Kate Williams try gives Wales early lead but Italy reply through Sofia Stefan's try and the boot of Michela Sillari, only for Gwenllian Pyrs to score on stroke of half-time to retake lead for Wales.
Francesca Granzotto twice, Silvia Turani, Vittoria Minuzzi and Aura Muzzo cross as Italy take control after break; Wales' misery compounded by Natalia John's late sin bin for head-on-head contact.
Game moved back a day from Saturday due to the funeral of Pope Francis.
Live Reporting
Matt Lloyd
Postpublished at 73 mins
73 mins
Italy 32-12 Wales
Lleucu George uses that big boot of hers to get Wales upfield with a 50-22.
Right then... can Wales build something from here?
Converted try: Italy 20-12 Walespublished at 53 mins
53 mins
Francesca Granzotto try, Michela Sillari con
It went to a review but it's given.
The replacement wing finishes a wonderful flowing attack.
The forwards carried hard and then it's just the speed of ball across the line that beats the Welsh defence despite a solid cover tackle by Wales' Hannah Bluck.
And Sillari converts from the touchline. That was a belting seven points all round.
Italy's off-loading game is wonderful to watch but we've just seen one player palm away a pass as though playing volleyball and then Sillari puts the ball between her legs.