Harlequins have another good platform with an attacking lineout deep in Irish territory.

Well that was tight.

A forward pass by replacement George Merrick ends a very promising attacking situation for Harlequins after a great turnover by Chris Robshaw

Are London Irish tiring or feeling the nerves? Or both? The Premiership newcomers have been superb all afternoon but pressure can do funny things.

Quins have been far from their best, but two converted tries and they can win this. Still more than ten to go.

Irish have scored three fabulous tries but their defence has been just as impressive.

Quins have not looked particularly threatening after the break and haven't scored a point yet. But they have a penalty and kick to the corner.

It's a bit static from Quins now. But they welcome back fly-half Demetri Catrakilis and are at full strength.

Can they mount a comeback in the final quarter?

Chris Jones
BBC 5 live rugby union commentator

What a try from Irish! It's their third and each one of them has been absolute beauties.

They've not just tried to settle on their lead, they've kept playing and tried to take advantage of their extra man.

London Irish will be chuffed with how things are going so far. Can they hold on - or maybe extend that lead in the next few minutes while they have the extra man?

London Irish make Quins pay for the infringement, the reliable boot of Tommy Bell doing the damage.

There's been a whole host of changes, Demetri Catrakilis is the man to come on for Marcus Smith.

But within less than a minute he's got a yellow card for failing to roll away and is off. Seems harsh.

Well I suppose that it an impact. A penalty is conceded that could see Irish extend their lead.

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Teenage fly-half Marcus Smith has done well for Harlequins but it looks like his day's work is over. He reluctantly comes off.

It was a big hit he took there to say the least.

A great take by Mike Brown sets up a Quins attack and the passage of play leads to Marcus Smith taking a hell of a whack Tikoirotuma.

He's sat on the Twickenham turf receiving treatment and play is stopped. Welcome to the Premiership.

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There's a bit of a lull on the pitch and the crowd have quietened down too.

Playing 80 minutes is tough. And It's a long day if you do back-to-back games as a fan.

Topsy Ojo is off for a head injury assessment following the winger's big collision with Harlequins full-back Mike Brown a couple of minutes ago.

Aseli Tikoirotuma is on.

A bad time for a drop. Harlequins' Joe Marler is the guilty man. No excuses for that fumble by the England man.

He looks bemused and embarrassed in equal measure,

And London Irish can have a slight breather

Resolute work by the London Irish defence in the early stages of the second half.

A typical Danny Care break leads to a penalty though, and Marcus Smith find touch deep in Irish territory.

Off we go again for the final 40 minutes of action at Twickenham this afternoon. Quins' Marcus Smith kicks us off.

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Tigers fans will of course be glad to see Manu Tuilagi fit and raring to go. But so will be England boss Eddie Jones.

The man mountain of a centre has had an horrendous time with injuries in the past couple of years, but starts against Bath tomorrow.

Club and country colleague Ben Youngs expects Tuilagi to thrive this season.

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The weekend's rugby action is far from over. Leicester host Bath at Welford Road on Sunday in a match that has all the ingredients to be a classic.

Summer signings Jonny May and George Ford both start for Tigers, who also welcome back England centre Manu Tuilagi.

Bath have a trio of British and Irish Lions in their starting line-up.

There's more detail in our match preview.