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Back in 2001, these two teams crossed the line more often that Donald Trump's Twitter account.

England ran out 80-23 in a victory that featured 12 tries.

England's try-scorers that day were Balshaw (2), Cohen, Dallaglio, Greenwood, Healey (2), Regan, Wilkinson, Worsley.

Iain Balshaw was a baller wasn't he? More gas than a Russian oligarch.

Sara Orchard
BBC Sport rugby union commentator at Twickenham

Exeter's Luke Cowan-Dickie is rewarded with a first Six Nations start after strong performances that helped lead his club to domestic and European honours last season, but could England's changes have gone deeper?

Dropping the under-used Ollie Lawrence and not testing out either Wasps wing Paolo Odogwu or Bristol scrum-half Harry Randall could be a missed opportunity against the tournament's weakest side.

Italy have turned to the experience of Carlo Canna and Andrea Lovotti, with both men closing in on 50 caps.

However, England will be desperate for a reaction to their result against Scotland and no Italian is expected to work the magic required to change the result from the loss against France.

Sara will be calling the action on the BBC highlights that will be available about 30 minutes after the final whistle. You can also listen in live on BBC Radio 5 Live Sports Extra this afternoon. Tune in via the top of this page, the BBC Sounds app, your digital radio etc.

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Back in June 2002, another youthful Italian team came a cropper against one of the game's superpowers.

A New Zealand side including the likes of Andrew Mehrtens, Doug Howlett, Christian Cullen and Jonah Lomu ran out 64-10 winners in Hamilton.

But two of the visitors making their debuts that day - an 18-year-old Sergio Parisse and a 20-year-old Martin Castrogiovanni - went on to become cornerstones of the most successful Italy team ever.

Does this current Italy team need similar patience and time to develop? BBC Sport spoke to Castrogiovanni and Andrea Masi - another of the nation's golden generation - to find out...

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Italy head coach Franco Smith has injected more experience into his side in the wake of last weekend's 50-10 defeat against France bringing in centre Carlo Canna and prop Andrea Lovotti for the trip to Twickenham.

Canna - the most capped player in the starting XV on 48 - replaces the injured Marco Zanon and pushes last weekend's debutant Juan Ignacio Brex to outside centre.

Smith does however continue with the youthful half-back pairing of fly-half Paolo Garbisi, 20, and Welsh-born scrum-half Stephen Varney, 19.

Despite Lovotti and Canna's inclusion, Italy are still markedly light on experience with just 224 caps in their starting XV compared to England's 810.

Italy:15-Trulla; 14-Sperandio, 13-Brex, 12-Canna, 11-Ioane; 10-Garbisi, 9-Varney; 1-Lovotti, 2-Bigi (c), 3-Riccioni, 4-Lazzaroni, 5-Sisi, 6-Negri, 7-Meyer, 8-Lamaro.

Replacements:16-Lucchesi, 17-Fischetti, 18-Zilocchi, 19-Cannone, 20-Ruzza, 21-Palazanni, 22-Allan, 23-Mori.

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Leicester's George Ford returns at 10 to resume his play-making axis with Owen Farrell, who shifts to 12. Ollie Lawrence is the man to miss out as the 21-year-old bombs out of the matchday squad entirely.

Exeter hooker Luke Cowan-Dickie gets a first Six Nations start in place of Jamie George, while Saracens prop Mako Vunipola and Bristol's Kyle Sinckler return in the front row from injury and suspension respectively. Courtney Lawes gets Mark Wilson's back row slot.

Ben Earl and Jack Willis are both on an eight-man bench containing six forwards.

England:15-Daly; 14-Watson, 13-Slade, 12-Farrell (c), 11-May; 10-Ford, 9-Youngs; 1-M. Vunipola, 2-Cowan-Dickie, 3-Sinckler, 4-Itoje, 5-Hill, 6-Lawes, 7-Curry, 8-B. Vunipola.

Replacements:16-George, 17-Genge, 18-Stuart, 19-Ewels, 20-Earl, 21-Willis, 22-Robson, 23-Malins.

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The teams have turned up at Twickenham, as you would hope.

Differing styles of facemask, with Ellis Genge going for the small is beautiful look and Luca Bigi looking like Bane if he came from Verona.

On with the cast list...

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Becky Grey
BBC Sport at Twickenham

Four jumpers and two pairs of gloves aren't helping to keep the Twickenham chill out.

If I go quiet about 20 minutes in, you'll find me frozen solid in the West Stand.

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Frankly if England's forwards don't play a bit more expansively this weekend, then they will have to hand out foil blankets to the wings.

It is the sort of weather to set a brass monkey's knees knocking. Flat zero degrees come kick-off according to BBC Weather.

A rival service has a catchy trademarked Realfeel number that puts us down to -2 with wind chill etc. Which is the real quiz.

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“We’ve got to have a bit of fear going into any of these games that we can’t take these for granted.”

So said Courtney Lawes this week.

But how much will England's knees tremble and nerves rattle at some of the numbers generated by meetings with Italy in the past?

England have won all 21 of their Six Nations meetings with the Azzurri, racking up an average of 40.4 points. Italy are trying to break a losing streak of 28 straight matches in the tournament.

It is definitely Saturday 13th rather than Friday 13th.