Stuart Lancaster makes further changes to his line-up. Tom Wood makes way for Tom Johnson while Danny Care is replaced by Lee Dickson at scrum-half.

Image source, Getty Images

England's previous best in Rome was a 59-12 victory back in 2000. They could be close to that margin by the end of this match but it will have to be a turbo-charged final 15 minutes from Stuart Lancaster's men if they are to beat their record win against the Azzurri, which was a 80-23 victory in Twickenham.

Andy Robinson
Ex-England and Scotland coach in Rome on BBC One

"The Italian defence is in disarray. That attack came from a really good structured line-out. We're into the final quarter and it's vital England keep their discipline and structure."

Paul Grayson
Former England fly-half on BBC Radio 5 live

"Bang on the hour mark Italy look broken. No resistance through the heart of their defence there. Mako Vunipola shrugged off a half-hearted tackle to go through. It could just be on you know. Three converted tries, England are well capable of doing that. England are on top of everything, even the scrum has righted itself."

A perfect line-out. Manu Tuilagi has possession, he recycles. England's forwards punch holes in Italy's defence, Billy Twelvetrees skips by Paul Derbyshire and pops the ball up nicely for Mako Vunipola, who has to do little other than stroll over. The faultless Owen Farrell converts. Obviously.

Italy lose possession, Owen Farrell boots it downfield but back come Italy once more. Luke McLean opts for the diagonal kick but it's out on the full and it's a line-out to England on the halfway line.

Andy Robinson
Ex-England and Scotland coach in Rome on BBC One

"England have shown good disciplined defence. They haven't looked like being broken. It's right that England are making changes but it's important it doesn't disrupt the team."

So Tuilagi comes on for Burrell. Much was made of when he would be used, but should Burrell have made way?

Gully Burrows:, external Why bring Burrell off? He is so much more of a try threat than Twelvetrees.

Chris Fletcher:, external Why take off Burrell when he is playing well and has been great all tournament just to give Tuilagi a run out?

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Luke McLean attempts to puncture England's defence but the visitors hold firm, with Mike Brown pushing the full-back into touch. Italy, though, attempting to build momentum.

Enter the behemoth Manu Tuilagi and the impressive Luther Burrell makes way for the young Leicester centre. Dylan Hartley is also replaced by Tom Youngs.

Paul Grayson
Former England fly-half on BBC Radio 5 live

"Italy only have themselves to blame. They had England under all sorts of pressure in the scrum. The decision to take off the two props makes no sense. That was a nicely executed try by England."

Sir Clive Woodward
Former England coach in Rome on BBC One

"I'm very sorry and very surprised that Luther Burrell has come off. Tuilagi is a class player but I would have left it a little longer."

Lewis Moody
Former England captain in Rome on BBC One

"There's been a lot of talk about England's replacements and Manu Tuilagi. But the most important one for me is George Ford. If we're going to see England improve then we need to see some strength in depth. Get Ford on the pitch and give him some game time."

The pressure is constant and eventually Italy's defence crumbles, with Mike Brown setting Jack Nowell free for his first England try. A simple conversion for Owen Farrell.

Image source, AP

It's a messy old business and iffy discipline means Marco Bortolami is sin binned for being offside when stopping Luther Burrell's tryscoring attempts.

Danny Care takes a quick free-kick, letting Luther Burrell loose. The giant centre attempts to touchdown but is prevented from doing so by Leonardo Sarto.

England's fans are calling for their chariots to swing low but the home fans respond by drowning out the visitors with a tune of their own. Ben Morgan drives from the base of the scrum. Danny Care is sniping on the fringes...

For all their worries and woes, Italy can always rely on their scrum. The men in Italy's boiler room force England to, once again, concede a penalty, but the Azzurri are unable to keep possession long enough to pressurise England.

England find themselves in Italy's 22 and Jack Nowell steps in from the wing. Adventure from the visitors as Owen Farrell attempts to release the youngster on his inside, but Italy's defence hold firm.

Andy Robinson
Ex-England and Scotland coach in Rome on BBC One

"That was an opportunity for Italy - not a clear opportunity - after a missed tackle by Luther Burrell. Campagnaro lost his boot in the process which slowed him down a bit."