Sale do get the next score as Joe Marler is penalised for Quins and AJ MacGinty punishes him from the tee.

Exeter and Leicester are heading back into the changing rooms for a few final words.

Today's referee at Sandy Park is Wayne Barnes and the TMO is David Rose.

We hope that you're ready for this because it should be a belter to finish this busy first Saturday of the new Premiership season.

Alongside their familiar names, Matt O'Connor has handed debuts to five of his new arrivals.

Will Spencer and David Denton start in the forward pack, while props David Feao and Gaston Cortes, and sparky centre Kyle Eastmond are amongst the replacements.

Also, keep an eye out for Jordan Olowofela coming off the bench. The 20-year-old winger was named in Eddie Jones' recent pre-season training squad and had an outstanding tournament at the World Rugby U20 Championship in June.

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Replacements: Polota-Nau, Feao, Cortes, Wells, Williams, Harrison, Eastmond, Olowofela.

Time to look at the home side's line-up...

Rob Baxter's outfit will start their new campaign under the stewardship of club captain Jack Yeandle.

The team are missing new signing Alex Cuthbert, England's Jack Nowell and Mitch Lees. The trio are all recovering from surgeries in the summer but a potent XV and bench remains.

Internationals Alec Hepburn, Tomas Francis, Don Armand, Sam Simmonds and Matt Kvesic all take places in the Chiefs' pack while Nic White and Gareth Steenson form an experienced half-back axis.

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Replacements: Cowan-Dickie, Holmes, Williams, Salmon, Lonsdale, Townsend, Simmonds, Slade.

Another penalty for Harlequins and another three points for Marcus Smith.

You sense Sale need the next score.

Before we dive into the team line-ups, and the players that will be running out for these fans' sides, let's look at a few and records.

Interestingly, Exeter's only victory in Round 1 in the last five seasons was 52-0 at London Welsh in 2014, however this is the first time that The Chiefs have started the season with a home fixture at Sandy Park since 2012.

Focusing on today's visitors - Leicester Tigers opening weekend defeat at home to Bath twelve months ago ended a run of five successive Round 1 victories.

The Chiefs have won four of their last six contests with Tigers in Premiership Rugby, whilst Leicester’s most recent triumph at Sandy Park was in 2014.

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There is an adage that says it is easier to climb to the top of the tree than it is to actually remain there.

It is one that Exeter Chiefs might acknowledge after last season's heartbreaking Premiership final defeat by Saracens.

The former champions might have lost their grip on the crown. but as Jack Yeandle says, they won't allow their 2016-17 success to be a flash in the pan.

A perfect start to the second half for Harlequins as Marcus Smith slots over a penalty from 40m out.

Suddenly Quins have a seven-point lead.

Repeated high-tackles have seen Alafoti Fa'osiliva sent to the sin bin.

Will Wasps capitalise with a man advantage? They've 10 minutes to make it count...

"It put so many things in perspective and really makes you appreciate how special times are," said Leicester and England scrum-half told Ben Youngs.

"Tiff's gone through the mill but Tom's been there every step of the way. When she had long periods in hospital, he's been a full-time rugby player, a full-time dad and a husband. He's a new man - I just hope this is a bad memory, and we can all enjoy what's hopefully going to be an amazing future.

"Rugby has been a distraction. You can kind of escape it for 80 minutes, but then the game's finished and it's back to reality. We're blessed with having such an amazing support from team-mates and coaching staff at Leicester. They've been unbelievable in terms of helping the family."

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One of the most welcome stories to break in the world of rugby union in the past few months was the news that Tiffany Youngs, wife of Leicester hooker Tom, was in remission from cancer.

She had previously been given the diagnosis that her illness was terminal.

Youngs' brother and team-mate Ben spoke to BBC Radio Leicester earlier this week about a difficult 12 months for their family, and the positive outcome that followed in May...

Just to mark your cards, we're going to keep on bringing you all of the key moments from the Twickenham Stoop and Sixways.

Alongside that, we'll be turning the spotlight on the final match of the day between Exeter and Leicester at Sandy Park.

Don't forget to continue sharing your predictions about the 2018-19 Premiership season using #bbcrugby.

Gloucester fly-half Danny Cipriani told BT Sport:

"From top to bottom this is a great organisation and the way that they have made myself and Banners [Matt Banahan] and the new players feel at home has been exceptional.

"It's a credit to the team, and a credit to the boys, how we bought into what we're trying to do this season. Just very proud to be out here and to be part of this club."

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A breathless half at The Stoop with five tries but a worrying injury to Sale and England flanker Tom Curry.

Former England defence coach Paul Gustard has seen his side score three times but will be less than pleased with the two tries they conceded.

A fascinating second half is on the cards.

Gloucester mark their 5000th competitive match in the right fashion.

One of the moments of the match, Danny Cipriani's sublime left to right missed pass, will be greatly spoken about but the man himself was quick to highlight the performance of the pack in his post-match interview.

Gloucester navigated their way through two sin-bin periods while for Northampton discipline and individual errors cost them.

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Heinrich Brüssow was the man who picked the ball up out of the ruck and his break led to Ehren Painter crossing but Brüssow was deemed to be in an offside position. No try and no losing bonus-point for Northampton.