken a look back at some of the best moments from previous derbies between the two famous clubs...

Take a look here.

BBC Radio 5 Live

We've got Premier League chat from 12:00 BST all the way through to 19:30 BST on BBC Radio 5 Live today.

Mark Chapman will present build-up to the Merseyside derby to kick things off, followed by live commentary of Manchester City v Brighton.

We've also got live commentary of Chelsea v Arsenal from 17:30 BST.

Image source, Getty Images

Liverpool left-back Andy Robertson is to have an operation on the shoulder he injured while playing for Scotland.

He was hurt in a challenge with Spain keeper Unai Simon during their Euro 2024 qualifying defeat.

"That means he's out for a while. I don't know exactly how long," said Jurgen Klopp.

"You only see the real extent of injury when you have a look into it, like properly open [up the shoulder] and fix it - but my experience tells me around three months.

"In my experience you can train pretty quickly again but not football-specific because you have to be careful of challenges and all these kind of things so he will be out for a while."

Malo Gusto returns for Chelsea after a three-match ban, while Reece James, who has been out for two months, has resumed training and will be assessed.

Axel Disasi and Nicolas Jackson are doubts after withdrawing from international duty through injury.

Armando Broja, Trevoh Chalobah, Carney Chukwuemeka, Ben Chilwell, Christopher Nkunku, Wesley Fofana and Romeo Lavia are all ruled out.

Arsenal will continue to monitor Bukayo Saka and Leandro Trossard.

They are both nursing hamstring issues, while William Saliba - who is managing a toe problem - is also an injury concern but Jurrien Timber is the only confirmed absentee.

The Redmen TV's Chloe Bloxam and The Blue Room Podcast's Les Roberts joined The Football News Show to share their nerves ahead of the first Merseyside derby of the Premier League season.

We've got a stacked schedule today. Here's what's coming up (all kick-off times 15:00 BST unless stated):

Liverpool v Everton (12:30 BST)

Bournemouth v Wolves

Brentford v Burnley

Manchester City v Brighton

Newcastle United v Crystal Palace

Nottingham Forest v Luton Town

Chelsea v Arsenal (17:30 BST)

Sheffield United v Manchester United (20:00 BST)